Abstract:

Objective To investigate the correlation between abdominal fat and bone mineral density in obese and overweight patients with different levels of glucose metabolism. Method A total of 86 untreated obese and overweight patients with age ≤ 60 years and body mass index (BMI) ≥ 25kg/m2 were selected and divided into normal glucose tolerance group (NGT group, 30 cases), impaired glucose tolerance group (IGT group, 31 cases) and diabetes mellitus group (DM group, 25 cases) according to their glucose metabolism status. Abdominal fat and L1 ～ L3 vertebral bone mineral density (BMD) were measured by quantitative CT. Clinical data related to patients were collected, including patients' age, BMI, total abdominal fat area, visceral fat area, subcutaneous fat area, mean liver fat content, mean pancreas fat content, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, fasting, fasting blood glucose, etc. The correlation between intraperitoneal fat area and bone mineral

density and the difference of bone mineral density among the three groups were analyzed respectively, and the correlation between bone mineral density and various clinical indicators was analyzed. Result There was a negative correlation between intraperitoneal fat area and bone mineral density in NGT group, IGT group and DM group (all P ＜ 0.05), and the correlation between intraperitoneal fat area and bone mineral density in NGT group was higher (r=-0.525, P ＜ 0.05). BMD of NGT group and IGT group was higher than that of DM group, respectively, with statistical significance (P ＜ 0.05). There was no significant difference in bone mineral density between the NGT group and the IGT group (P ＞ 0.05). The results of multivariate regression analysis showed that the intraperitoneal fat area was influence factor of bone mineral density (P ＜ 0.05). Conclusion Intraperitoneal fat area was negatively correlated with bone mineral density in both obese and overweight people regardless of abnormal glucose metabolism. The relationship between abdominal fat and BMD is complex, and abdominal fat may be a factor affecting bone mineral density in obese patients.

Key words: Type 2 diabetes mellitus,, Intraperitoneal fat, Bone mineral density, Glucose metabolism, Quantitative computed tomography