Table of Content

01 January 2022, Volume 10 Issue 1

Previous Issue   

Application value of fine capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve in total thyroidectomy for patients with thyroid cancer

JIN Xiongwei, LI Hongshuai, YANG Zuohao, LI Manzhi, ZHANG Hao

2022, 10(1):  2. 

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Objective To explore the application value of fine capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve in total thyroidectomy for thyroid cancer patients. Method 90 patients with thyroid cancer in Dongguan Kanghua Hospital from January 2018 to September 2020 were selected. They were randomly divided into two groups, with 45 cases in each group. The control group was treated with conventional total thyroidectomy and inferior thyroid artery exposure of recurrent laryngeal nerve, while the observation group was treated with refined capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve. The operation conditions, changes of thyroid function indexes before and after operation, postoperative complications and recurrence after 6 months of follow-up were compared between the two groups. Result There was no significant difference in the operation time, intraoperative blood loss and the number of lymph node dissection between the two groups (P ＞ 0.05); The detection results of serum parathyroid hormone and Ca2+ in the observation group on 1 day and 3 days after operation were higher than those in the control group, and the difference was significant(P ＜ 0.05); The incidence of recurrent laryngeal nerve injury, hypoparathyroidism and hypocalcemia in the observation group were lower than those in the control group, the difference between the data was significant (P ＜ 0.05); there was no significant difference in the recurrence rate of the two groups after 6 months of follow-up (P ＞ 0.05). Conclusion In total thyroidectomy for patients with thyroid cancer, fine capsule anatomy combined with exposure of recurrent laryngeal nerve in cricothyroid space is beneficial to protect the function of recurrent laryngeal nerve and parathyroid gland.

Application effect of selective cervical lymph node dissection in radical thyroidectomy

YUAN Junhua, WANG Jun

2022, 10(1):  7. 

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Objective To study the effect of selective cervical lymph node dissection during radical thyroidectomy. Method A total of 50 patients with thyroid cancer who were admitted to the Red Star Hospital of the 13th Division of Xinjiang Production and Construction Corps from August 2019 to August 2021 were selected and divided into the control group and the research group according to the random number table method, 25 cases in each group. The control group received radical thyroidectomy. Radical thyroid cancer surgery + selective cervical lymph node dissection was used in the research group, and the cervical lymph node metastasis and complications were compared between the two groups. Result The rate of cervical lymph node metastasis in the study group (16.00%) was lower than that in the control group (44.00%), and the difference was significant (χ2=4.667, P=0.031). The incidence of complications in the study group (8.00%) was lower than that in the control group. group (12.00%), the difference was not significant (χ2=0.222, P=0.637). Conclusion Selective cervical lymph node dissection in radical thyroidectomy can reduce postoperative lymph node metastasis and reduce the risk of complications.

Curative effect of polypectomy under painless gastroenteroscopy in the treatment of intestinal polyps

TANG Shuijin, XU Xirong

2022, 10(1):  11. 

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Objective To investigate the clinical practice of endoscopic polypectomy in patients with intestinal polyps, and to evaluate its clinical efficacy. Method 80 patients with intestinal polyp in the Second Affiliated Hospital of Nantong University were enrolled in this study, and the corresponding time was 2021. According to the study requirements, all patients were divided into two groups at a ratio of 1 ∶ 1, each group of patients used different treatment methods, specifically involving two types of laparoscopic polypectomy, gastrointestinal polypectomy, comparative Analysis was carried out in the form of control group and observation group. Result The operation time, first exhaust time and hospital stay in the observation group were shorter than those in the control group, and the amount of intraoperative bleeding, surgical removal rate and complication rate were better than those in the control group (P ＜ 0.05). Conclusion From the safety and effectiveness of intestinal polyp surgery, gastrointestinal polypectomy is more valuable than laparoscopic polypectomy.

Comparative study on clinical efficacy of laparoscopic appendectomy and open appendectomy in the treatment of acute appendicitis

ZHANG Yu

2022, 10(1):  15. 

