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Journal of General Surgery for Clinicians    2024, 12 (2): 62-.   Abstract （37）            Knowledge map    Save Related Articles | Metrics

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Clinical eff ect analysis of improved totally extraperitoneal laparoscopic hernia repair in the treatment of inguinal hernia Li Qibiao, Li Dawei Journal of General Surgery for Clinicians    2024, 12 (2): 57-.   Abstract （34）            Knowledge map    Save Objective Analyze the clinical effi cacy of totally extraperitoneal laparoscopic hernia repair (TEP) in the treatment of inguinal hernia patients. Method Eighty male patients with initial inguinal hernia admitted to the Dongting Branch of Xishan People's Hospital in Wuxi from January 2018 to May 2023 were selected and divided into a control group (n=40, who underwent open tension-free hernia repair surgery) and an observation group (n=40, who underwent modifi ed TEP) based on diff erent surgical procedures. Analyze perioperative indicators, spermatic vein diameter, spermatic vein blood flow velocity, incidence of complications, and Nottingham health profile (NHP) scores for two groups of patients. Result The surgical time, hospitalization time, and anal exhaust time of the observation group patients were shorter than those of the control group, and the incidence of postoperative complications was lower than that of the control group, with signifi cant diff erences (P ＜ 0.05). Before surgery, there was no signifi cant diff erence in the diameter and blood fl ow velocity of the spermatic vein between the two groups of patients (P ＞ 0.05); Two weeks after surgery, the diameter of the spermatic vein in the observation group was smaller than that in the control group, and the blood fl ow velocity of the spermatic vein was faster than that in the control group, with a signifi cant diff erence (P ＜ 0.05). Before surgery, there was no signifi cant diff erence in NHP scores between the two groups of patients (P ＞ 0.05); Two weeks after surgery, the NHP scores in all dimensions of the two groups of patients decreased compared to before surgery, but the observation group was signifi cantly lower than the control group, with a signifi cant diff erence (P ＜ 0.05). Conclusion The improved TEP treatment for inguinal hernia patients has shown good therapeutic eff ects, minimal damage to the spermatic vein, and faster postoperative recovery. Related Articles | Metrics

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An appraisal of pancreatic cancer prognosis, immune infi ltration based on cuproptosis-related long noncoding RNA model and forecasting of traditional Chinese medicine Sun Guodong, Jiang Jingyi, Zhao Lei, Pu Weigao, Hu Jike, He Lijuan, Yun Zhangjun, Cheng Huijuan, Chen Hao, Journal of General Surgery for Clinicians    2024, 12 (2): 2-.   Abstract （55）            Knowledge map    Save Objective A prognostic model for pancreatic cancer(PC) based on cuproptosis-related long noncoding RNA (CRL) was constructed to predict the traditional Chinese medicine that regulates cuproptosis- related gene(CRG). Method A risk model for forecasting PC prognosis was constructed by utilizing Cox regression and Pearson correlation analysis, utilizing clinical data and RNA-seqs of 183 PC patients sourced from theTCGA. Screening CRL through LASSO regression, and the nomogram was formed by uniting the risk score and clinical features. To test the model's accuracy, receiver operator characteristic curve (ROC) and C-index were employed. An assessment was made of the correlation between risk scores and immunoinfi ltration and chemotherapy/targeted agents. The potential Chinese medicines for controlling CRG were predicted through the utilization of Coremine Medical database. Result The PC risk model was developed based on the risk scores of six CRLs (MIR1915HG, PRECSIT, AC004982.1, AC023043.4, AC010999.2, FOXCUT).The AUC for forecasting 1-year, 3-year and 5-year survival rates in PC patients was 0.782, 0.786 and 0.912 respectively, as revealed by the risk model, surpassing age, grade and TNM stage. A relationship was found between the risk score and the enrichment of tumor-infi ltrating lymphocytes, the presence of regulatory T cells, and the sensitivity of fourteen chemotherapeutic/targeted drugs. There are ninety-eight Chinese medicines that potentially regulate CRG; their eff ects primarily involve heat clearing and detoxifying properties attributed mainly to liver spleen and lung meridians. Traditional Chinese medicine Tenacissoside may have potential regulatory effects on key gene FDX1 involved in copper death mechanism. Conclusion A risk signature constructed based on six CRLs could assess the prognosis and immunity of PC, and Tenacissoside may have important regulatory effi cacy on the mechanism of coppercuproptosis. Related Articles | Metrics

