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    Laparoscopic total extraperitoneal hernia repair for the treatment of inguinal hernia with different fixation methods
    HUANG Jianfeng, SUN Zhenzhi, LIU Yuhui, WANG Tao, JIN Jitao, NIE Yong
    Journal of General Surgery for Clinicians    2021, 9 (1): 3-.  
    Abstract249)            Save
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    Clinical study of laparoscopic high ligation of peritoneal hernia sac without injury of hernia needle in the treatment of indirect inguinal hernia in children
    CHEN Rongyu, XU Guixian, YE Yingchao
    Journal of General Surgery for Clinicians    2021, 9 (2): 3-.  
    Abstract212)            Save

    Abstract: Objective To investigate the clinical value of laparoscopic high ligation of hernia sac without injury by hernia needle in the treatment of indirect inguinal hernia in children. Methods 90 children with indirect inguinal hernia admitted to Gaozhou Maternal and Child Health Hospital from January 2018 to June 2019 were randomly divided into traditional operation (group A), hernia needle + laparoscopy (group B) and laparoscopy (Group C) with 30 patients of each group. Group A was treated with traditional high ligation of hernia sac, group B was treated with laparoscopic high ligation of hernia needle without injury of peritoneal hernia sac, and group C was treated with laparoscopic high ligation of hernia sac. Results The operation time of group A was longer than that of group B and group C, and the incidence of complications was higher, the difference was significant (P<0.05); The incision length, intraoperative blood loss, autonomous activity time and hospitalization time of the three groups were compared. The results of group B were better than those of group A and group C, and the results of group A were the worst, with significant difference (P<0.05). Conclusion Laparoscopic high ligation of hernia sac without injury of hernia needle in the treatment of indirect inguinal hernia in children has the advantages of fast, minimally invasive and safe, which can significantly promote the physical rehabilitation of children after operation.

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    A comparative study in the treatment of postoperative low extremity deep vein thrombosis
    QI Haoshan, ZHAO Juncheng, ZHANG Kun, LI Dalin, CHEN Yunhui, YAN Jingqiang, HUANG Shujie
    Journal of General Surgery for Clinicians    2021, 9 (3): 2-.  
    Abstract188)            Save

    Abstract: Objective To estimate the risk of bleeding after thrombolytic therapy in patients with secondary deep venous thrombosis, in order to find a better therapy for higher bleeding risk postoperative patients. Methods 48 patients diagnosed postoperative DVT were divided into PMT group included 27 patients and CDT group included 21 patients. The PMT group was treated by PMT or PMT+CDT, the CDT group given thrombolysis only directed by catheterization. The effects of thrombus removal and later follow-up effects in the two groups were compared. Results Thrombus degradation was obviously better in PMT group compared with the CDT group [(90.21±17.28)% vs (75.65±27.59)%]. Lower dosage of urokinase [(105.45±126.34)WU vs (345.87±118.38)WU] and shorter hospital stays [(6.72±1.88)d vs (8.82±2.97)d],less time in bed[(2.90±2.71)d vs( 5.40±2.06)d]was also detected in PMT group patients. There is nonmajor bleeding occurred in both groups. Nonmajor bleeding was higher in PMT group, but they did not achieve statistical significance(P>0.05). In later follow-up, PTS Villalta scores of 12 and 24 months in PMT were better than CDT. Conclusion Both PMT and single CDT were both effective and safety methods in treating postoperative DVT more than one week, associated low bleeding risk,however the strategy combined PMT had the advantage in low dosage of urokinase using, better thrombus eliminating, and reducing the hospital stays and time in bed. Villalta score was lower in PMT-group, connected with lower risk of PTS morbidity.

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    Comparative analysis of the effect of laparoscopic surgery and traditional open surgery in the treatment of inguinal hernia
    WANG Ruihong, LU Yibin
    Journal of General Surgery for Clinicians    2022, 10 (4): 75-.  
    Abstract180)            Save

    Objective To analyze the effect of laparoscopic surgery and traditional open surgery in the treatment of inguinal hernia. Method From July 2018 to July 2021, 50 male patients with inguinal hernia from Xingpu Hospital in Suzhou Industrial Park were selected and randomly divided into the reference group (treated with traditional open surgery) and the research group (treated with laparoscopic surgery) by using the method of random color ball sampling. There were 25 patients in each group, and the surgical indicators and postoperative quality of life of the two groups were compared. Result The incidence of complications such as scrotal hematoma and incision infection in the study group was significantly lower than that in the control group (P < 0.05); The operation time, hospital stay and bed rest time of the patients in the study group were shorter than those in the reference group, and the amount of intraoperative bleeding was less than that in the reference group, with a significant difference (P < 0.05). The post-operative pain scores of patients in the study group were lower than those in the reference group, and the quality of life scores were higher than those in the reference group, with significant differences (P < 0.05). Conclusion Laparoscopic surgery is more effective in the treatment of inguinal hernia, which can reduce complications, optimize surgical indicators, promote postoperative recovery, reduce pain. 

