Table of Content

01 April 2023, Volume 11 Issue 2

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Influence of tumor cell positive in peripheral blood circulation on perioperative coagulation function in operable breast cancer patients

ZHANG Chenglei

2023, 11(2):  2. 

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Objective To analyze the influence of positive circulating tumor cell (CTC) in peripheral blood of operable breast cancer patients on coagulation function in perioperative period. Method 80 cases of breast cancer patients who underwent surgical treatment in Zhanjiang Central People's Hospital from July 2019 to March 2020 were selected for the study. According to the level of tumor cells in their peripheral blood circulation, they were divided into positive group (preoperative CTC positive) and negative group (preoperative CTC negative). Before operation, on the 1st, 3rd, 7th and 14th day after operation, the patients were tested by routine coagulation function indexes and thromboelastogram. The results of coagulation function and thrombelastography were compared between the two groups. Result Among the 80 patients, 12 were positive for CTC, with a positive detection rate

of 15.00%. There were no significant difference in FIB and DD levels between positive group and negative group at different time before and after operation (P ＞ 0.05). The prothrombin time, activated partial thrombin time, thromboelastogram reaction time, and coagulation time in the positive group were significantly lower than those in the negative group, and the platelet count, thromboelastogram maximum amplitude, and Angle angle were significantly higher than those in the negative group, with significant differences (P ＜ 0.05). Conclusion Patients with operable breast cancer who have positive circulating tumor cells before operation have abnormal coagulation function during the perioperative period and have potential risk of deep vein thromboembolism.

The choice and efficacy of treatment for elderly patients with choledocholithiasis combined with cholecystolithiasis

LIU Dongdong, YU Anxing, LI Bin

2023, 11(2):  7. 

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Objective To explore the choice and efficacy of treatment for elderly patients with choledocholithiasis combined with cholecystolithiasis. Method The elderly patients with cholecystolithiasis and choledocholithiasis diagnosed in Pingdu People's Hospital hospital from February 2017 to November 2019 were selected and randomly divided into the observation group (n=34) and the control group (n=32). The observation group was treated with step-by-step endoscopic sphincteropapillotomy(EST) combined with laparoscopic cholecystectomy (LC), and the control group was treated with LC combined with laparoscopic common bile duct exploration T-tube choledochotomy (LCBDE). The total operation time, indwelling time of drainage tube after operation, intraoperative bleeding, postoperative hospital stay, conversion from laparoscopy to laparotomy, stone removal rate, and postoperative complications (including fever, bile leakage, pancreatitis) were compared between the two groups. Result The total operation time, drainage tube retention time, and postoperative hospitalization time of patients in the observation group were shorter than those in the control group, with less intraoperative bleeding and lower conversion rate to laparotomy in the observation group (P ＜ 0.05). There was no significant difference between the two groups in stone removal rate and postoperative complication rate (P ＞ 0.05). Conclusion Both EST+LC and LC+LCBDE can effectively treat the elderly patients with cholecystolithiasis and choledocholithiasis, but in county hospitals with both technology and equipment, EST+LC is more beneficial for elderly patients with choledocholithiasis and choledocholithiasis.

Analysis of the efficacy of linaclotide in patients with functional constipation

MA Lin, CHEN Yongqiang, WANG Cai

2023, 11(2):  11. 

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Objective To explore the efficacy of linaclotide in treating colonic obstruction in patients with functional constipation. Method From June 2019 to June 2022, 80 patients with colonic obstruction caused by functional constipation who were diagnosed and treated by the Eighth People's Hospital of Qingdao City were randomly divided into a control group and an observation group, with 40 patients in each group. The patients in the control group received routine treatment, including general treatment, anal exhaust, and enema. The observation group was treated with linaclotide on the basis of the control group. Compare the efficacy, frequency of defecation, stool characteristics, abdominal distension, sense of difficulty in defecation, abdominal pain scores, constipation

specific quality of life scores, and the occurrence of adverse reactions between the two groups. Result The efficacy of the observation group was 95.00%, significantly higher than that of the control group (77.50%), with a significant difference (P ＜ 0.05). Before treatment, there was no significant difference between the two groups in stool characteristics, defecation frequency, abdominal distension, sense of difficulty in defecation, abdominal pain scores, and constipation specific quality of life scores (P ＞ 0.05); After treatment, the stool characteristics, defecation frequency, and abdominal distension, defecation exertion, abdominal pain scores, and constipation specific quality of life scores of the two groups of patients were significantly increased, and the range of change in the observation group was significantly higher than that in the control group (P ＜ 0.05). During the treatment period, the incidence of adverse reactions was 12.50% in the observation group and 10.00% in the control group, with no significant

difference (P ＞ 0.05). The recurrence rate in the observation group was 2.50%, significantly lower than that in the control group (15.00%), with a significant difference (P ＜ 0.05). Conclusion Linaclotide is effective in improving the clinical outcomes of patients with functional constipation and colonic obstruction.