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Objective To compare the clinical effects of laparoscopic appendectomy(LA) and open appendectomy(OA). Method 71 patients undergoing appendectomy in general surgery of Qingyang Hospital of Jiangyin City were selected, they were divided into LA Group (37 cases received LA) and OA group(34 cases received OA). The operation, pain and postoperative complications of the two groups were compared. Result There was no significant difference in the operation time and the first postoperative exhaust time between La group and OA group (P ＞ 0.05); the length of stay in LA group was significantly lower than that in OA group (P ＜ 0.05), but the hospitalization cost in OA group was significantly lower than that in LA group (P ＜ 0.05). The visual analogue scale (VAS) scores at 30 min, 12h and 24h after operation in LA group were lower than those in OA group (P ＜ 0.05), and the total incidence of complications (5.0%) was significantly lower than that in OA group (18.92%). Conclusion

LA can accelerate the rehabilitation of patients with acute appendicitis, reduce postoperative pain and reduce the risk of postoperative complications, but the cost is higher than that of traditional open surgery. 

Effect and complication rate impact evaluation of sphincter preserving hanging wire method in complex anal fistulas

YE Yan

2022, 10(1):  19. 

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Objective To investigate the effects of the application of sphincter preserving hanging wire method in patients with complex anal fistulas. Method A total of 120 patients with complicated anal fistula who were admitted to Guangzhou Zengcheng District Central Hospital from March 2019 to March 2021 were randomly selected as the study subjects and divided into control and observation groups using the number table method, with 60 patients in each group. The control group was treated by conventional fistula resection, and the observation group was treated by sphincter preserving hanging wire method. Treatment outcomes, intraoperative conditions, as well as postoperative complication rates were compared between the 2 groups. Result patients in the observation group had a higher response rate to treatment than those in the control group (P ＜ 0.05), patients in the observation group had less intraoperative blood loss and a shorter operative time than the control group (P ＜ 0.05), and patients in the observation group had a lower rate of postoperative complications than those in the control group (P＜ 0.05). Conclusion The application of sphincter preserving hanging wire method in the treatment of patients with complex anal fistulas is highly effective, which may promote patient recovery and reduce the occurrence of postoperative complications.

Clinical analysis of Polidocanol combined with Coil embolization in the treatment of varicocele

WANG Peng, WANG Kai, ZHAO Kai, LI Mingxin, JIAN Zhaocheng, ZHANG Guoqing, CHEN Junliang, SUN Shunji

2022, 10(1):  22. 

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Objective To analyze the clinical effect of Polidocanol combined with Coil embolization in the treatment of varicocele. Method 28 cases of varicocele in Affiliated Hospital of Weifang Medical University from February 2017 to February 2020 were treated with Polidocanol combined with coil embolization. Venous reflux and semen quality improvement were observed before and after operation, and all patients were follow-up for 12 months. The efficacy of embolization therapy were evaluate. Result All 28 patients with varicocele were embolized. After operation, the reverse flow degree of spermatic vein was reduced or disappeared. The average semen volume before operation was (2.54±0.33)ml, which increased to(3.18±0.21)ml and (3.42±0.18)ml at 6 and 12 months after operation, respectively. The average sperm density before operation was (21.55±3.74)×106/ml, increased to (31.46±4.02)×106/ml and (34.69±3.77)×106/ml at 6 and 12 months after operation. The average sperm motility rate before operation was (46.31±4.95)%, 6 and 12 months after operation, which increased to (56.47±5.07)% and 

(59.19±5.17)%, respectively. Conclusion Polidocanol combined with Coil embolization in the treatment of Varicocele is effective.

Clinical comparison of high ligation combined with dot and traditional stripping in patients with varicose great saphenous vein

WANG Zhiyong

2022, 10(1):  26. 