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    Clinicopathological characteristics and prognosis of invasive ductal/lobular mixed carcinoma, invasive lobular carcinoma and invasive ductal carcinoma of breast
    LENG Minfang, CHENG Wende, XIAO Xiaoqin, LIU Feng
    Journal of General Surgery for Clinicians    2021, 9 (1): 24-.  
    Abstract172)            Save
    Abstracts: Objective To study the pathological characteristics of breast infiltrative ductal / lobular mixed carcinoma(IDC-L), infiltrative lobular carcinoma(ILC) and infiltrative ductal carcinoma(IDC). Methods From September 2011 to September 2020,254 breast cancer patients were selected, Among them, there were 18 cases of IDC-L, 20 cases of ILC and 216 cases of IDC. The prognosis of the three groups of patients was observed. Results IDC- L, ILC and IDC patients had significant differences in age, tumor size, multicentric lesions, vascular invasion, HER2 status, Ki-67 expression. IDC-L patients had younger onset age, more tumor diameter>2.0 cm, while IDC patients had less multicentric lesions and vascular invasion, while HER2 positive rate and Ki-67 high expression ratio in IDC-L and ILC patients were lower than IDC, the difference was statistically significant(P<0.05). Age, climacteric state, tumor size, lymph node state, multicentric lesions, lymphatic vessel invasion, HER2 state and Ki-67 expression were all the influencing factors of clinic pathological differences. Breast cancer-free interval and overall survival were related to tumor size, lymph node status, lymphatic vessel invasion and Ki-67 expression (P<0.05). Conclusion In breast cancer patients, the clinicopathological characteristics of ILC and IDC-L are similar to each other, but there are obvious differences among ILC, IDC-L and IDC. The breast cancer patients can be differentiated clinically and treated better.

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    Effect of moxa stick moxibustion on gastrointestinal function recovery in patients after laparoscopic appendectomy
    MEI Yaping, SONG Ziping, YIN Mo
    Journal of General Surgery for Clinicians    2022, 10 (4): 87-.  
    Abstract165)            Save

    Objective To investigate the effect of moxa stick moxibustion on gastrointestinal function recovery of patients after laparoscopic appendectomy. Method From June 2021 to December 2021, 74 patients with laparoscopic appendicitis in Taixing Hospital of Traditional Chinese Medicine were selected and randomly divided into control group (n=37) and study group (n=37). The control group received routine postoperative care, while the study group received moxibustion intervention on this basis. Objective and subjective indexes of gastrointestinal function recovery were compared between the two groups. Result After intervention, the time of first exhaust, first defecation and recovery of bowel sounds in the study group were lower than those in the control group (P < 0.05). Before intervention, there was no significant difference in the subjective indexes of gastrointestinal function recovery between the two groups (P > 0.05); After intervention, the abdominal distension syndrome and VAS score in the study group were lower than those in the control group (P < 0.05). Conclusion Through this study, it can be seen that the implementation of moxa stick moxibustion intervention in patients after laparoscopic appendicitis surgery can significantly improve gastrointestinal function, shorten the recovery time of rapid exhaust, defecation and bowel sounds after surgery, relieve pain, improve abdominal distension syndrome, accelerate the improvement of the patient's condition, and facilitate the patient's recovery.

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    Meta analysis of the application effect of clinical nursing pathway in patients with thyroid tumor surgery
    GONG Lili, CHEN Chen
    Journal of General Surgery for Clinicians    2021, 9 (2): 37-.  
    Abstract163)            Save

    Objective To explore the application effect of clinical nursing pathway in patients with thyroid tumor surgery. Methods CNKI, VIP database,Wanfang database, CBMdisc and other databases were searched to search the clinical randomized controlled trials or clinical controlled trials of clinical nursing pathway in patients with thyroid surgery from when building the library to June 2019.

