Table of Content

01 April 2022, Volume 10 Issue 2

Previous Issue   

Effect of total thyroidectomy and unilateral thyroidectomy in the treatment of T1 and T2 differentiated thyroid cancer

HE Jingliang, HUANG Jinlin, MAI Shuyan

2022, 10(2):  2. 

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Objective To investigate the effect of total thyroidectomy and unilateral lobectomy in the treatment of T1 and T2 differentiated thyroid cancer. Method 72 patients with T1 and T2 differentiated thyroid cancer treated in Shunde Hospital Guangzhou University of Chinese Medicine from January 2016 to July 2020 were selected as the research objects, and they were divided into groups according to their different surgical methods. 32 patients in the control group underwent total thyroidectomy; total thyroidectomy was performed in 40 cases in the experimental group. The treatment effect, operation index, hospital stay,complication rate and disease recurrence of the two groups were analyzed. Result The total effective rate was 93.8% in the control group and 95.0% in the experimental group. There was no significant difference between the two groups (P ＞ 0.05); The operation time, bleeding volume and complications in the control group were lower than those in the experimental group (P ＜ 0.05). There was no significant difference in the amount of bleeding and postoperative hospital stay between the two groups (P ＞ 0.05), and there was no significant difference in the short-term recurrence rate (P ＞ 0.05). Conclusion Total thyroidectomy and unilateral thyroidectomy have certain value in the treatment of patients with T1 and T2 differentiated thyroid cancer. Unilateral total thyroidectomy can reduce the amount of bleeding, operation time and complication rate, and the short-term treatment effect is the same as that of total thyroidectomy.

A signature for predicting the prognosis of breast cancer based on aging-related genes

LI Xiaoping, QIU Chaoran, YU Qihe, CHEN Qiyang, FANG Yuewan

2022, 10(2):  6. 

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Objective To screen out the aging genes that are significantly related to the prognosis of breast cancer through bioinformatics. Method Clinical data and mRNA sequencing data were downloaded from the cancer genome atlas (TCGA) database collected by the National Cancer Center from September, 2010 to June, 2015. Aging genes were downloaded from the Aging Atlas database. Differential express genes between the normal tissue and the cancer tissue were compared. Single factor Cox and Lasso regression were applied to obtain prognostic-related aging genes. Then the signature was constructed, the patients were divided into high-risk group and low-risk group with the median of risk coefficient as the cut-off value. Univariate and multivariate regression were used to identify the independent factor, then Nomogram was constructed. Gene set enrichment analysis (GSEA) software was used for the functional enrichment analysis of key genes. Result 119 differential aging genes and 10 prognostic-related genes were obtained, including 2 tumor suppressor genes(NRG1, IL2RG) and 8 cancer-promoting genes (EIF4EBP1,MMP1, PLAU, MMP13, RAD51, FGF7, DLL3, IGFBP1). The 10-aging-gene signature was constructed by Cox. The prognosis between the high risk and low risk group was significantly differently. The Nomogram showed good performance in predicting the overall survival of breast cancer patient. The GSEA showed the high-risk group was significantly enriched in signal pathways such as cell cycle and homologous recombination. The genes of lowrisk group was significantly enriched in the JAK-STAT signaling pathway, cytokine-receptor-interaction pathway. Conclusion The signature based on aging related genes had a good performance on predicting the prognosis of breast cancer patients.

A comparative study of combined double endoscopy and laparotomy in the treatment of cholecystolithiasis complicated with common bile duct stones

YUAN Fei, QIAN Gang, MAO Yefei, HE Jun

2022, 10(2):  13. 

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Objective To investigate the clinical effect of double-endoscopy combined with open surgery in patients with cholecystolithiasis complicated with common bile duct stones. Method From July 2018 to October 2021, 72 patients with cholecystolithiasis complicated with common bile duct stones in Zhangjiagang Third People's Hospital were randomly divided into groups, patients treated with open surgery alone were the control group, and patients treated with double-endoscopy combined technique were selected as the observation group,36 cases in each group. In the observation group, clinical indicators such as operation time were recorded, postoperative complications were counted, and differences in postoperative long-term efficacy were evaluated. Result The operation time, intraoperative blood loss and postoperative exhaust time of the observation group were significantly better than those of the control group (P ＜ 0.05). It was lower than that of the control group (16.67%, P ＜ 0.05); the excellent and good rate of the observation group was 100%, which was significantly better than that of the control group (88.89%, P ＜ 0.05). Conclusion Compared with traditional laparotomy, patients with cholecystolithiasis and common bile duct stones treated with dual-endoscope combined technique have significantly better surgical effect and less injury.

Study on the effect of laparoscopic radical resection of colorectal cancer in the treatment of elderly colorectal cancer

YE Nianyuan, XI Cheng, WANG Yibo, ZHANG Zheng

2022, 10(2):  17. 