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Objective To investigate the clinical effect of high ligation combined with dot and traditional stripping in patients with varicose great saphenous vein. Method 80 subjects were selected from patients with great saphenous varices treated in Xiji Health Center of Tongzhou District in Beijing from September 2018 to July 2021. They were randomly divided into control group and observation group, with 40 cases in each group. The patients in the control group were treated with high ligation of great saphenous vein combined with traditional stripping, and the patients in the observation group were treated with high ligation of great saphenous vein combined with dot stripping. The patients in both groups were followed up to discharge. The hospital stay, operation time, out of bed activity time, intraoperative blood loss and the levels of serum tumor necrosis factor-a, interleukin-6 and nitric oxide before and 3 days after operation were compared between the two groups, the Visual analogue scale (VAS), venous clinical severity score (VCSS), and chronic venous insufficiency questionnaire (CIVIQ) were also compared between the two groups. Result The hospitalization time and operation time of the observation group were shorter than those of the control group, the activity time of getting out of bed was earlier than that of the control group, and the amount of intraoperative bleeding was less than that of the control group (all P ＜ 0.05). Compared with before operation, the levels of serum tumor necrosis factor-a, interleukin-6 and nitric oxide in the two groups increased three days after operation, but the increase range of patients in the observation group was lower than that in the control group (P ＜ 0.05). Compared with before operation, the VAS and VCSS scores of the two groups decreased and CIVIQ scores increased 7 days after operation, and the decrease range of VAS and VCSS scores in the observation group was better than that in the control group(P ＜ 0.05), CIVIQ score increased significantly better than the control group(P ＜ 0.05). Conclusion Compared with traditional stripping, high ligation combined with dot stripping can effectively shorten the time of getting out of bed, operation and hospitalization, reduce intraoperative blood loss, reduce pain and stress reaction, and improve the quality of life of patients with great saphenous vein varicose.

Clinical efficacy analysis of recurrent laryngeal nerve exposure in unilateral thyroid surgery with or without intraoperative neural monitoring

YE Jian, TAN Jianhui, HUANG Yongsheng

2022, 10(1):  32. 

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Objective To analyze the clinical effect of recurrent laryngeal nerve (RLN) exposure in unilateral thyroid surgery with or without intraoperative neural monitoring(IONM).Method The clinical data of 66 patients who received the unilateral thyroid surgery in Shunde Hospital of Southern Medical University from January 2019 to November 2020 were retrospectively reviewed and analyzed. The application of IONM served as the categorization basis of two groups, with 33 cases in each group. In the group without nerve monitoring, the recurrent laryngeal nerve was directly exposed by blunt dissection, while in the group with IONM, the RLN was gradually exposed under the guidance of IONM. Then the amount of bleeding, the incidence of RLN injury, the length of stay and medical expenses of the two groups were compared and analyzed. Result There was no significant difference in the amount of bleeding and length of stay between the two groups (P ＞ 0.05). The rate of temporary RLN injury in the group with IONM was lower than that in another group without IONM, but there was no significant difference (P ＞ 0.05). The medical expenses in the group with IONM were significantly higher than that in another group without IONM (P ＜ 0.05). Conclusion Whether the intraoperative neural monitoring is adopted or not, the operation safety and efficacy in the unilateral thyroid surgery is consistent in exposing the recurrent laryngeal nerve. However, the application of nerve monitoring entails a higher cost but helps to reduce the incidence of RLN injury to a certain extent. 

Risk factors of neonate with congenital megacolon

HAN Xiao, TAO Yue, GUO Wanliang, HUANG Shungen, SHI Sanli

2022, 10(1):  36. 