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The eff ect of regorafenib combined with microwave ablation and transcatheter arterial chemoembolization in the treatment of primary liver cancer Chen Feng Journal of General Surgery for Clinicians    2024, 12 (4): 16-.   Abstract （21）            Knowledge map    Save Objective To investigate the efficacy of regorafenib combined with microwave ablation and percutaneous transhepatic arterial chemoembolization (TACE) in the treatment of primary liver cancer. Method Seventy four patients with primary liver cancer admitted to the Tianjin Second People's Hospital from October 2023 to April 2024 were selected and divided into an observation group and a control group using the medical record number envelope drawing method, with 37 patients in each group. The control group received microwave ablation combined with TACE treatment, while the observation group received regorafenib combined with microwave ablation and TACE treatment. The short-term efficacy, tumor markers, biomarkers, liver function, and adverse reactions of the two groups were compared. Result The disease control rate of the observation group patients was signifi cantly higher than that of the control group, and the diff erence was signifi cant (P ＜ 0.05). After treatment, the levels of cytokeratin 19, alpha fetoprotein, carcinoembryonic antigen, as well as alanine aminotransferase and alanine aminotransferase in the observation group were significantly lower than those in the control group. The levels of fragile histidine triad, P16 protein, and albumin were higher than those in the control group, and the diff erences were signifi cant (P ＜ 0.05). Nine patients in the observation group experienced adverse reactions, while ten patients in the control group experienced adverse reactions. There was no signifi cant diff erence in the incidence of adverse reactions between the two groups of patients (P ＞ 0.05). Conclusion Primary liver cancer treated with regorafenib combined with microwave ablation and TACE can improve short-term effi cacy, alleviate liver function damage, and with high safety. Related Articles | Metrics

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The eff ect of laparoscopic cholecystectomy on the levels of infl ammatory factors, pain scores, and incidence of complications in patients with acute calculous cholecystitis Guo Yingxi Journal of General Surgery for Clinicians    2024, 12 (4): 2-.   Abstract （52）            Knowledge map    Save Objective To investigate the eff ects of laparoscopic cholecystectomy on the levels of infl ammatory factors, pain scores, and incidence of complications in patients with acute cholecystitis caused by stones. Method Eighty patients with acute calculous cholecystitis who visited Shantou Chaonan Minsheng Hospital from June 2023 to June 2024 were randomly divided into a control group (small incision cholecystectomy) and a study group (laparoscopic cholecystectomy) using a random number table, with 40 patients in each group. Compare the levels of infl ammatory factors, pain scores, oxidative stress indicators, and incidence of complications between two groups. Result Before surgery, there was no signifi cant diff erence in the levels of interleukin-6, interleukin-8, C-reactive protein, tumor necrosis factor - α, as well as serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels between the two groups of patients (P ＞ 0.05). After surgery, the levels of interleukin-6, interleukin-8, C-reactive protein, tumor necrosis factor - α, and serum MDA in the study group were lower than those in the control group, but the level of SOD was higher than that in the control group, and the diff erences were signifi cant (P ＜ 0.05). At 12 hours, 1 day, and 3 days after surgery, the pain scores of patients in the study group were signifi cantly lower than those in the control group (P ＜ 0.05). The total incidence of postoperative complications in the study group (3.33%) was lower than that in the control group (13.33%), and the diff erence was signifi cant (P ＜ 0.05). Conclusion Laparoscopic cholecystectomy for the treatment of acute calculous cholecystitis can inhibit the body's inflammatory response and postoperative pain, reduce surgical stress response, and lower the risk of complications.  Related Articles | Metrics

