Abstract:

Objective To explore the impact of laparoscopic cholecystectomy on the gastrointestinal quality of life in patients with gallstones and common bile duct stones. Method 100 patients with gallstones and choledocholithiasis who received treatment at Wuchuan People's Hospital from March 2022 to March 2024 were selected and randomly divided into a control group and an observation group, with 50 cases in each group, using a random number table. The control group was treated with traditional surgical methods, while the observation group was treated with laparoscopic cholecystectomy. The gastrointestinal quality of life, infl ammatory indicators, and liver function of the two groups of patients were compared before and 3 days after surgery. Result Before surgery, there was no signifi cant diff erence in the gastrointestinal quality of life scores between the two groups of patients [the control group (79.25±4.73) points compared to the observation group (80.21±4.77) points, t=1.011，P=0.315]. On postoperative day 3, the gastrointestinal quality of life score of the observation group was (137.86±6.33), signifi cantly higher than that of the control group (122.19±6.48), and the diff erence was signifi cant (t=12.233, P ＜ 0.001). On postoperative day 3, the levels of CRP, TNF-α, and white blood cell count in both groups increased compared to preoperative levels, but the values in the observation group were lower than those in the control group, and the difference was significant (P ＜ 0.001). On postoperative day 3, the levels of γ-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase in both groups decreased compared to preoperative levels, and the values in the observation group were higher than those in the control group, with signifi cant diff erences (P ＜ 0.001). Conclusion The application of laparoscopic cholecystectomy in the treatment of patients with gallstones and common bile duct stones can improve their postoperative gastrointestinal quality of life, reduce their postoperative infl ammatory response, and alleviate the impact of surgery on their liver function.

Key words: Laparoscopic cholecystectomy, Gallstones, Choledocholithiasis, Gastrointestinal quality of life