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Objective To evaluate the predictive value of barium enema in the diagnosis of congenital megacolon. Method The clinical data of 107 infants admitted to the Children’s Hospital of Suzhou University from July 2015 to December 2019 were analyzed retrospectively, the patients were divided into case group and control group according to pathological results. The results were compared between case group and control group.Receiver operator characteristic curve ROC curve, analysis was used to determine the diagnostic ability of the relevant factors. Result Among the 107 children, 51 cases of congenital megacolon(case group) were diagnosed (41 males and 10 females). In univariate analysis, the results of vomiting, abdominal distention, delayed meconium excretion, barium enema and digital rectal examination were significantly compared between the two groups. Multivariate regression analysis showed that the results of barium enema (95%CI 11.718 ～ 999.99) were independent factors affecting congenital megacolon. The area under the ROC curve of barium enema in the diagnosis of neonatal congenital megacolon was 0.949, the diagnostic sensitivity was 92.2%, and the specificity was 94.6%. Conclusion Abdominal distension, vomiting, no meconium excretion in 24 hours, gas in intestinal cavity and bursting sensation after digital rectal examination are relevant factors in the diagnosis of congenita megacolon, and barium enema is an independent factor in the diagnosis of neonatal congenital megacolon. 

Effects of dexmedetomidine on postoperative sleep quality and psychological status in patients undergoing laparoscopic gastrointestinal tumor surgery

KONG Weiyuan, FU Qi, GUO Zhongwu, ZHANG Qi, YIN Xiang

2022, 10(1):  41. 

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Objective To analyze the effect of dexmedetomidine on postoperative mental state and sleep quality in patients with gastrointestinal tumors undergoing laparoscopic surgery. Method 60 patients with gastrointestinal tumors treated in Daqing Oilfield General Hospital from January 2020 to January 2021 were randomly divided into study group and control group. Before anesthesia induction, dexmedetomidine was injected by pump in the study group and normal saline was injected by pump in

the control group. The snack rate, mean arterial pressure, self-rating depression scale (SDS), self-rating anxiety scale (SAS) and Athens insomnia scale (AIS) were compared between the two groups. Result Compared with the control group, the heart rate and mean arterial pressure in the study group were lower at T1 ～ 4 (P ＜ 0.05), the SDS and SAS scores were lower at 3 days after operation (P ＜ 0.05), and the AIS scores were lower at 1 and 3 days after operation (P ＜ 0.05). Conclusion Dexmedetomidine is effective in laparoscopic surgery for gastrointestinal tumors. It can not only alleviate depression, anxiety and other adverse psychology, maintain the stability of vital signs, but also improve the quality of sleep.

Anesthetic effect of remifentanil combined with propofol in laparoscopic cholecystectomy

SUN Rui

2022, 10(1):  45. 

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Objective To investigate the anesthetic effect of remifentanil combined with propofol in laparoscopic cholecystectomy. Method 88 patients who underwent laparoscopic cholecystectomy in Liyang branch of Jiangsu Provincial People's Hospital from July 2020 to July 2021 were selected, they were randomly divided into control group (44 cases, anesthesia with propofol) and observation group (44 cases, anesthesia with remifentanil combined with propofol). The anesthesia recovery effect, adverse

reactions, systolic blood pressure, diastolic blood pressure, heart rate level before and after operation and the score of Mini Mental State Examination (MMSE) were compared between the two groups. Result Compared with the control group, the recovery of orientation, consciousness, extubation and spontaneous breathing in the observation group were shorter, The visual analogue score was lower (P ＜ 0.05). After operation, the levels of systolic blood pressure, diastolic blood pressure and heart rate in the observation group were better than those in the control group (P ＜ 0.05). At 1h and 24h after extubating, the MMSE score in the observation group was higher than that in the control group (P ＜ 0.05). Compared with the incidence of adverse reactions in the control group (13.64%), the incidence of complications in the observation group (2.27%) was lower. Conclusion Remifentanil combined with propofol anesthesia is effective in laparoscopic cholecystectomy, which can shorten the recovery time of patients, has little impact on hemodynamics, is conducive to the recovery of cognitive function and reduce the occurrence of adverse reactions.

Long term safety of indocyanine green combined with methylene blue for sentinel lymph node biopsy in breast cancer

WU Ningyu, LIANG Fengxing, ZHU Gang

2022, 10(1):  50. 