Research progress on the mechanism of flora imbalance and pancreatic cancer

ZHANG Yuting, ZHANG Yanjun, GONG Zengfeng, PENG Yanni, WEI Jing, WANG Fujuan, YAN Hongfang, MIAO Long

2023, 11(2):  16. 

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Pancreatic cancer is one of the malignant tumors with the worst prognosis, with a five-year survival rate of less than 10%, and surgical resection is currently the main treatment method. However, due to the lack of typical clinical manifestations in the early stage of pancreatic cancer, it is usually diagnosed in the late stage of the disease, and most patients lose the opportunity of surgical treatment, while other treatments bring poor efficacy, therefore, early diagnosis of pancreatic cancer is more and more important in clinical practice, and early diagnosis will greatly improve the prognosis of pancreatic cancer patients. More and more studies have shown that the occurrence of pancreatic cancer is related to the alteration of microflora in human body. In this paper, we summarize the current research on human microflora and pancreatic cancer development, and explore the changes of human

microflora in the development of pancreatic cancer and the possible mechanisms of action. Human microbes are expected to be markers for early diagnosis of pancreatic cancer, which may open a new pathway for biomarkers and targeted therapy.

Research status of targeted combination with other therapies for primary liver cancer

HUANG Dong, CHEN Bin

2023, 11(2):  20. 

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Primary liver cancer lacks obvious typical clinical manifestations in the early stage, once obvious symptoms or signs appear, the disease has mostly entered the middle and advanced stages, most of them have lost the opportunity for surgery when they are diagnosed, and some operable patients have early recurrence after surgery and have a poor prognosis. Therefore, non-surgical treatments such as targeted therapy, immunotherapy, radiofrequency ablation, vascular interventional therapy, and traditional Chinese medicine therapy have significant effects on the treatment of liver cancer in the middle and advanced stages, especially targeted therapy for liver cancer is a hot topic now. In this paper, this article reviews the current research progress of targeted therapy for liver cancer and the research status of combination with other treatments.

Advances in finding benefits for colorectal cancer patients with ostomy

JI Yanyan, WANG Kaixuan, LI Chang, YANG Lu, ZHANG Dianliang, LIU Zhimei

2023, 11(2):  24. 

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With the increasing incidence of colorectal cancer, the number of enterostomy patients is increasing. The psychological problems of enterostomy patients become increasingly prominent. As an important part of positive psychology, benefit discovery can change patients' health behaviors and improve their mental state and quality of life to some extent. In this paper, the research progress of benefit finding in enterostomy patients was summarized from the concept of benefit finding, measurement tools, influencing factors and intervention strategies of benefit finding in enterostomy patients, to provide reference for domestic research on benefit finding in enterostomy patients.

Clinical effect of laparoscopic hernioplasty for inguinal hernia

GE Xingpeng

2023, 11(2):  29. 

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Objective To explore the application value of laparoscopic hernioplasty in the treatment of inguinal hernia, observe the prognosis of patients, and evaluate the treatment effect. Method 80 patients with inguinal hernia admitted to the First People's Hospital of Guannan County, Lianyungang City from May 2021 to May 2022 were randomly divided into two groups by digital table method. The control group (n=40) adopted open tension-free inguinal hernia repair. The study group (n=40) adopted laparoscopic hernia repair. The operation and postoperative related indicators, quality of life scores, pain and sleep scores, and complications of the two groups were compared. Result The operation time of the patients in the study group was longer than that in the control group, the time of getting out of bed and hospitalization were shorter after operation, and the amount of intraoperative bleeding

was less than that in the control group, with significant difference (P ＜ 0.05); The pain score, sleep quality score and complication rate in the study group were significantly lower than those in the control group (P ＜ 0.05). Conclusion Laparoscopic hernioplasty for inguinal hernia can improve the clinical symptoms, relieve postoperative pain, improve the quality of life and clinical safety.

Clinical observation of high ligation of inguinal hernia sac with water injection hernia needle under three-dimensional laparoscopy in children with indirect inguinal hernia

LI Dongru

2023, 11(2):  33. 

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Objective To investigate the effect of high ligation of hernia sac for oblique inguinal hernia and three-dimensional laparoscopic water injection hernia needle. Method Sixty children with indirect inguinal hernia admitted to the People's Hospital of Lianshui County, Huai'an City from January 2018 to April 2022 were randomly divided into a control group (30 cases treated with conventional laparoscopy) and an observation group (30 cases treated with 3D laparoscopy) using a digital table method. The surgical related indicators, C reactive protein (CRP), interleukin(IL)-10, and other inflammatory indicators before and after treatment in the two groups were compared, The incidence of complications in the two groups of patients was statistically analyzed and compared. Result The intraoperative diagnostic time and surgical time in the observation group were shorter than those in the control group (P ＜ 0.05). There was no significant difference between the two groups in terms of hospitalization

expenses and time, as well as in the levels of CRP and IL-10 after surgery (P ＞ 0.05),however, the levels of CRP and IL-10 in both groups of patients after surgery were significantly improved compared to those before surgery (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion High ligation with a hernia needle assisted by three-dimensional laparoscopy in the treatment of children with indirect inguinal hernia is simple and minimally invasive, and does not increase hospital stay.