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Objective To explore the clinical effect of laparoscopic radical resection of colorectal cancer in the elderly. Method 100 elderly patients with colorectal cancer treated in Wujin Hospital Affiliated to Jiangsu University from December 2016 to March 2021 were selected as the research object. They were divided into control group (n=50) and study group (n=50) by different surgical methods. The patients in the control group were treated with traditional open surgery, and the patients in the study group were treated with laparoscopic radical resection of colorectal cancer. The operation implementation, postoperative complications, quality of life and gastrointestinal function were compared between the two groups. Result The scores of postoperative quality of life in the two groups were significantly higher than those before intervention, and the scores of patients in the study group were higher than those in the control group (P ＜ 0.05); the incidence of postoperative complications in the study group was 14.00%, which was significantly lower than that in the control group (P ＜ 0.05); during the operation, the operation time, intraoperative bleeding, postoperative exhaust time, postoperative hospital stay and resection length in the study group were significantly better than those in the control group (P ＜ 0.05); the levels of motilin and gastrin in the study group were significantly higher than those in the control group (P ＜ 0.05). Conclusion The clinical effect of laparoscopic radical resection of colorectal cancer in elderly patients is better. It can effectively reduce the incidence of complications in elderly patients, with less trauma and higher safety. It is of positive significance to improve the quality of life of elderly patients with colorectal cancer.

Comparison of the clinical efficacy of laparoscopic and open abdominal surgery for colorectal cancer

XU Liangming

2022, 10(2):  21. 

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Objective To investigate the clinical efficacy of laparoscopic and open surgery in the treatment of colorectal cancer. Method 74 patients with colorectal cancer who underwent surgery in Nanjing Gaochun People's Hospital from January 2021 to December 2021 were divided into study group (laparoscopic surgery) and control group (open surgery) according to different surgical methods,37 cases in each group . The postoperative related conditions and curative effects of the two groups were compared. Result The operation time, hospital stay, postoperative anal exhaust time, getting out of bed time and postoperative eating time in the study group were shorter than those in the control group, and the amount of intraoperative bleeding was less than that in the control group (P ＜ 0.05); The incidence of postoperative complications in the study group was lower than that in the

control group (P ＜ 0.05). Conclusion Both laparoscopic and open surgery have good results in the treatment of colorectal cancer, but laparoscopy has less trauma, higher safety and can promote the rapid recovery of patients.

Clinical evaluation of laparoscopic and traditional open surgery in the treatment of colorectal cancer

WANG Wenying

2022, 10(2):  24. 

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Objective To compare the clinical efficacy and postoperative complications of traditional laparotomy and laparoscopic surgery in patients with colorectal cancer. Method A total of 60 patients with colorectal cancer admitted to our hospital from January 2018 to September 2021 were selected as the research subjects, and were divided into traditional open surgery group (control group) and laparoscopic surgery group (observation group) by different surgical methods, with 30 patients in each group. The clinical treatment effects of the two groups were compared, and the oxidative stress level and postoperative complications were compared before and 3 days after surgery. Result The amount of intraoperative bleeding in the observation group was (70.35±23.32)ml, which was less than that in the control group (164.83±43.24)ml. The operation time was (146.48±15.34)

min, the recovery time of intestinal function was (60.35±13.43)h and the hospital stay was (11.83±5.32)d, which were shorter than those in the control group (P ＜ 0.05). Before treatment, there was no significant difference in the levels of superoxide dismutase(SOD) and serum malondialdehyde(MDA) between the two groups (P ＞ 0.05); after treatment, the levels of SOD and MDA in the observation group were (85.30±12.99)kU/L and (6.01±1.83)mmol/L respectively, and those in the control group were (74.81±11.23)kU/L and (7.29±1.92)mmol/L respectively (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion Laparoscopic surgery is better than open surgery in the treatment of colorectal cancer, the patients have less trauma, rapid recovery and high safety.

Clinical evaluation of preserving left colonic artery in laparoscopic radical resection of rectal cancer in elderly patients with rectal cancer

WANG Shuwei, LI Gan, JING Fa

2022, 10(2):  28. 

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Objective To investigate the clinical effect of precise preservation of left colonic artery in laparoscopic surgery in elderly patients with rectal cancer. Method 68 elderly patients with rectal cancer treated in Wuxi traditional Chinese medicine hospital from May 2017 to August 2021 were selected as the research object. According to different operation methods, they were divided into 30 cases in the control group (without retaining the left colonic artery during operation) and 38 cases in the experimental group (retaining the left colonic artery during operation). The operation indexes and postoperative recovery of the two groups were compared. Result There was no significant difference in intraoperative bleeding (P=0.774), total number of lymph nodes

cleaned (P=0.642), number of lymph nodes cleaned (P=0.571) and anastomotic bleeding (P=0.865) between the experimental group and the control group (P ＞ 0.05), but the operation time of the experimental group was longer (P=0.003), the postoperative hospital stay and anal ventilation time were shorter than those of the control group (P=0.006 and 0.001 respectively), and the incidence of anastomotic leakage was also lower than that of the control group (P=0.046). Conclusion For elderly patients with rectal cancer, preserving the left colonic artery during laparoscopic radical resection has no negative impact on the efficiency of lymph node dissection, and the risk of bleeding has not increased. At the same time, it can effectively shorten the postoperative exhaust time and reduce the incidence of anastomotic leakage.

Anesthesia and analgesia effect of ultrasound-guided nerve block with different routes in breast cancer patients and its influence on cognitive function

LI Kaihui

2022, 10(2):  32. 