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Objective To observe the long-term safety of indocyanine green combined with methylene blue in tracing sentinel lymph node biopsy in breast cancer. Method 40 breast cancer patients with axillary negative clinical findings in Nanhai Maternal and Child Health Hospital in Foshan City from June 2017 to June 2018 were treated with indocyanine green combined with methylene blue for sentinel lymph node biopsy and followed up for 06 months in 2021. The situation of postoperative upper limb lymphedema was counted, and the regional lymph node recurrence, disease-free survival and overall survival rate were analyzed. Result In the telephone follow-up, 40 patients completed the follow-up. Among the 10 patients who underwent ALND operation, 1 patient (10.00%) had postoperative upper limb lymphedema, while among the other 30 patients who underwent SLNB only, 3 patients (10.00%) had postoperative upper limb lymphedema, which improved after symptomatic treatment. There was no significant difference between the two groups (P ＞ 0.05). Of the 40 patients, 3 had regional lymph node recurrence, 2 had contralateral breast cancer, and 4 had distant metastasis. Among the 10 patients receiving ALND, 1 had regional lymph node recurrences (10%), 1 had contralateral breast cancer (10%) and 3 had distant metastasis (10%), while only SLNB patients had regional lymph node recurrence (3). There were 1 cases of contralateral breast cancer (3.33%) and 3 cases of distant metastasis (10%). The difference between the two groups was not significant (P ＞ 0.05). 2 patients died of distant metastasis of breast cancer during the follow-up period, with a mortality rate of 6.67%. DFS was 85.00%, 0s was 95.00%. Conclusion Indocyanine green combined with methylene blue for tracing sentinel lymph node biopsy in breast cancer has long term safety and is worthy of clinical application.

Clinical efficacy analysis of different thyroid cancer resection in patients with thyroid cancer 

LIU Siping

2022, 10(1):  56. 

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Objective To investigate the inflammatory index analysis of thyroid cancer resection in thyroid cancer patients. Method Thirty patients of thyroid cancer treated at Xuancheng Renjie Hospital from January 2019 to September 2021 were randomly divided into two groups, the control group used the thyroid lobectomy plus contralateral subtotal resection, and the observation group

used the thyroid lobectomy, compared the two groups with the operating indexes, complication rate, thyroid hormone index, parathyroid hormone (PTH) and blood calcium levels. Result The operation time, intraoperative bleeding amount, postoperative analgesia time and hospital stay in the observation group were shorter than those in the control group (P ＜ 0.05);The incidence of incision infection, hypocalcemia, hypothyroid function, and recurrent laryngeal nerve injury was significantly lower than that in the control group (P ＜ 0.05); Total triiodothyronine(TT3), total thyroxine (TT4), PTH and blood calcium were significantly higher than the control group (P ＜ 0.05), and free triiodothyronine (FT3), free thyroxine (FT4) were significantly lower than the control group (P ＜ 0.05). Conclusion Thyroid lobectomy has small trauma to thyroid cancer and low incidence of postoperative complications, which can partially retain the physiological function of the thyroid, maintain thyroid hormone levels, and avoid the continuous reduction of PTH and blood calcium levels, which has positive clinical significance.

Clinical analysis of laparoscopy combined with choledochoscopy in the treatment of common bile duct stones

LIANG Jingui

2022, 10(1):  62. 

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Objective To investigate the clinical effect of laparoscopy in patients. Method 40 cases of gallbladder gallstone patients with gallstone, 40 patients in Yizheng Hospital of Nanjing Gulou Hospital Group from May 2018 to May 2021 were randomly divided into two groups, study group 20 cases using conventional open treatment of gallstone, control group 20 cases using laparoscopic combined endoscopic therapy. The two groups of patients with total efficiency, quality of life index score, hospital time, surgical bleeding and operation time were compared. Result After treatment, the total efficiency and quality of life index were higher in the study group than in the control group, the hospital stay time, operation time and surgical bleeding volume were lower than in the control group, and the incidence of related complications was lower than in the control group (P ＜0.05). Conclusion The clinical treatment of patients reduces the incidence of related complications and is beneficial to the recovery.