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The application eff ect of fi ve tiered nutritional intervention in perioperative chemotherapy for gastrointestinal tumor patients Liang Quanjiang Journal of General Surgery for Clinicians    2024, 12 (2): 38-.   Abstract （59）            Knowledge map    Save Objective Exploring the effect of using five-tiered nutritional intervention in perioperative chemotherapy patients with gastrointestinal tumors. Method 88 patients with perioperative chemotherapy gastrointestinal tumors admitted to the Brain Hospital of Guangxi Zhuang Autonomous Region from February 2021 to February 2024 were selected. They were randomly divided into a reference group and a study group, with 44 cases in each group, using a random number table method. The reference group patients received routine dietary intervention, while the study group implemented fi ve-tiered nutritional intervention. The nutritional status, immune function indicators, tumor marker levels, improvement in nutritional levels, and bone marrow suppression results of the two groups of patients were observed before and after intervention. Result Before intervention, there was no signifi cant diff erence in nutritional related biochemical indicators, immune function indicators, tumor marker levels, and nutritional levels between the two groups of patients (P ＞ 0.05). After intervention, the nutritional related biochemical indicators, immune function indicators, tumor marker levels, and nutritional levels of the two groups of patients were signifi cantly improved (P ＜ 0.05). In addition, the levels of albumin, hemoglobin, transferrin, and prealbumin, CD3+, CD4+ T lymphocytes, IgM, IgA, and IgG in the study group were higher than those in the control group, and the PG-SGA score, CEA, and CA19-9 levels were lower than those in the control group, with signifi cant diff erences (P ＜ 0.05). After intervention, there was no signifi cant diff erence in the incidence of platelet and hemoglobin inhibition between the two groups of patients (P ＞ 0.05), but the incidence of white blood cell and granulocyte inhibition in the study group was lower than that in the control group, with a signifi cant diff erence (P ＞ 0.05). Conclusion Gastrointestinal tumor chemotherapy patients can be intervened with a fi ve-tiered nutritional guidance program during the perioperative period, which not only improves the patient’s nutritional level, but also improves their immune function, reduces the level of tumor markers, enhances anti-tumor ability, reduces bone marrow suppression, and alleviates chemotherapy adverse reactions during the perioperative period. It has a good nutritional intervention eff ect. Related Articles | Metrics

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Eff ect of diff erent pneumoperitoneum pressure on the quality of recovery period after laparoscopic radical resection of colorectal cancer patients Huang Liqing, Li Xiaomin, Wen Xiaoling Journal of General Surgery for Clinicians    2024, 12 (4): 22-.   Abstract （28）            Knowledge map    Save Objective To investigate the effects of different pneumoperitoneum pressures on patients undergoing laparoscopic colorectal cancer surgery (LCS) and their impact on the quality of postoperative recovery period. Method 70 patients with LCS admitted to Gaozhou Traditional Chinese Medicine Hospital from October 2022 to October 2023 were selected and divided into a control group (controlled at 13 ～ 15mmHg) and an observation group (controlled at 8 ～ 12mmHg) based on diff erent levels of artifi cial pneumoperitoneum pressure, with 35 patients in each group. Result Compare the quality of recovery, cognitive function, stress response indicators, and gastrointestinal function recovery between two groups of patients. There was no significant diff erence in extubation time and anesthesia recovery time between the two groups of patients (P ＞ 0.05). The incidence of agitation during the awakening period in the observation group was lower than that in the control group, and the recovery of bowel sounds, anal exhaust, and postoperative fasting time were shorter than those in the control group, with signifi cant diff erences (P ＜ 0.05). The scores of the simple mental state examination scale for both groups of patients on postoperative day 1, 3, and 7 were lower than those on preoperative day 1, and the scores of the observation group were higher than those of the control group, with signifi cant diff erences (P ＜ 0.05). Compared with T0, the levels of cortisol and C-reactive protein in both groups increased from T1 to T3, and the levels of cortisol and C-reactive protein in the observation group were lower than those in the control group at the same time, with signifi cant diff erences (P ＜ 0.05). Conclusion Compared with high pneumoperitoneum pressure, adopting low pneumoperitoneum pressure in LCS treatment has less impact on patients' cognitive function, gastrointestinal function, and stress response, and can reduce the risk of agitation during the recovery period. Related Articles | Metrics

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Clinical analysis of diff erent methods of tension-free hernia repair for the treatment of inguinal hernia Xu Wenqiang Journal of General Surgery for Clinicians    2024, 12 (4): 27-.   Abstract （37）            Knowledge map    Save Objective To explore the clinical effi cacy of laparoscopic plain tension-free hernia repair and hernia ring filling tension-free hernia repair in the treatment of inguinal hernia. Method Ninety patients with inguinal hernia admitted to Qingyang Hospital in Jiangyin City from January 2021 to December 2023 were selected and divided into a study group and a routine group, with 45 patients in each group, based on diff erent surgical methods. The conventional group underwent tension-free hernia repair with hernia ring filling, while the study group underwent laparoscopic plain mesh tension-free hernia repair. The surgical related indicators, treatment outcomes,and complications of the two groups were compared. Result The overall treatment effi cacy rate of the study group patients (97.78%) was significantly higher than that of the conventional group (75.56%). The surgical duration and postoperative time to get out of bed of the study group patients were shorter than those of the conventional group, and the intraoperative blood loss was less than that of the conventional group, with signifi cant diff erences (P ＜ 0.05). The incidence of complications in the study group was 2.22% (1/45), signifi cantly lower than that in the conventional group [6.67% (3/45)], and the difference was significant (χ2=4.406, P=0.036). Conclusion Laparoscopic plain fi lm tension-free hernia repair is safe and eff ective in the treatment of inguinal hernia, with a lower risk of complications. Related Articles | Metrics

