Abstract:

Objective To study the muscle relaxation effect of rocuronium combined with cisatracurium in laparoscopic cholecystectomy. Method 60 patients who underwent laparoscopic cholecystectomy in Liyang People's Hospital from June 2019 to June 2021 were included in the study. They were randomly divided into two groups with 30 cases in each group. Anesthesia group 1: rocuronium anesthesia. Anesthesia group 2: rocuronium combined with cisatracurium atracurium anesthesia. The heart rate, mean arterial pressure, the onset time of muscle relaxation, the maintenance time of muscle relaxation effect, the time of recovery room, the number of additional muscle relaxation drugs during operation and the time of extubation after operation were compared between the two groups. Result There was no significant difference in heart rate and mean arterial pressure between the two groups before anesthesia induction, 1 min after anesthesia induction and 5 min after anesthesia induction (P ＞0.05); In anesthesia group 2, the onset time of muscle relaxation was (105.58 ± 1.15) s, the maintenance time of muscle relaxation was (51.38 ± 3.23) min, the time of recovery room was (32.58 ± 8.15) min, and the time of extubation after operation was (11.52 ± 3.09) min, which was lower than (112.34 ± 2.47) s, (40.41 ± 3.14) min, (43.34 ± 8.47) min and (17.49 ± 3.12) min in anesthesia group 1 (P ＜ 0.05); The number of additional muscle relaxants in the anesthesia group 2 was (1.01 ± 0.05), which was less than that in the anesthesia group 1 (1.88 ± 0.13) (P ＜ 0.05). Conclusion Rocuronium combined with cisatracurium atracurium anesthesia in laparoscopic cholecystectomy has a good muscle relaxation effect, and has no significant effect on hemodynamics.

Key words: Laparoscopic cholecystectomy, Rocuronium, Cisatracurium, Anesthesia, Muscle relaxation effect, Hemodynamics