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Objective To investigate the effect of anesthesia and analgesia and the influence on cognitive function of different routes of nerve block guided by ultrasound in breast cancer patients. Method A total of 100 breast cancer patients admitted to the 73rd Group Military Hospital of the PLA Army from January 2020 to January 2021 were selected and divided into a control group (intercostal nerve block + general anesthesia, 50 patients) and observation group (50 cases with chest wall nerve block + general anesthesia)by different surgical methods. The anesthesia and analgesia effect, cognitive function and occurrence of adverse reactions were compared between the two groups. Result Compared with the control group, the pain scores of patients in the observation group were significantly lower after leaving the recovery room and 24 hours after operation (P ＜ 0.05); after operation, the level of cognitive function in the observation group was significantly higher than that in the control group (P

＜ 0.05); the incidence of adverse reactions in the observation group was 8.00%, significantly lower than 24.00% in the control group (P ＜ 0.05). Conclusion For breast cancer patients, the use of chest wall nerve block has achieved good results in analgesia, greatly improved the patient's cognitive function, reduced the adverse reaction rate.

Clinical significance and related research progress of recurrent laryngeal nerve

LU Jianfei, JIANG Fangqian, CAO Yifan, YAO Tingjing

2022, 10(2):  36. 

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With the increasing incidence of thyroid cancer, thyroid surgery has become an important surgical treatment for thyroid diseases. The recurrent laryngeal nerve into the larynx is easily damaged due to its unique location and complicated anatomy. The protection of recurrent laryngeal nerve into the larynx is often the most important part of thyroid surgery. In this paper, based on the research status and progress at home and abroad, combined with clinical practice, the relevant situation and intraoperative treatment of recurrent laryngeal nerve into the larynx were summarized, aiming to provide help for clinical work.

Analysis of the incidence and related factors of hypoparathyroidism after thyroidectomy

SHI Qifeng, ZHU Xionglin, JIN Yizhuan, CHENG Yuepeng

2022, 10(2):  41. 

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Objective To investigate the related factors of hypoparathyroidism after thyroidectomy. Method The clinical data of 150 patients who underwent thyroidectomy in Wuhan Xinzhou District People's Hospital from January 2018 to March 2020 were analyzed retrospectively. According to whether there was hypoparathyroidism after operation, they were divided into hypoparathyroidism group (29 cases) and normal function group (121 cases). The incidence of hypoparathyroidism after thyroidectomy was counted, the clinical data of patients with hypoparathyroidism and normal function were compared, and the risk factors of hypoparathyroidism after thyroidectomy were analyzed. Result There were 29 cases (19.33%) of hypoparathyroidism in 150 patients after thyroidectomy. Thyroid capsule invasion, lymph node dissection, parathyroid MIS resection, tumor diameter ＞4cm, no nano carbon tracer and open operation were the risk factors of parathyroid dysfunction after thyroidectomy (OR=3.963,3.658,3.281,3.357,3.943,4.187,P ＜ 0.05). Conclusion Patients with hypoparathyroidism after thyroidectomy have a high probability of hypoparathyroidism. The risk factors of hypoparathyroidism include thyroid capsule invasion, lymph node dissection, parathyroid MIS resection, tumor diameter ＞ 4cm, no application of nano carbon tracer and open surgery. According to this, clinical patients can be given targeted treatment and intervention measures after thyroidectomy, to reduce the risk of hypoparathyroidism.

To evaluate the efficacy and safety of endoscopic-assisted small incision thyroidectomy for benign thyroid tumors

QIAN Yezhao

2022, 10(2):  45. 

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Objective To compare the difference between endoscopic-assisted small incision thyroidectomy and traditional open thyroidectomy in the treatment of benign thyroid tumors, and to observe the safety of the operation. Method 70 patients with benign thyroid tumors treated in Kunshan Zongrenqing Memorial Hospital from September 2019 to September 2020 were divided into two groups by different surgical method, 35 cases in each group. Among them, those who received traditional open thyroidectomy were the control group, and those who received endoscopic-assisted small neck incision thyroidectomy were the study group, the operation indexes, treatment time, scar satisfaction, complications, pain degree and recurrence rate were compared under different schemes. Result The operation time in the study group was longer than that in the reference group, but the amount of intraoperative bleeding and postoperative drainage were lower than those in the reference group (P ＜ 0.05).

The time of recovery and discharge in the study group was shorter than that in the reference group, and the patients' 

satisfaction with scar was higher than that in the reference group (P ＜ 0.05), and the incidence of complications was lower than that in the reference group (P ＜ 0.05). There was no significant difference in the degree of pain between the two groups before treatment (P ＞ 0.05), and there was no significant change in the degree of pain in the reference group after treatment (P ＞ 0.05), while the degree of pain in the study group was lower than that before treatment and in the reference group (P ＜ 0.05). There was no significant difference in recurrence rate between the two groups within 1 year (P ＞ 0.05). Conclusion Endoscopic-assisted neck small incision thyroid surgery is better than traditional open thyroid surgery in the treatment of benign thyroid tumors. Although the operation time has increased, it can reduce the amount of bleeding and drainage, reduce the pain of patients, reduce the incidence of complications, and patients are more likely to accept the remaining scars.

Laparoscopic hernia repair and open tension-free hernia repair for the treatment of adult inguinal hernia

LU Xiaodong

2022, 10(2):  49. 