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Exploration of the impact of preventive nursing in operating rooms on pressure injuries in elderly surgical patients Zhu Shenglong, Li Tianxing, Chen Qi Journal of General Surgery for Clinicians    2024, 12 (4): 46-.   Abstract （39）            Knowledge map    Save Objective To explore the value of implementing operating room nursing in reducing the incidence of surgical pressure injuries. Method Sixty surgical patients admitted to Guangzhou University of Traditional Chinese Medicine Meizhou Hospital from March 2022 to November 2023 were collected and randomly divided into a control group and an observation group, with 30 patients in each group, using a random number table method. The control group received routine operating room care, while the observation group received preventive care in the operating room. The incidence of pressure ulcers, pressure ulcer risk assessment, and patient satisfaction were evaluated in both groups. Result The incidence of pressure ulcers in the observation group was lower than that in the control group, the area of pressure ulcers was smaller than that in the control group, and the patient satisfaction was higher than that in the control group, with signifi cant diff erences (P ＜ 0.05). The Braden scores of the observation group patients before and after nursing were (13.36±2.66) and (19.27±2.47) points, respectively, while the Braden scores of the control group patients before and after nursing were (13.28±2.56) and (16.23±2.25) points, respectively. After nursing, the Braden scores of both groups increased compared to before nursing, and the Braden scores of patients in the observation group were higher than those in the control group, with a signifi cant difference (t=4.984, P ＜ 0.001). Conclusion Scientific evaluation of pressure injuries and the development of corresponding operating room nursing plans based on the actual situation of elderly patients can help reduce the risk of pressure ulcers and improve patient satisfaction. Related Articles | Metrics

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Application of selective portal vein staining combined with hepatic lobe blood flow obstruction in right lobe anatomical hepatectomy Chen Haimin, Zhu Qingsheng Journal of General Surgery for Clinicians    2025, 13 (1): 16-.   Abstract （37）            Knowledge map    Save Objective To investigate the application eff ect of hepatic lobe blood fl ow obstruction combined with selective portal vein staining in right lobe anatomical liver resection. Method The research subjects were 82 patients who underwent right lobe anatomical liver resection at Yuebei People’s Hospital from January 2022 to October 2023. They were randomly divided into two groups, an experimental group and a control group, with 41 pa-tients in each group. The experimental group received hepatic lobe blood flow obstruction, while the control group received the Pringle method of fi rst porta hepatis obstruction. Portal vein staining was performed in both groups to compare the therapeutic eff ects. Result There was no signifi cant diff erence in surgical time between the two groups of patients (P ＞ 0.05), but the experimental group had a shorter hospital stay and less intraoperative bleeding than the control group, with signifi cant diff erences (P ＜ 0.05). Before surgery, there was no signifi cant diff erence in liver function indicators between the two groups of patients (P ＞ 0.05); After surgery, the total albumin level in the experimental group was higher than that in the control group, and the total bilirubin and alanine aminotransferase levels were lower than those in the control group, with signifi cant diff erences (P ＜ 0.05). There was no signifi cant diff erence in the incidence of postoperative bile leakage, bleeding, and infection between the two groups of patients (P ＞ 0.05), but the incidence of hepatic vein injury in the experimental group was lower than that in the control group, and the recurrence rate was lower than that in the control group after 6 months of follow-up, with signifi cant diff erences (P ＜ 0.05). Conclusion The combination of hepatic lobe blood flow obstruction and portal vein stain-ing can reduce intraoperative bleeding and lower the incidence of postoperative complications in right lobe anatom-ical liver resection. It is a safe and feasible treatment method. Related Articles | Metrics

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Journal of General Surgery for Clinicians    2024, 12 (4): 53-.   Abstract （19）            Knowledge map    Save Related Articles | Metrics