Safety and feasibility of complete mesocolon excision in the surgical treatment of colon cancer in the elderly patients

SU Baofei, SONG Jiqiang

2022, 10(1):  67. 

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Objective To investigate the safety and feasibility of complete mesocolon resection in elderly patients with colon cancer. Method 74 elderly patients with colon cancer treated in Xintai Second People's Hospital from March 2018 to March 2020 were divided into intervention group and control group by doubleblind method, with 37 cases in each group. The operation method of the intervention group was complete mesocolon excision, and the operation method of the control group was traditional colectomy. The incidence of complications, the recurrence rate of colon cancer, the number of lymph node clearance, the amount of

postoperative bleeding, the survival rate of 1 and 3 years after operation and the effective rate of operation were compared between the two groups. Result The incidence of postoperative complications and colon cancer recurrence in the intervention group were lower than those in the control group, There was significant difference (P ＜ 0.05); the number of lymphatic clearance in the intervention group was more than that in the control group, and the amount of postoperative bleeding was less than that in the control group, the difference was significant (P ＜ 0.05); the 1-year and 3-year survival rate and operation effective rate in the intervention group were higher than those in the control group, the difference was significant (P ＜ 0.05). Conclusion The effect of complete mesocolon excision in elderly patients is excellent, the amount of postoperative bleeding is less, and the postoperative survival rate of elderly patients is significantly improved, which has high safety and feasibility.

Efficacy and safety analysis of neoadjuvant chemoradiotherapy combined with total mesenterectomy for locally advanced rectal cancer

SHANG Xiaowen, WU Dongbo (corresponding author), SONG Xuemin, XIE Dezhi, XU Junyi, TANG Yangyang, LUO Wen, YU Pengcheng

2022, 10(1):  72. 

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Objective To analyze the efficacy and safety of neoadjuvant chemoradiotherapy combined with total mesenterectomy in the treatment of locally advanced rectal cancer. Method The clinical data of 100 patients with locally advanced rectal cancer who underwent total mesenterectomy in The Fourth Affiliated Hospital of Guangxi Medical University from June 2017 to June 2020 were retrospectively analyzed, and they were divided into nCRT group (n=50) and non nCRT group (n=50) according to whether they underwent neoadjuvant chemoradiotherapy (nCRT) or not. The clinical indicators, postoperative complications and tumor stage before and after neoadjuvant chemoradiotherapy were compared between the two groups. Result The tumor stage decreased significantly after neoadjuvant radiotherapy and chemotherapy. The amount of intraoperative bleeding, operation time, postoperative hospital stay and protective stoma rate in nCRT group were higher than those in non nCRT group, and the number of lymph node dissection and anus preservation rate were lower than those in non nCRT group (P ＜ 0.05). There was no significant difference in the overall incidence of complications between nCRT group and non nCRT group (P ＞ 0.05). Conclusion Neoadjuvant chemoradiotherapy combined with total mesenterectomy can increase the protective stoma rate, prolong the operative time and increase the operative bleeding in rectal cancer patients, but can significantly reduce the tumor stage.

Clinical effect of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis

CHEN Zheng, DING Junnan

2022, 10(1):  77. 