    The literature was screened and extracted. RevMan 5.0 software was used to evaluate the quality of literature. Finally, RevMan 5.3 was used for analysis. Results A total of 19 clinical controlled studies were included, including 2371 patients with thyroid surgery, including 1193 patients with the clinical nursing pathway (experimental group) and 1178 patients with the traditional clinical nursing (control group). The average hospitalization time of the experimental group was significantly less than that of the

    control group, the satisfaction and knowledge mastery of the experimental group was significantly higher than that of the control group, the bed rest time of the experimental group was significantly lower than that of the control group, and the incidence of complications of the experimental group was significantly lower than that of the control group. Conclusion The implementation of clinical nursing pathway for patients with thyroid surgery can significantly shorten the average length of hospital stay, improve patient satisfaction and mastery of knowledge, and reduce the occurrence of complications.

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    Effect of Xiaoyao Loubei decoction combined with emotional therapy of traditional chinese medicine on breast hyperplasia
    LUO Jie
    Journal of General Surgery for Clinicians    2022, 10 (2): 84-.  
    Abstract149)            Save

    Objective To explore and analyze the effect of Xiaoyao Loubei Decoction combined with emotional therapy of traditional chinese medicine on hyperplasia of mammary glands. Method A total of 126 patients with hyperplasia of mammary glands admitted to Xingbin District People's Hospital of Laibin from June 2018 to June 2020 were selected as the research objects, and randomly divided into the control group and the observation group, with 63 cases in each group. The control group was treated with Xiaoyao Loubei Decoction; The observation group was treated with emotional therapy of traditional chinese medicine on the basis of the control group, and the treatment effect, sex hormone levels and symptoms and signs scores before and after treatment were compared between the two groups. Result The effective rate of treatment in the observation group was significantly higher than that in the control group (P < 0.05). After 3 months of treatment, the serum progesterone levels in both groups increased, while the serum estradiol and prolactin levels decreased. After treatment, the serum progesterone

    levels in the observation group were significantly higher than those in the control group (P < 0.05), and the serum estradiol and prolactin levels were significantly lower than those in the control group (P < 0.05). After 3 months of treatment, the scores of symptoms and signs in both groups decreased, and the observation group was significantly lower than the control group (P < 0.05). Conclusion Xiaoyao Loubei Decoction combined with emotional therapy of traditional chinese medicine can effectively improve the treatment efficiency of patients with hyperplasia of mammary glands, reduce the level of sex hormones and symptoms of patients.

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    The influence of chewing gum for gastrointestinal function after surgery in laparoscopic left hemicolectomy for patiens with colon cancer and its mechanism of action
    HUANG Yongheng, WU Guozhong, PANG Shaochun, PAN Tiansheng, LIN Liangxue
    Journal of General Surgery for Clinicians    2021, 9 (2): 14-.  
    Abstract148)            Save

    Objective To investigate the gastrointestinal function of chewing gum after laparoscopic resection of left colon cancer and explore its mechanism of action. Methods 65 patients underwent laparoscopic resection of left colon cancer were selected in the department of general surgery between January 2018 to September 2020 in Nongken Central Hospital. These patients were divided into research group (n=35) and control group (n=30). The patients in the research group chewed 2 pieces of xylitol gum three times daily for 30 minutes after surgery, while control group received traditional managements. The levels of procalcitonin (PCT) and C reactive protein (CRP) were examined with peripheral blood on day 1 and 3 after operation. Postoperative exhaust and defecation time, postoperative

    hospital stays and postoperative inflammatory factor level of the two groups was compared. Results All the 65 patients recovered and were discharged smoothly, and the postoperative exhaust and defecation time and postoperative hospitalization days in the research group were shorter than those in the control group (P<0.05). The levels of inflammatory factors in postoperative day 1 and day 3, PCT and CRP were lower than the control group(P<0.05). Conclusions Chewing gum after laparoscopic resection of the left colon cancer can promote the early recovery of gastrointestinal function, and its mechanism may inhibit the release of inflammatory factors and promote gastrointestinal motility.

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    Advances in surgical treatment of intraductal papillary mucinous neoplasm of the pancreas
    YUAN Jiaqi, CHEN Xiaobin, HOU Lichao
    Journal of General Surgery for Clinicians    2021, 9 (2): 28-.  
    Abstract146)            Save

    Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a kind of mucinous tumor involving the main pancreatic duct or branch pancreatic duct, and lacks the characteristics of mucinous cystadenoma. IPMN may progress to pancreatic ductal adenocarcinoma. At present, many studies are exploring the pathogenesis and diagnosis of IPMN, and have made progress. However, there is no complete unification of its surgical indications and surgical methods. In this paper, the progress of IPMN treatment was discussed from the aspects of epidemiology, classification, malignancy evaluation, surgical treatment and prognosis.