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The clinical eff ect of applying the nursing mode of day surgery ward to patients undergoing laparoscopic tension-free inguinal hernia repair surgery Chen Tingting Journal of General Surgery for Clinicians    2024, 12 (4): 34-.   Abstract （27）            Knowledge map    Save Objective To explore the eff ect of nursing mode in the day surgery ward on patients undergoing laparoscopic tension-free inguinal hernia repair. Method A retrospective analysis was conducted on 117 patients who underwent laparoscopic tension-free inguinal hernia repair surgery at Lufeng People's Hospital from January 2022 to January 2024. The patients were divided into an inpatient surgery group (59 cases, intervened with conventional nursing methods) and a daytime surgery group (58 cases, intervened with nursing mode in the daytime surgery ward) according to diff erent surgical times. Result The diff erences in intraoperative bleeding, hospitalization time, daytime mobilization time, and incidence of complications between the two groups were compared. The results showed that the postoperative hospitalization time, surgery time, and postoperative mobilization time of patients in the daytime surgery group were shorter than those in the inpatient surgery group, and the intraoperative bleeding and total consumption were both less than those in the inpatient surgery group, with signifi cant diff erences (P ＜ 0.05). The total incidence of complications in the daytime surgery group (22.41%) was signifi cantly lower than that in the inpatient surgery group (47.46%), and the diff erence was signifi cant (P ＜ 0.05). Conclusion The intervention of nursing mode in the daytime surgical ward can signifi cantly improve the clinical treatment eff ect of patients undergoing laparoscopic lower abdominal inguinal hernia repair, with lower complications. Related Articles | Metrics

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The eff ect and impact of placing drainage tubes after laparoscopic cholecystectomy for the treatment of acute suppurative cholecystitis Song Yunpeng Journal of General Surgery for Clinicians    2024, 12 (2): 43-.   Abstract （39）            Knowledge map    Save Objective To explore the eff ect of placing drainage tubes or not after laparoscopic cholecystectomy (LC) on the treatment of acute suppurative cholecystitis and its impact on traumatic inflammatory response. Method 86 patients with acute suppurative cholecystitis admitted between January 2022 and September 2023 were all treated with LC. They were divided into groups based on whether to place a drainage tube after surgery. Group A had 43 patients who did not place a drainage tube after surgery, while Group B had 43 patients who placed a drainage tube after surgery. The perioperative indicators, infl ammatory indicators, and postoperative complications between two groups were compared. Result The postoperative anal exhaust time, mobilization time, and hospitalization time of Group A patients were shorter than those of Group B, with signifi cant diff erences (P＜ 0.05). There was no signifi cant diff erence in preoperative C-reactive protein, white blood cell count, and interleukin-6 levels between the two groups of patients (P ＞ 0.05); 3 days after surgery, the levels of the above indicators in Group A were better than those in Group B, with signifi cant diff erences (P ＜ 0.05). The incidence of postoperative incision pain, infection, bile leakage, and shoulder pain in Group A patients was signifi cantly lower than that in Group B (P ＜ 0.05). Conclusion Patients with acute suppurative cholecystitis who undergo LC without placement of drainage tubes can shorten their postoperative recovery time and reduce the risk of complications. Related Articles | Metrics

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A comparative study on the clinical treatment eff ect of circular areola and radial incision surgery on patients with breast fi broadenoma Ou Zhike, Huang Dongxi, Hou Yugen, Wu Zhanjia Journal of General Surgery for Clinicians    2024, 12 (3): 23-.   Abstract （53）            Knowledge map    Save Objective To explore the clinical effi cacy of using circular areola and radial incision treatment for benign breast tumors. Method Fifty patients with benign breast tumors admitted to our hospital from September 2019 to January 2024 were divided into two groups using a random number table method, with 25 cases in each group. The research group underwent circumareolar incision surgery, while the control group underwent radial incision surgery. Compare the clinical efficacy, perioperative indicators, breast aesthetics score, sensory nerve function in the areola area, and complications between two groups. Result Compared with the control group, the study group had a higher overall treatment effi cacy, shorter surgical scar length, longer surgical time, more bleeding, higher satisfaction with breast aesthetics, better postoperative recovery of sensory nerve function in the areola area, and lower incidence of complications, with signifi cant diff erences (P ＜ 0.05). Conclusion Both types of incision surgery can eff ectively treat benign breast tumors. However, patients undergoing circumareolar incision surgery have smaller residual scars on the body surface, resulting in better treatment outcomes. Additionally, postoperative patients have a higher satisfaction with breast aesthetics and will not aff ect the sensory nerve function in the areola area. With fewer complications, it is safe and reliable. Related Articles | Metrics

