Abstract:

Objective Exploring the effect of using five-tiered nutritional intervention in perioperative chemotherapy patients with gastrointestinal tumors. Method 88 patients with perioperative chemotherapy gastrointestinal tumors admitted to the Brain Hospital of Guangxi Zhuang Autonomous Region from February 2021 to February 2024 were selected. They were randomly divided into a reference group and a study group, with 44 cases in each group, using a random number table method. The reference group patients received routine dietary intervention, while the study group implemented fi ve-tiered nutritional intervention. The nutritional status, immune function indicators, tumor marker levels, improvement in nutritional levels, and bone marrow suppression results of the two groups of patients were observed before and after intervention. Result Before intervention, there was no signifi cant diff erence in nutritional related biochemical indicators, immune function indicators, tumor marker levels, and nutritional levels between the two groups of patients (P ＞ 0.05). After intervention, the nutritional related biochemical indicators, immune function indicators, tumor marker levels, and nutritional levels of the two groups of patients were signifi cantly improved (P ＜ 0.05). In addition, the levels of albumin, hemoglobin, transferrin, and prealbumin, CD3+, CD4+ T lymphocytes, IgM, IgA, and IgG in the study group were higher than those in the control group, and the PG-SGA score, CEA, and CA19-9 levels were lower than those in the control group, with signifi cant diff erences (P ＜ 0.05). After intervention, there was no signifi cant diff erence in the incidence of platelet and hemoglobin inhibition between the two groups of patients (P ＞ 0.05), but the incidence of white blood cell and granulocyte inhibition in the study group was lower than that in the control group, with a signifi cant diff erence (P ＞ 0.05). Conclusion Gastrointestinal tumor chemotherapy patients can be intervened with a fi ve-tiered nutritional guidance program during the perioperative period, which not only improves the patient’s nutritional level, but also improves their immune function, reduces the level of tumor markers, enhances anti-tumor ability, reduces bone marrow suppression, and alleviates chemotherapy adverse reactions during the perioperative period. It has a good nutritional intervention eff ect.

Key words: Gastrointestinal tumors, Perioperative；Chemotherapy, Five-tiered nutritional intervention, Treatment eff ect