Effect of predictive nursing on postoperative nausea and vomiting in patients undergoing thyroid surgery

JIANG Qifang, YAN Rong

2023, 11(2):  46. 

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Objective To explore the preventive effect of predictive nursing on postoperative nausea and vomiting in patients undergoing thyroid surgery. Method 90 patients who received thyroid surgery in Taixing People's Hospital from April 2020 to April 2021 were selected. According to the results of random odd and even lot drawing, the observation group (odd lot, 45 cases) and the control group (even lot, 45 cases) were divided. The control group took routine care. The observation group implemented predictive care. The incidence of adverse reactions such as nausea and vomiting after surgery in the two groups were observed and counted, The changes of quality of life scores before and after nursing were evaluated. Result The incidences of nausea, vomiting, cough and

other adverse reactions in the observation group were significantly lower than those in the control group (P ＜ 0.05); At the same time, the scores of the corresponding items of the quality of life of the patients in the observation group after nursing were higher than those in the control group, with a significant difference (P ＜ 0.05). Conclusion Predictive nursing intervention combined with thyroid surgery can effectively prevent postoperative adverse reactions such as nausea and vomiting, and improve the quality of life of patients.

Analysis of the influence of Newman nursing mode on sleep quality and life quality of patients with colon cancer after operation

QIAN Wen

2023, 11(2):  50. 

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Objective To discuss the effect of Newman's nursing on the postoperative quality of sleep and life of patients with colon cancer. Method 82 patients with colon cancer who were admitted to Nanjing Liuhe District People's Hospital from January 2020 to February 2022 were selected and divided into the control group and the test group according to the random number table. The patients in the control group received routine nursing after operation, and the patients in the test group received Newman nursing after operation. The sleep quality and quality of life of the patients in the two groups were compared before and after nursing. Result In the comparison of sleep quality and quality of life scores, there was no significant difference between the two groups before nursing (P ＞ 0.05); After nursing, the sleep quality score of patients in the test group was lower than that of patients in the control group, and the quality of life score was higher than that of patients in the control group, with a significant difference

(P ＜ 0.05). Conclusion Newman nursing can improve the sleep quality and life quality of patients with colon cancer after operation.

Systematic overall nursing effect on the influence of postoperative edema and quality of life after surgery of perianal abscess

CHEN Jing, LIU Xinxin, ZHOU Dongfeng

2023, 11(2):  54. 

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Objective To explore the effect of systematic holistic nursing on postoperative wound edema and quality of life in patients with perianal abscess. Method From January 2019 to January 2020, there were 64 patients with perianal abscess surgery treated in Municipal Hospital of Qingdao. They were divided into observation groups and control groups according to the random digital table method. The control group is given conventional nursing, and the observation group gives systematic overall care. By investigating the wound edema situation, patient satisfaction, and quality of life of the two groups after nursing, the perianal wound edema score and health survey scale 36 were used to compare the nursing effects of the two groups. Result The edema scores of the observation group were significantly lower than the control group, and the difference was statistically significant (P ＜ 0.05).

The nursing satisfaction rate in the observation group was significantly higher than that in the control group; the physiological function, psychological function, and sleep quality of the observation group Self -care scores are higher than the control group, the differences were significant (P ＜ 0.05). Conclusion Systematic overall care for patients with perianal abscess can effectively improve the effect of surgery, reduce surgical wound edema, improve the quality of life of patients, and improve patient prognosis.

Effect of accelerated rehabilitation surgical nursing on self-care ability and pain level of patients with permanent colostomy after enhanced recovery after surgery

PAN Songyan

2023, 11(2):  57. 

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Objective To explore the impact of enhanced recovery after surgery (ERAS) nursing on self-care ability and pain in patients undergoing permanent colostomy for rectal cancer. Method From October 2019 to February 2022, 74 patients with permanent colostomy after rectal cancer surgery admitted to Nanjing Liuhe District People's Hospital were randomly divided into two groups using the digital table method. The control group had 37 patients receiving routine care, and the experimental group had 37 patients receiving ERAS care. Compare the self care ability and pain level of the two groups of patients. Result Before nursing, there was no significant difference in self care ability between the two groups (P ＞ 0.05); after nursing, the score of self care ability of patients in the experimental group was higher than that in the control group, with a significant difference (P ＜ 0.05). The VAS scores at 24h and 48h after surgery in the experimental group were (7.13±0.54) points and (4.30±0.29) points, respectively. The VAS scores at 24h and 48h after surgery in the control group were (7.20±0.41) points and (6.47±0.65) points, respectively. There was no significant difference in VAS scores between the two groups at 24 hours after surgery (t=0.628, P=0.532), but the VAS scores in the experimental group at 48 hours after surgery were significantly lower than those in the control group, with a significant difference (t=18.545, P ＜ 000.1). Conclusion ERAS nursing can significantly improve the self care ability of patients with permanent colostomy after rectal cancer surgery, and reduce their postoperative pain. The nursing effect is significant.