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Objective To investigate the efficacy of laparoscopic hernia repair and open tension-free hernia repair in the treatment of adult inguinal hernia. Method 84 adult patients with inguinal hernia treated in Rugao People's Hospital from April 2016 to April 2021 were randomly divided into control group and observation group. The control group was treated with open tension-free hernia repair, and the observation group was treated with laparoscopic hernia repair. The operation time, bleeding volume and recovery time of the two groups were recorded, the occurrence of complications of the two groups were observed, and the degree of postoperative pain was measured. Result The operation time of the observation group was significantly longer than that of the control group, the amount of intraoperative bleeding was less than that of the control group, and the postoperative pain relief time, postoperative eating time, postoperative out of bed time and hospital stay were significantly shorter than those of the control group (P ＜ 0.05). The incidence of complications in the observation group was 7.14%, which was significantly lower than 26.19% in the control group (P ＜ 0.05). The effective rate of the observation group was 97.62%, which was significantly higher than 83.33% of the control group (P ＜ 0.05). Conclusion Compared with open tension-free hernia repair, laparoscopic hernia repair for adult inguinal hernia can reduce the amount of intraoperative bleeding, accelerate the recovery of gastrointestinal tract, shorten the length of hospital stay, and the postoperative pain subsides rapidly, with fewer complications and high safety.

Effect analysis of painless colonoscopy with titanium clip combined with high-frequency electrocoagulation electrotomy in the treatment of colorectal polyps

ZHAN Liang, CHEN Kunjie

2022, 10(2):  52. 

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Objective To analyze the clinical effect of painless colonoscopy with titanium clip combined with high-frequency electrocoagulation electrotomy in the treatment of colorectal polyps. Method 80 patients with colorectal polyps treated in Dongguan Renkang Hospital from February 2020 to January 2021 were divided into control group (40 cases, treated by painless colonoscopy with high-frequency electrocoagulation) and observation group (40 cases, treated by painless colonoscopy with titanium clip combined with high-frequency electrocoagulation)by different surgical method. The short-term and long-term clinical indexes of the two groups were compared. Result There was no significant difference in operation time between the two groups (P ＞ 0.05). The wound healing time and hospitalization time of the observation group were shorter than those of the control group (P ＜ 0.05); the incidence of perioperative bleeding in the observation group was significantly lower than that in the control group (P ＜ 0.05). There was no significant difference in hemoglobin levels between the two groups at admission and discharge (P ＞ 0.05). The incidence of postoperative complications and recurrence rate 3 months after operation in the observation group were significantly lower than those in the control group (P ＜ 0.05). Conclusion Titanium clip combined with high frequency electrocoagulation and resection under painless enterostomy can achieve good short-term and long-term results in the treatment of colorectal polyps.

The clinical efficacy analysis of interventional therapy in thrombo angitis obliterans

WANG Xiao, KANG Jie

2022, 10(2):  56. 

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Objective To analyze the clinical efficacy of interventional therapy in lower limb thrombo angitis obliterans. Method 100 patients of lower limb thrombo angitis obliterans were treated in the Vascular Surgery of Liaocheng People's Hospital from Jan 2019 to Jun 2021 were selected as the study subjects, they were divided into treatment group (n=50) and control group (n=50)by different treatment methods. Conservative treatment was applied for patients in the control group while interventional treatment was applied for patients in treatment group, clinical efficacy was compared between the two groups. Result After treatment, the blood flow velocity of external iliac artery, ankle brachial index, percutaneous oxygen partial pressure and the diameter of dorsalis pedis artery in the treatment group were significantly improved compared with those before treatment (P ＜ 0.05), and were better than those in the control group. However, in the control group, only blood flow velocity of external iliac artery and ankle brachial index were improved after treatment (P ＜ 0.05), and there was no significant difference in percutaneous oxygen partial pressure and dorsalis pedis artery diameter (P ＞ 0.05). The total effective rate of the treatment group was significantly higher than that of the control group (P ＜ 0.05). Conclusion In the clinical treatment of thrombo angitis obliterans, interventional treatment can significantly improve the patient's condition, improve the efficiency of clinical treatment.

Quantitative CT was used to investigate the correlation between intraperitoneal fat and bone mineral density in obese and overweight patients with different levels of glucose metabolism

YANG Qiushi, XING Qing, LI Xiaoyang, LI Shuo, WANG Yuzhu, YU Wanjiang,

2022, 10(2):  60. 

