Abstract:

Objective To analyze the influence of positive circulating tumor cell (CTC) in peripheral blood of operable breast cancer patients on coagulation function in perioperative period. Method 80 cases of breast cancer patients who underwent surgical treatment in Zhanjiang Central People's Hospital from July 2019 to March 2020 were selected for the study. According to the level of tumor cells in their peripheral blood circulation, they were divided into positive group (preoperative CTC positive) and negative group (preoperative CTC negative). Before operation, on the 1st, 3rd, 7th and 14th day after operation, the patients were tested by routine coagulation function indexes and thromboelastogram. The results of coagulation function and thrombelastography were compared between the two groups. Result Among the 80 patients, 12 were positive for CTC, with a positive detection rate

of 15.00%. There were no significant difference in FIB and DD levels between positive group and negative group at different time before and after operation (P ＞ 0.05). The prothrombin time, activated partial thrombin time, thromboelastogram reaction time, and coagulation time in the positive group were significantly lower than those in the negative group, and the platelet count, thromboelastogram maximum amplitude, and Angle angle were significantly higher than those in the negative group, with significant differences (P ＜ 0.05). Conclusion Patients with operable breast cancer who have positive circulating tumor cells before operation have abnormal coagulation function during the perioperative period and have potential risk of deep vein thromboembolism.

Key words: Breast cancer surgery, Circulating tumor cell, Coagulation function, Relevance