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Clinical effi cacy analysis of diff erent closure methods of residual appendix in laparoscopic appendectomy Zhang Shengyuan Journal of General Surgery for Clinicians    2024, 12 (3): 41-.   Abstract （56）            Knowledge map    Save Objective To analyze analyze the clinical eff ects of diff erent closure methods for appendiceal stump during laparoscopic appendectomy. Method A retrospective analysis was conducted on the clinical data of 280 patients who underwent laparoscopic appendectomy at the Second People's Hospital of Xining City from January 2023 to January 2024. The appendiceal stump was divided into two groups based on diff erent treatment methods: the observation group was treated with Hem-o-lok clamp, and the control group was treated with purse string embedding, with 140 patients in each group. Observe the recovery level, length of hospital stay, and postoperative complications of two groups of patients. Result The surgical time, hospitalization time, and anal exhaust time of the observation group patients were shorter than those of the control group, but the hospitalization costs were higher than those of the control group, and the diff erences were signifi cant (P ＜ 0.05). There was no signifi cant diff erence in the total incidence of postoperative complications between the two groups of patients (P ＞ 0.05). Conclusion The use of Hem-o-lok clamping technology can better treat residual appendicitis and improve the recovery speed of patients. Due to its low complication rate, it has advantages over using purse string embedding technology, but the cost may be more expensive. Related Articles | Metrics

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The impact of laparoscopic cholecystectomy on gastrointestinal quality of life in patients with gallstones and choledocholithiasis Huang Chaoguo, Mai Guanbao, Wu Shangcong Journal of General Surgery for Clinicians    2024, 12 (3): 32-.   Abstract （47）            Knowledge map    Save Objective To explore the impact of laparoscopic cholecystectomy on the gastrointestinal quality of life in patients with gallstones and common bile duct stones. Method 100 patients with gallstones and choledocholithiasis who received treatment at Wuchuan People's Hospital from March 2022 to March 2024 were selected and randomly divided into a control group and an observation group, with 50 cases in each group, using a random number table. The control group was treated with traditional surgical methods, while the observation group was treated with laparoscopic cholecystectomy. The gastrointestinal quality of life, infl ammatory indicators, and liver function of the two groups of patients were compared before and 3 days after surgery. Result Before surgery, there was no signifi cant diff erence in the gastrointestinal quality of life scores between the two groups of patients [the control group (79.25±4.73) points compared to the observation group (80.21±4.77) points, t=1.011，P=0.315]. On postoperative day 3, the gastrointestinal quality of life score of the observation group was (137.86±6.33), signifi cantly higher than that of the control group (122.19±6.48), and the diff erence was signifi cant (t=12.233, P ＜ 0.001). On postoperative day 3, the levels of CRP, TNF-α, and white blood cell count in both groups increased compared to preoperative levels, but the values in the observation group were lower than those in the control group, and the difference was significant (P ＜ 0.001). On postoperative day 3, the levels of γ-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase in both groups decreased compared to preoperative levels, and the values in the observation group were higher than those in the control group, with signifi cant diff erences (P ＜ 0.001). Conclusion The application of laparoscopic cholecystectomy in the treatment of patients with gallstones and common bile duct stones can improve their postoperative gastrointestinal quality of life, reduce their postoperative infl ammatory response, and alleviate the impact of surgery on their liver function. Related Articles | Metrics

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Journal of General Surgery for Clinicians    2024, 12 (3): 49-.   Abstract （35）            Knowledge map    Save Related Articles | Metrics