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Objective To investigate the correlation between abdominal fat and bone mineral density in obese and overweight patients with different levels of glucose metabolism. Method A total of 86 untreated obese and overweight patients with age ≤ 60 years and body mass index (BMI) ≥ 25kg/m2 were selected and divided into normal glucose tolerance group (NGT group, 30 cases), impaired glucose tolerance group (IGT group, 31 cases) and diabetes mellitus group (DM group, 25 cases) according to their glucose metabolism status. Abdominal fat and L1 ～ L3 vertebral bone mineral density (BMD) were measured by quantitative CT. Clinical data related to patients were collected, including patients' age, BMI, total abdominal fat area, visceral fat area, subcutaneous fat area, mean liver fat content, mean pancreas fat content, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, fasting, fasting blood glucose, etc. The correlation between intraperitoneal fat area and bone mineral

density and the difference of bone mineral density among the three groups were analyzed respectively, and the correlation between bone mineral density and various clinical indicators was analyzed. Result There was a negative correlation between intraperitoneal fat area and bone mineral density in NGT group, IGT group and DM group (all P ＜ 0.05), and the correlation between intraperitoneal fat area and bone mineral density in NGT group was higher (r=-0.525, P ＜ 0.05). BMD of NGT group and IGT group was higher than that of DM group, respectively, with statistical significance (P ＜ 0.05). There was no significant difference in bone mineral density between the NGT group and the IGT group (P ＞ 0.05). The results of multivariate regression analysis showed that the intraperitoneal fat area was influence factor of bone mineral density (P ＜ 0.05). Conclusion Intraperitoneal fat area was negatively correlated with bone mineral density in both obese and overweight people regardless of abnormal glucose metabolism. The relationship between abdominal fat and BMD is complex, and abdominal fat may be a factor affecting bone mineral density in obese patients.

Clinical diagnosis and treatment analysis of appendix mucinous cystadenoma

GUO Hongrong, LI Xuejun, HOU Yuefeng

2022, 10(2):  65. 

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Objective Improve the cognition and clinical diagnosis and treatment level of appendix mucinous cystadenoma. Method Clinical data of 17 misdiagnosed appendix mucinous cystadenoma from February 2005 to June 2020 in Central Theater Command Air Force Hospital were retrospectively analyzed, including clinical manifestations and treatment, the diagnosis and treatment of mucinous cystadenoma of appendix were summarized. Result Not clinically specific in 17 patients.5 cases were misdiagnosed as ovarian cysts;7 cases were misdiagnosed as appendix abscess;3 cases were misdiagnosed as ileocecal tumor;1 case was misdiagnosed as abdominal tuberculosis;1 case was misdiagnosed as a right ureteral tumor. All of the 17 cases were treated surgically, postoperative pathology was confirmed as appendix mucinous cystadenoma.14 cases were followed up for10

months to 12 years. Recurrence and metastasis were found in 2 cases, and one of them died. Conclusion Appendix mucinous cystadenoma has no characteristic clinical manifestations, the misdiagnosis rate is high, Delaying the diagnosis and treatment can have serious consequences. Early diagnosis and the correct surgical method are the key to the treatment of the disease.

Effect of nutritional support after distal subtotal gastrectomy combined with Roux-en-Y anastomosis in patients with gastric cancer

WANG Jiahui

2022, 10(2):  69. 

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Objective To observe the value of nutritional support therapy after distal subtotal gastrectomy combined with Roux-en-Y anastomosis in patients with gastric cancer. Method 50 patients with gastric cancer treated in Nanjing Gaochun People's Hospital from February 2020 to October 2021 were divided into 25 cases in the control group (postoperative parenteral nutrition support treatment) and 25 cases in the experimental group (enteral nutrition support treatment)by different nutritional treatments. The indexes of the two groups were compared and analyzed. Result The first postoperative exhaust time, first defecation time, hospital stay and gastrointestinal recovery time in the experimental group were shorter than those in the control group (P ＜ 0.05). Before the intervention, there was no significant difference in the levels of serum prealbumin, plasma albumin and total protein between the two groups (P ＞ 0.05);after the intervention, the levels of serum prealbumin, plasma albumin and total

protein in the experimental group were significantly higher than those in the control group (P ＜ 0.05). On the first day after operation, there was no significant difference in the levels of IgA, IgG and IgM between the two groups (P ＞ 0.05); the levels of IgA, IgG and IgM in the experimental group were significantly higher than those in the control group on the seventh day after operation (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion The effect of enteral nutrition support is better in the postoperative nutritional support treatment of patients with gastric cancer, which can significantly improve the nutritional and immune indexes of patients.

Effect of sequential enteral and parenteral nutrition on nutrition and prognosis of elderly cancer patients in intensive care unit

ZHAO Jinfeng

2022, 10(2):  73. 

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Objective To analyze the effect of sequential enteral and parenteral nutrition on nutrition and prognosis of elderly cancer patients in intensive care unit. Method 92 elderly cancer patients admitted to the intensive care unit of Yunnan Cancer Hospital from March 2020 to May 2021 were randomly divided into two groups with 46 cases in each group by different nutritional treatment methods. The control group was given parenteral nutrition support, and the observation group was given enteral and parenteral nutrition support in sequence. The changes of nutritional indexes, immune indexes, hospitalization and complications before and after intervention were compared between the two groups. Result There was no significant difference in the levels of serum protein, prealbumin and hemoglobin between the two groups before intervention (P ＞ 0.05). After intervention, the levels of serum protein, prealbumin and hemoglobin in the observation group were higher than those in the control group (P ＜ 0.05). There was no significant difference in the levels of IgG and IgM between the two groups before intervention (P ＞ 0.05). After intervention, the levels of IgG and IgM in the observation group were higher than those in the control group (P ＜ 0.05). The ventilator time and hospital stay in the observation group were shorter than those in the control group (P ＜ 0.05), and the incidence of complications was 13.0%, lower than 37.0% in the control group (P ＜ 0.05). Conclusion Sequential enteral and parenteral nutrition can improve the nutritional status of elderly cancer patients in intensive care unit, improve their immune ability, shorten the length of hospital stay, reduce the incidence of complications and promote rehabilitation. It is of great significance to improve their prognosis.