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    Effect of ultrasound-guided continuous transversus abdominis plane block on postoperative analgesia and early recovery in patients undergoing radical resection of rectal cancer
    HUANG Zhidong, LI Chaoyang, YANG Jixiong
    Journal of General Surgery for Clinicians    2021, 9 (2): 7-.  
    Abstract142)            Save

    Objective To investigate the effect of continuous transverse abdominal plane block on postoperative analgesia and early recovery in patients with radical rectal cancer. Methods 56 patients with rectal cancer treated at the Second Affiliated Hospital of Guangdong Medical University from July 2017 to July 2019 were selected, which were divided into 28 cases, patients with controlled intravenous

    analgesia, patients with an ultrasound-guided continuous transverse abdominal plane block. The amount of fluid access and anesthetic use during patient surgery, The numerical rating scale (NRS) of 2h, 6h, 12h, 24h, 48h, 72h cough and resting were recorded; Patient relief, hospitalization time, first exhaust time after surgery, first bed time were recorded; The adverse reactions and complications such as nausea and vomiting after surgery were recorded; Patient recovery was assessed to a postoperative recovery quality scale. Results There was no significant difference between surgical time, anesthesia time, urine volume, propofol dosage, intraoperative bleeding volume, and total fluid volume in the two groups (P>0.05), The usage quantity of Remifentanil in study group less than the control group, The difference is significant (P<0.05); Postoperative 2h, 6h, 12h, 24h, The NRS at cough and resting were lower than the control group, the difference is significant (P<0.05); Postoperative 48h、72h, there was no significant difference

    in the NRS at coughing and resting (P>0.05); Preoperative 1d, there was no significant difference in the total score, emotional state, self-care ability, physical comfort, pain, and psychological support scores of the two groups (P>0.05); Postoperative 3d, total score, physical comfort, emotional state, pain, and psychological support scores were higher than in the control group, the difference is significant (P<0.05); There was no significant hospitalization time difference between the two groups (P>0.05); The first hospital discharge time and the first postoperative exhaust time were shorter than the control group, the rates of nausea, vomiting, relief and analgesia were lower than in the control group, the difference was significant (P<0.05). Conclusion Ultrasonic-guided continuous transverse abdominal plane block can significantly improve the postoperative cough and resting analgesia effect in patients with radical rectal cancer, and significantly improve the early recovery condition.

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    Clinical study on combined treatment of laparoscopy, choledochoscope and duodenoscopy for senile mild biliary pancreatitis
    JIAO Zhendong, GUO Zhihua, LIU Yimin
    Journal of General Surgery for Clinicians    2021, 9 (3): 8-.  
    Abstract141)            Save

    Abstract: Objective To evaluate the safety and effectiveness of combination of laparoscopy, choledochoscope and duodenoscope combination of three glasses in the treatment of senile mild biliary pancreatitis and traditional open cholecystectomy plus choledocholithotomy. Methods 80 patients with mild biliary pancreatitis from January 2013 to December 2020 in the Hepatobiliary Surgery Department of Baoji People's Hospital were retrospectively analyzed. The patients received laparotomy or threemirror combined surgery respectively. According to different surgical methods, they were divided into control group (traditional laparotomy) and observation group (combined therapy of three mirrors) with 40 cases each. Two groups’ postoperative complications, intraoperative blood loss, stone removal success rate, surgical success rate, severe pancreatitis rate, gastrointestinal function recovery time, blood amylase recovery time, hospitalization time and hospitalization expenses were compared. Results The incidence rate of postoperative complications and intraoperative blood loss of observation group were lower than that of control group. However, there was no significant difference between the two groups in stone clearance rate, severe pancreatitis rate and operation success rate. The hospitalization time and gastrointestinal function recovery time of the observation group are lower than those of the control group. In addition, compared with endoscopic retrograde cholangiopancreatography treatment and laparoscopic cholecystectomy + laparoscopic common bile duct exploration sequential inertia treatment after 1~2 weeks, the recovery time of blood amylase in the open surgery is significantly prolonged. However, there was no significant difference in hospitalization expenses between the two groups. Conclusion Combined treatment of three glasses for elderly senile biliary pancreatitis is a safer and more effective method. It has fewer surgical complications, shorter hospital stay, but requires secondary surgery.