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Evaluation of the eff ect of abdominal compression on the prevention of hypoxemia during painless gastroscopy Liu Jiuyue, Jin Xianglan , Wang Huazhen, Wang Yang, Bi Hehui, Wang Shiyan, Journal of General Surgery for Clinicians    2024, 12 (2): 34-.   Abstract （33）            Knowledge map    Save Objective To observe the effect of abdominal compression operation in preventing hypoxemia in painless gastroscopy anesthesia. Method 188 patients who underwent painless gastroscopy examination in the outpatient and inpatient departments of Yanbian University Affi liated Hospital from September 2021 to November 2022 were randomly divided into an observation group and a control group, with 94 patients in each group, using a random number table method. The control group was treated with nasal cannula oxygen inhalation, while the observation group was assisted with abdominal compressions on the basis of the control group. The lowest pulse oxyhemoglobin saturation (SpO2) level, incidence of hypoxemia, gastroscopy examination time, incidence of withdrawal and suspension of examination, total amount of propofol used, awakening time, and incidence of postoperative adverse reactions were compared between the two groups of patients. Result The lowest SpO2 level of the observation group patients was higher than that of the control group, and the gastroscopy examination time was shorter than that of the control group. The incidence of dropout and hypoxemia were both lower than those of the control group, and the diff erences were signifi cant (P ＜ 0.05). However, there was no signifi cant diff erence in heart rate and incidence of adverse reactions between the two groups of patients when they reached the lowest SpO2 level (P ＞ 0.05). Conclusion Abdominal compression operation can eff ectively prevent the occurrence of hypoxemia in painless gastroscopy, maintain a high SPO2 level, shorten the time of gastroscopy, and improve the effi ciency of gastroscopy. Related Articles | Metrics

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Clinical application of bevacizumab combined with chemotherapy in targeted treatment of colorectal cancer Zeng Guowei Journal of General Surgery for Clinicians    2024, 12 (2): 47-.   Abstract （73）            Knowledge map    Save Objective To explore the application effect of bevacizumab combined with chemotherapy in targeted therapy for colorectal cancer. Method A retrospective analysis was conducted on the clinical data of 68 patients with colorectal cancer admitted to Guangzhou Baiyunshan Hospital from June 2022 to June 2023. They were divided into a control group (chemotherapy, 33 cases) and a study group (bevacizumab+chemotherapy, 35 cases) based on diff erent treatment plans. The therapeutic effi cacy, tumor marker levels, and incidence of adverse reactions were compared between the two groups of patients. Result The disease control rate of the study group patients was 94.29%, higher than that of the control group (72.73%), with a significant difference (P ＜ 0.05). Before treatment, there was no signifi cant diff erence in the levels of carbohydrate antigen (CA) 19-9, CA 72-4, and carcinoembryonic antigen between the two groups (P ＞ 0.05); After treatment, the average levels of CA 19-9, CA 72-4, and carcinoembryonic antigen in the study group were signifi cantly lower than those in the control group (P ＜ 0.05). There was no signifi cant diff erence in the total incidence of adverse reactions between the two groups of patients (P ＞ 0.05). Conclusion Bevacizumab combined with chemotherapy can signifi cantly improve the disease control rate of colorectal cancer patients, reduce the level of tumor markers in the body, and there is no increase in the risk of adverse reactions. Related Articles | Metrics

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The impact of laparoscopic radical resection of colorectal cancer on liver and kidney function Liao Lingzhou, Mo Yuandong Journal of General Surgery for Clinicians    2024, 12 (2): 52-.   Abstract （33）            Knowledge map    Save Objective To analyze the impact of laparoscopic radical resection of colorectal cancer on liver and kidney function in patients. Method 120 patients with colorectal cancer who received treatment at Rong’an County People’s Hospital in Liuzhou City from March 2021 to March 2023 were selected and randomly divided into a control group and an experimental group (each with 60 cases) using a random number table method. The control group received traditional open surgery, while the experimental group received laparoscopic radical resection for colorectal cancer. The liver and kidney function indicators and postoperative complications of the two groups of patients were compared. Result On the fi rst day before surgery, there was no signifi cant diff erence in liver and kidney function indicators between the two groups of patients (P ＞ 0.05). Three days after surgery, the lactate dehydrogenase levels in the experimental group patients increased signifi cantly compared to the fi rst day before surgery (P ＜ 0.05); The total protein, cholinesterase, and albumin levels of the experimental group patients were signifi cantly lower than those of the control group, and the uric acid level was signifi cantly lower than that of the control group, with signifi cant diff erences (P ＜ 0.05). The incidence of postoperative complications in the experimental group was signifi cantly lower than that in the control group (5.00% vs. 16.67%; P=0.040). Conclusion Laparoscopic radical surgery for colorectal cancer can impose a burden on the liver function of patients and have a smaller impact on their renal function. Compared to traditional open surgery, the risk of complications is lower. Related Articles | Metrics