Effect of acupoint massage combined with reverse order movement to restore bowel function

MA Xiaoyan, LI Chang, XING Jianwei, JI Yanyan, MA Lei, YANG Lu, ZHANG Dianliang

2022, 10(2):  77. 

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Objective To observe the effect of acupoint massage combined with reverse motion combined with the concept of enhanced recovery after surgery(ERAS) on the recovery of intestinal function in postoperative patients with rectal cancer. Method A total of 114 patients with rectal cancer who underwent surgical treatment in Qingdao Municipal Hospital from August 2020 to May 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, 57 cases of each group. The control group received conventional nursing measures, and the observation group received a set of acupoint massage combined with reverse movement nursing measures developed under ERAS concept, the first exhaust, defecation time, bowel sound recovery time, hospital stay and intestinal recovery were compared between the two groups. Result The time of first exhaust, defecation and bowel sound recovery in the observation group were significantly

earlier than those in the control group, the length of hospitalization in the observation group was shorter than that in the control group, and the functional dyspepsia symptom score in the observation group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Acupoint massage combined with reverse motion combined with the concept of accelerated rehabilitation surgery can effectively promote the recovery of intestinal function in postoperative patients with rectal cancer. 

Application effect of five element music therapy combined with 6 minute walking test in perioperative accelerated rehabilitation surgical nursing of rectal cancer patients #br#

CHEN Chuxia

2022, 10(2):  81. 

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Objective To explore the effect of five element music therapy combined with 6 minute walking test (6MWT) in perioperative accelerated rehabilitation surgery nursing of rectal cancer patients. Method From June 2019 to January 2021, 90 patients with rectal cancer who needed radical resection of rectal cancer in Huazhong University of Science and Technology Union Shenzhen Hospital were selected as the research objects. They were numbered according to the order of admission and divided into experimental group and control group according to the random number table, with 45 cases in each group. The control group received routine perioperative accelerated rehabilitation surgical nursing, while the experimental group received five element music therapy combined with 6MWT. The effect of 6MWT before and after intervention, postoperative eating time, exhaust

time, length of hospital stay and postoperative complications were compared between the two groups. Result There was no significant difference between the two groups before the intervention (P ＞ 0.05). The 6MWT result after the intervention in the experimental group was (375.07 ± 21.95) m, which was significantly higher than that before the intervention (228.66 ± 15.69) m, and also higher than that in the control group (P ＜ 0.05). The postoperative eating time, exhaust time and hospital stay in the experimental group were shorter than those in the control group, and the incidence of postoperative complications was also lower than that in the control group (P ＜ 0.05). Conclusion Five element music therapy combined with 6MWT nursing can accelerate the postoperative rehabilitation of patients with rectal cancer, reduce postoperative complications and improve the postoperative clinical outcome.

Effect of Xiaoyao Loubei decoction combined with emotional therapy of traditional chinese medicine on breast hyperplasia

LUO Jie

2022, 10(2):  84. 

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Objective To explore and analyze the effect of Xiaoyao Loubei Decoction combined with emotional therapy of traditional chinese medicine on hyperplasia of mammary glands. Method A total of 126 patients with hyperplasia of mammary glands admitted to Xingbin District People's Hospital of Laibin from June 2018 to June 2020 were selected as the research objects, and randomly divided into the control group and the observation group, with 63 cases in each group. The control group was treated with Xiaoyao Loubei Decoction; The observation group was treated with emotional therapy of traditional chinese medicine on the basis of the control group, and the treatment effect, sex hormone levels and symptoms and signs scores before and after treatment were compared between the two groups. Result The effective rate of treatment in the observation group was significantly higher than that in the control group (P ＜ 0.05). After 3 months of treatment, the serum progesterone levels in both groups increased, while the serum estradiol and prolactin levels decreased. After treatment, the serum progesterone

levels in the observation group were significantly higher than those in the control group (P ＜ 0.05), and the serum estradiol and prolactin levels were significantly lower than those in the control group (P ＜ 0.05). After 3 months of treatment, the scores of symptoms and signs in both groups decreased, and the observation group was significantly lower than the control group (P ＜ 0.05). Conclusion Xiaoyao Loubei Decoction combined with emotional therapy of traditional chinese medicine can effectively improve the treatment efficiency of patients with hyperplasia of mammary glands, reduce the level of sex hormones and symptoms of patients.

Study on the improvement of tumor marker levels in patients with breast cancer treated with cetaxel combined with pirarubicin chemotherapy

ZHANG Yanmin

2022, 10(2):  87. 