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Objective To investigate the clinical effect of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis. Method 160 patients with acute pancreatitis treated in Beijing Integrated Traditional Chinese and Western Medicine Hospital from February 2015 to March 2021 were randomly divided into two groups, 80 cases in each group. Both groups were routinely treated with gastrointestinal decompression, inhibition of gastric acid and pancreatic juice secretion, antiinflammatory

and rehydration. The control group was additionally treated with low molecular weight heparin calcium, and the observation group was additionally treated with ulinastatin+low molecular weight heparin calcium. The inflammatory factors [interleukin(IL)-1, IL-10, tumor necrosis factor (TNF)-α] and intestinal mucosal barrier related indexes [diamine oxidase (DAO), D-lactic acid and urinary lactulose / mannitol] were observed and compared between the two groups, and the outcome of the disease. Result The levels of IL-1 and TNF -α in the observation group were lower than those in the control group 7 days after treatment. The levels of IL-10 in the observation group were higher than those in the control group (P ＜ 0.05); The levels of Dao, D-lactic acid and urinary lactulose/mannitol in the observation group were lower than those in the control group (P ＜ 0.05); The disease remission rate in the observation group was higher than that in the control group (P ＜ 0.05). Conclusion Ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis can help to reduce the

inflammatory response, improve the damage of intestinal mucosa, and is conducive to the remission and benign prognosis of the disease.

The study on clinical efficacy of modified Dahuang Mudan pi decoction combined with antibiotics in the treatment of patients with acute simple appendicitis

BEI Jinlou

2022, 10(1):  82. 

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Objective To analyze the clinical efficacy of Jiawei Dahuang Mudan pi Decoction combined with antibiotics in the treatment of patients with acute simple appendicitis. Method A total of 124 patients with acute simple appendicitis admitted to Zhaoping County Hospital of Traditional Chinese Medicine in Hezhou from August 2019 to October 2021 were selected as the research subjects. After randomization, different treatment measures were taken. Among them, 62 patients in the control group were treated with antibiotics, and the study group 62 patients were treated with modified Dahuang Mudan pi Decoction on the basis of antibiotic therapy. The changes in clinical symptom scores, treatment effects, and adverse reactions were observed and compared between the two groups before and after treatment. Result After treatment, the scores of symptoms such as nausea, vomiting, and fatigue in the study group were lower than those in the control group (P ＜ 0.05). Compared with the control group, patients in the study group had better treatment effects and lower probability of adverse reactions (P ＜ 0.05). Conclusion The treatment of acute simple appendicitis with modified Dahuang Mudan pi Decoction combined with antibiotics has good clinical results. The patient's symptoms have improved well without increasing the occurrence of adverse reactions.

Effect of Rupi Sanjie tablets combined with tamoxifen on progesterone and long-term prognosis in patients with benign breast hyperplasia

REN Hongbing

2022, 10(1):  86. 

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Objective To study the effect of Rupi Sanjie tablets combined with tamoxifen on progesterone level and long-term prognosis in patients with benign breast hyperplasia. Method 60 patients with benign breast hyperplasia who were diagnosed and treated in the Affiliated Shunde Hospital of Jinan University from November 2019 to November 2020 were randomly divided into two groups (a coin toss random method), with 30 in the control group and 30 in the observation group. The control group was treated with tamoxifen as a single agent, and the observation group was treated with Rupi Sanjie tablets combined with tamoxifen, the effects of progesterone and long-term prognosis between the two groups were compared. Result There was no significant difference in curative effect between the two groups (P ＞ 0.05). The improvement of breast pain time, tumor diameter and serum progesterone level in the observation group was better than that in the control group after treatment, and the difference was statistically significant (P ＜ 0.05). Conclusion Rupi Sanjie tablet combined with tamoxifen has a significant effect in the treatment of benign breast hyperplasia. It can promote the recovery of progesterone as soon as possible.

Feasibility study of early postoperative activity plan for daytime laparoscopic cholecystectomy patients under the enhanced recovery after surgery concept

LI Ya, LU Jing, ZHU Hongmei, ZHOU Chuanyu

2022, 10(1):  90. 