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    Analysis of the effect of manual lymphatic drainage nursing on relieving postoperative lymphedema and axillary reticulum syndrome in patients with breast cancer
    XIAO Qiumei, PANG Meirui, CHEN Wanxia
    Journal of General Surgery for Clinicians    2023, 11 (1): 64-.  
    Abstract141)            Save

    Objective To analyze the intervention effect of manual lymphatic drainage nursing on relieving postoperative lymphedema and axillary reticulum syndrome of breast cancer. Method From January 2018 to January 2020, 50 patients with lymphedema and axillary reticulum syndrome after breast cancer surgery were selected from Zhanjiang Maternal and Child Health Care and Family Planning Service Center. They were randomly divided into two groups by double-blind method. The control group was 25 patients, receiving routine care; 25 patients in the observation group were treated with manual lymphatic drainage based on the control group; The intervention effect and symptom relief of the two groups were compared. Result The effective rates of the patients in the observation group were 72.0%, 80.0% and 100.0% respectively after 3, 6 and 12 months of intervention, which were higher than 44.0%, 56.0% and 72.00% in the control group (P < 0.05). The decrease of the difference in circumference of the patients in the observation group after 3, 6 and 12 months of intervention was higher than that in the control group, and the abduction angle of the shoulder joint of the affected limb at 1, 3, 6 and 12 months after intervention was higher than that in the control group, and the time for the postoperative tightness, cord structure, numbness and pain of the affected limb was shorter than that in the control group (P < 0.05). After 1 month of intervention, the scores of daily social function, upper limb activity function and upper limb symptoms in the observation group were lower than those in the control group (P < 0.05). Conclusion Manual lymphatic drainage nursing can alleviate the clinical symptoms of lymphedema and axillary reticulum syndrome after breast cancer surgery, increase the range of motion of the affected limb, and have a good intervention effect.

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    Clinical application value of ruiyun procedure for hemorrhoid in the treatment of mild to moderate hemorrhoids
    NI Jiamin, SUN Yan
    Journal of General Surgery for Clinicians    2022, 10 (3): 140-.  
    Abstract140)            Save

    Objective To analyze the value of ruiyun procedure for hemorrhoid (RPH) in the treatment of mild to moderate hemorrhoids. Method 96 patients with mild to moderate hemorrhoids treated in Zhangjiagang Hospital Affiliated to Suzhou University from January 2019 to March 2022 were selected as the research objects. The clinical data were retrospectively analyzed. The patients in the control group (n=46) were treated with traditional surgery, and the patients in the observation group (n=50) were treated with RPH. The surgical indicators, postoperative complications, treatment effects, quality of life and symptom scores of the two groups were compared. Result The postoperative pain score of the observation group was lower than that of the control group, the amount of intraoperative bleeding was less than that of the control group, and the healing time and operation time were shorter than those of the control group (P < 0.05). The incidence of complications in the observation group was 6.00%,

    significantly lower than 23.91% in the control group (P < 0.05). The total effective rate in the observation group was 96.00%, which was significantly higher than 78.26% in the control group(P < 0.05). The scores of quality of life in the observation group were higher than those in the control group after treatment, and the symptom scores after intervention were lower than those in the control group (P < 0.05). Conclusion RPH is effective in the treatment of mild to moderate hemorrhoids with less complications.

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    Endoscopic retrograde appendicitis treatment for acute uncomplicated appendicitis: therapeutic effect and safety evaluation
    LI Xin
    Journal of General Surgery for Clinicians    2021, 9 (1): 31-.  
    Abstract139)            Save
    Abstract: Objective To analyze the efficacy and safety of endoscopic retrograde appendicitis treatment for acute uncomplicated appendicitis. Methods The subjects of this study were 80 patients with acute uncomplicated appendicitis admitted to Foshan Women and Children Hospital from July 2018 to May 2020. They were divided into conventional groups (laparoscopic appendectomy) according to different treatment methods. Study group (retrograde endoscopic appendicitis treatment), 40 cases in
    each group. Compare the levels of serum tumor necrosis factor (TNF-α), C-reactive protein (CRP), and interleukin (IL) -6 before and after treatment in the two groups, as well as the time in bed, hospitalization time, operation time, and incidence of complications , To explore the efficacy and safety of endoscopic retrograde appendicitis treatment. Results Before treatment, the levels of TNF-α, CRP and IL-6 of the two groups were not statistically different (P>0.05). After treatment, the levels of TNF-α, CRP,
    and IL-6 in the study group were lower than those in the conventional group (P<0.05); the bed time, hospital stay, and operation time of the study group were shorter than those in the conventional group (P<0.05); The complication rate of the group was 2.50%, which was lower than that of the conventional group (15.00%,P<0.05). Conclusion The use of endoscopic retrograde appendicitis treatment for acute uncomplicated appendicitis is less invasive, can reduce surgical stress response, is very conducive to the rapid recovery of patients after surgery, and has good safety.