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Objective To study the improvement of tumor marker levels in patients with breast cancer treated with docetaxel combined with pirarubicin chemotherapy. Method A total of 72 breast cancer patients who were treated in Liangshan County People's Hospital in Jining City from January 2019 to December 2019 were included in this study. They were divided into groups according to the coin toss method. The control group (typeface)of 36 patients received paclitaxel combined with pirarubicin. 36 cases in the observation group (flower face) were treated with docetaxel combined with pirarubicin. The tumor marker levels, toxic and side effects, disease control, 1-year survival rate and recurrence rate were compared between the two groups. Result After chemotherapy, the levels of CEA, CA125, CA153 and the 1-year recurrence rate in the observation group were lower than those in the control group, and the disease control rate was higher than that in the control group, and the difference was statistically

significant (P ＜ 0.05). There was no significant difference between the incidence rate and the 1-year survival rate (P ＞ 0.05). Conclusion Cetaxel combined with pirarubicin chemotherapy for breast cancer patients has an ideal effect, which can improve the level of tumor markers, and does not increase the incidence of adverse drug reactions and recurrence.

Effect of rocuronium combined with cisatracurium on muscle relaxation in patients undergoing laparoscopic cholecystectomy

PAN Yanping

2022, 10(2):  91. 

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Objective To study the muscle relaxation effect of rocuronium combined with cisatracurium in laparoscopic cholecystectomy. Method 60 patients who underwent laparoscopic cholecystectomy in Liyang People's Hospital from June 2019 to June 2021 were included in the study. They were randomly divided into two groups with 30 cases in each group. Anesthesia group 1: rocuronium anesthesia. Anesthesia group 2: rocuronium combined with cisatracurium atracurium anesthesia. The heart rate, mean arterial pressure, the onset time of muscle relaxation, the maintenance time of muscle relaxation effect, the time of recovery room, the number of additional muscle relaxation drugs during operation and the time of extubation after operation were compared between the two groups. Result There was no significant difference in heart rate and mean arterial pressure between the two groups before anesthesia induction, 1 min after anesthesia induction and 5 min after anesthesia induction (P ＞0.05); In anesthesia group 2, the onset time of muscle relaxation was (105.58 ± 1.15) s, the maintenance time of muscle relaxation was (51.38 ± 3.23) min, the time of recovery room was (32.58 ± 8.15) min, and the time of extubation after operation was (11.52 ± 3.09) min, which was lower than (112.34 ± 2.47) s, (40.41 ± 3.14) min, (43.34 ± 8.47) min and (17.49 ± 3.12) min in anesthesia group 1 (P ＜ 0.05); The number of additional muscle relaxants in the anesthesia group 2 was (1.01 ± 0.05), which was less than that in the anesthesia group 1 (1.88 ± 0.13) (P ＜ 0.05). Conclusion Rocuronium combined with cisatracurium atracurium anesthesia in laparoscopic cholecystectomy has a good muscle relaxation effect, and has no significant effect on hemodynamics.

The application of case nursing combined with psychological nursing in microwave ablation of thyroid gland disease and its influence on pain perception negative emotion and compliance behavior

HUANG Mei

2022, 10(2):  94. 

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Objective To investigate the application of case nursing combined with psychological care in microwave ablation of thyroid gland disease and its effect on pain perception, negative emotion and compliance behavior. Method A total of 114 patients with thyroid disease admitted to Huanggang Central Hospital from January 2020 to January 2021 were selected and divided into two groups according to different nursing method, including 57 cases in the observation group and 57 cases in the control group. Both groups received microwave ablation treatment. The control group only received routine perioperative intervention, and the observation group received individual nursing combined with psychological care. The changes of pain perception, negative emotion and compliance behavior before and after intervention were compared between the two groups. Result Before

intervention, there were no significant differences in pain perception, negative emotion and compliance between the two groups (P ＞ 0.05). After intervention, the pain score, self-rating anxiety scale score, self-rating depression scale score and compliance of the observation group were significantly better than those of the control group, with statistically significant differences (P ＜ 0.05). Conclusion Individual nursing combined with psychological nursing intervention microwave ablation for thyroid patients has a good effect.

Application effect of evidence-based nursing in pipeline nursing in gastrointestinal surgery

CHEN Jiaqin

2022, 10(2):  98. 

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Objective To explore the application effect of evidence-based nursing in pipeline nursing in gastrointestinal surgery. Method 178 patients admitted in our hospital from January 2019 to October 2021 were divided into control group and observation group by different nursing methods, 89 cases in each group. The control group with routine nursing mode, the observation group with evidence-based nursing model, The incidence of unplanned extubating, nursing effect, degree of pain, quality of life and bad mood were compared between the two groups before and after nursing. Result The nursing quality, nursing effect and quality of life in the observation group were higher than those in the control group (P ＜ 0.05). The degree of pain and bad mood in the observation group were lower than those in the control group (P ＜ 0.05). Conclusion evidence-based nursing model, can

effectively reduce the incidence of unplanned extubating, improve quality of life, relieve pain, reduce bad mood In

gastrointestinal surgery patients,, nursing effect is significant.

Influence of perioperative nursing on nursing quality of patients with gastric cancer radical surgery

KAN Chunyan

2022, 10(2):  102. 