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Objective To explore the feasibility of applying the enhanced recovery after surgery (ERAS) concept to the rehabilitation treatment plan for early postoperative activities of daytime laparoscopic cholecystectomy (LC) patients. Method Randomly enrolled 100 patients undergoing LC in Deyang People's Hospital from January 2018 to January 2021, according to different nursing methods, they were divided into control group and ERAS group, with 50 cases in each group. Patients in ERAS group were treated with the concept of daytime ward ERAS for perioperative management, and patients in control group were treated with traditional perioperative management in general ward. The intraoperative and postoperative related indexes of the two groups and the effect of ERAS concept on the early postoperative activities of the patients were compared. Result The earliest time of getting out of bed in ERAS group was 6.8h and the latest was 26.3h, The average time of getting out of bed was

(8.2 ± 0.8) h, including 90% within 12 hours and 6% within 12 ～ 24 hours, which were significantly higher than those in the control group (P ＜ 0.05); 88.0% (44/50) of patients in ERAS group had the intention of early activities, the satisfaction rate of first getting out of bed activities was 84.0% (42/50), and the rehabilitation self-efficacy score was (70.22 ± 5.32), which was significantly higher than that in the control group (P ＜ 0.05); The eating time and postoperative gastrointestinal ventilation time in ERAS group were significantly shorter than those in the control group, the pain score at 6h and 12h after operation was lower, and the incision healing time was shorter, the difference was significant (P ＜ 0.05). There were no complications such as bleeding, urinary retention, hematoma in the two groups. Only 1 patients developed nausea in ERAS group, and 1 patients had abdominal distension, the incidence of adverse reactions was significantly lower than that of the control group (P ＜ 0.05). Conclusion It is feasible to apply the ERAS concept to the rehabilitation treatment plan for early postoperative activities of LC patients in the day ward, which is conducive to the postoperative rehabilitation of the patients and improves the prognosis of the patients.

Application value of clinical nursing pathway in perioperative nursing of thyroid tumor

XU Aili

2022, 10(1):  96. 

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Objective To explore the application value of clinical nursing pathway in perioperative nursing of thyroid tumor. Method 68 patients with thyroid tumor treated in the General Surgery Department of Shuyang County Zhongxing Hospital from October 2019 to April 2021 were selected as the research object. They were randomly divided into control group (34 cases, routine nursing) and observation group according to different perioperative nursing methods. Result The time of getting out of bed (8.14±1.06)h, hospital stay (5.11±1.21)d and indwelling time of drainage tube (46.12±5.38)h in the observation group were significantly shorter than those in the control group (12.77 ± 2.54)h, (7.12 ± 1.05)d and (51.25 ± 3.68)h (P＜0.05); The incidence of complications in the observation group was 8.8% lower than 29.4% in the control group, with significant difference (P ＜ 0.05); The nursing satisfaction of patients in the observation group was 97.1% higher than 76.5% in the control group, with significant difference(P ＜ 0.05). Conclusion Clinical nursing pathway intervention in perioperative nursing of thyroid tumor can significantly promote postoperative rehabilitation, reduce surgical complications and improve patient satisfaction.

Effect analysis of humanized nursing model in operating room nursing

JU Xingxing

2022, 10(1):  102. 

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Objective To explore the application effect of humanized nursing mode in operating room nursing. Method 100 surgical patients in the Operating Room of Traditional Chinese Medicine Hospital of Rugao were randomly divided into humanized nursing group and control group. The control group took routine operating room nursing program. The humanized nursing group adopted the

humanized nursing mode scheme on the basis of the control group. The nursing satisfaction and the incidence of adverse events were compared between the two groups. Result The total nursing satisfaction of patients in humanized nursing group was 98%, and that of patients in control group was 84.0%, the total satisfaction of the humanized nursing group was significantly higher than that of the control group (P ＜ 0.05). The incidence of adverse events such as hypothermia, infection and delayed awakening in the humanized nursing group within 3 days was significantly lower than that of the control group (all P＜ 0.05). The scores of psychological function, physiological function, social function and material life in the humanized nursing group were higher than those in the control group (all P ＜ 0.05). Conclusion The application of humanized nursing management in the nursing management of operating room can significantly improve patients' satisfaction and postoperative quality of life, and effectively reduce the incidence of nursing adverse events.