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Objective To investigate the effect of perioperative nursing intervention in patients undergoing radical gastrectomy for gastric cancer and its impact on nursing quality. Method A total of 42 patients with gastric cancer who underwent radical surgery in our hospital from May 2020 to May 2021 were selected for research, and they were divided into groups according to different nursing methods, namely the control group (implementing routine nursing intervention) and the observation group (implementing routine nursing intervention). Perioperative nursing intervention), 21 cases in each group, the levels of gastrointestinal hormones, nutritional indicators and nursing quality scores before and after nursing in the two groups were analyzed. Result After nursing, the motilin and serum ghrelin of the observation group were (189.22±22.63) ng/L and (61.58±5.73) ng/L, respectively,which were higher than those of the control group (168.53±21.42) ng/L and (46.27±5.88) ng/L, and vasoactive intestinal peptide of the observation group was (62.35±7.07) ng/L, which was lower than that of the control group (83.18±7.14) ng/L, and the difference was significant (P ＜ 0.05). The albumin of the control group and the observation group after nursing were (36.25±3.49) g/L, (42.77±4.96) g/L, retinol binding protein were (29.97±3.02) mg/L, (36.65±3.28) mg/L, hemoglobin were (87.13±5.56) g/L, (97.32±5.71) g/L, the latter was significantly higher than the former (P ＜ 0.05); the scores of nursing methods, nursing attitudes, nursing skills and nursing environment of the observation group were (74.13±6.48) points, (71.02±5.95) points, (68.22±6.34) points and (72.13±6.34) points, respectively, which were significantly higher than those of the control group (56.23±5.47) points, (48.23±5.29) points, (51.17±4.57) points and (57.15±4.92) points (P ＜ 0.05). Conclusion Perioperative nursing plays an important role in gastric cancer patients undergoing radical operation, which can improve their nutritional status and gastrointestinal function, and the overall nursing quality is high.

Effect analysis of comprehensive nursing model applied to patients with endoscopic gastrointestinal polypectomy

ZHAO Yanzhen, LIANG Xueyan, WU Shanhong

2022, 10(2):  106. 

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Objective To explore the effect of comprehensive nursing model in patients with endoscopic gastrointestinal polypectomy. Method 84 patients with gastrointestinal polyps treated in Zhanjiang First Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected as the research object. They were divided into experimental group and control group by different nursing methods, with 42 cases in each group. The control group was treated with routine nursing mode, and the experimental group was treated with comprehensive nursing mode on the basis of the control group. The treatment effect, psychological state and postoperative complications of the two groups were compared. Result After nursing, the cure rate of the experimental group was higher than that of the control group, but there was no significant difference (P ＞ 0.05); the hospitalization time was significantly shorter than that in the control group (P ＜ 0.05); the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the experimental group were lower than those in the control group, and the incidence of postoperative complications was significantly lower than that in the control group (P ＜ 0.05). Conclusion The application of comprehensive nursing model in patients with endoscopic polypectomy is effective, which can effectively reduce the length of hospital stay, improve the negative psychological state of patients, and reduce the incidence of postoperative adverse reactions. 

Clinical effect of holistic nursing intervention in operating room during laparoscopic resection of primary liver cancer

ZHANG Chengyan

2022, 10(2):  111. 

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Objective To study the effect of holistic nursing intervention in the operating room during laparoscopic resection of primary liver cancer. Method 60 patients with primary liver cancer treated by laparoscopic resection in Shiyan Yunyang Traditional Chinese Medicine Hospital from August 2019 to August 2021 were divided into experimental group and control group by different nursing methods, with 30 cases in each group. The control group was treated with routine operating room nursing, and the experimental group was treated with integrated operating room nursing. The operation time and bleeding volume, postoperative recovery related indexes, incidence of complications and nursing satisfaction were compared between the two groups. Result The operation time and bleeding volume in the experimental group were less than those in the control group; the postoperative

recovery related indexes were better than those in the control group; the total incidence of complications in the experimental group (3.33%) was significantly lower than that in the control group (26.67%); the nursing satisfaction of the experimental group (96.67%) was significantly higher than that of the control group (76.67%),all differences were significant（P ＜ 0.05）. Conclusion During the operation of patients with primary liver cancer, the implementation of integrated nursing in the operating room has a good effect, which can significantly reduce the incidence of complications, shorten the clinical recovery time of patients and improve nursing satisfaction.

Application of postoperative nursing measures in patients with pancreatic cancer and type 2 diabetes mellitus

HUANG Zhaohua

2022, 10(2):  115. 

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Objective To analyze the effect of postoperative nursing measures on patients with pancreatic cancer complicated with type 2 diabetes. Method From July 2019 to November 2021, 43 patients with pancreatic cancer and type 2 diabetes mellitus in Nanjing Gaochun People's Hospital were selected and divided into control group (n=22) and observation group (n=21)by different nursing methods. The control group was given routine nursing, and the observation group was given postoperative nursing measures. The wound healing time, postoperative hospital stay, complication rate and quality of life were compared between the two groups. Result After nursing, the wound healing time and postoperative hospital stay in the observation group were lower than those in the control group (P ＜ 0.05). After nursing, the total incidence of infection, hypoglycemia and lower extremity deep venous thrombosis in the observation group was 4.76%, which was lower than 27.27% in the control group (P ＜ 0.05). After nursing, the scores of physical function, psychological function, material function and social function in the observation group were higher than those in the control group (P ＜ 0.05). Conclusion Appropriate nursing intervention for patients with pancreatic cancer and type 2 diabetes can improve the healing time of incision, reduce the incidence of complications, promote early recovery and discharge of patients, and improve the quality of life of patients.