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    Journal of General Surgery for Clinicians    2019, 0 (3): 1-.  
    Abstract139)            Save
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    Application value of fine capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve in total thyroidectomy for patients with thyroid cancer
    JIN Xiongwei, LI Hongshuai, YANG Zuohao, LI Manzhi, ZHANG Hao
    Journal of General Surgery for Clinicians    2022, 10 (1): 2-.  
    Abstract139)            Save

    Objective To explore the application value of fine capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve in total thyroidectomy for thyroid cancer patients. Method 90 patients with thyroid cancer in Dongguan Kanghua Hospital from January 2018 to September 2020 were selected. They were randomly divided into two groups, with 45 cases in each group. The control group was treated with conventional total thyroidectomy and inferior thyroid artery exposure of recurrent laryngeal nerve, while the observation group was treated with refined capsule anatomy combined with cricothyroid space exposure of recurrent laryngeal nerve. The operation conditions, changes of thyroid function indexes before and after operation, postoperative complications and recurrence after 6 months of follow-up were compared between the two groups. Result There was no significant difference in the operation time, intraoperative blood loss and the number of lymph node dissection between the two groups (P > 0.05); The detection results of serum parathyroid hormone and Ca2+ in the observation group on 1 day and 3 days after operation were higher than those in the control group, and the difference was significant(P < 0.05); The incidence of recurrent laryngeal nerve injury, hypoparathyroidism and hypocalcemia in the observation group were lower than those in the control group, the difference between the data was significant (P < 0.05); there was no significant difference in the recurrence rate of the two groups after 6 months of follow-up (P > 0.05). Conclusion In total thyroidectomy for patients with thyroid cancer, fine capsule anatomy combined with exposure of recurrent laryngeal nerve in cricothyroid space is beneficial to protect the function of recurrent laryngeal nerve and parathyroid gland.

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    A signature for predicting the prognosis of breast cancer based on aging-related genes
    LI Xiaoping, QIU Chaoran, YU Qihe, CHEN Qiyang, FANG Yuewan
    Journal of General Surgery for Clinicians    2022, 10 (2): 6-.  
    Abstract138)            Save

    Objective To screen out the aging genes that are significantly related to the prognosis of breast cancer through bioinformatics. Method Clinical data and mRNA sequencing data were downloaded from the cancer genome atlas (TCGA) database collected by the National Cancer Center from September, 2010 to June, 2015. Aging genes were downloaded from the Aging Atlas database. Differential express genes between the normal tissue and the cancer tissue were compared. Single factor Cox and Lasso regression were applied to obtain prognostic-related aging genes. Then the signature was constructed, the patients were divided into high-risk group and low-risk group with the median of risk coefficient as the cut-off value. Univariate and multivariate regression were used to identify the independent factor, then Nomogram was constructed. Gene set enrichment analysis (GSEA) software was used for the functional enrichment analysis of key genes. Result 119 differential aging genes and 10 prognostic-related genes were obtained, including 2 tumor suppressor genes(NRG1, IL2RG) and 8 cancer-promoting genes (EIF4EBP1,MMP1, PLAU, MMP13, RAD51, FGF7, DLL3, IGFBP1). The 10-aging-gene signature was constructed by Cox. The prognosis between the high risk and low risk group was significantly differently. The Nomogram showed good performance in predicting the overall survival of breast cancer patient. The GSEA showed the high-risk group was significantly enriched in signal pathways such as cell cycle and homologous recombination. The genes of lowrisk group was significantly enriched in the JAK-STAT signaling pathway, cytokine-receptor-interaction pathway. Conclusion The signature based on aging related genes had a good performance on predicting the prognosis of breast cancer patients.

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    The application value of artificial intelligence computer aided system in benign and malignant thyroid nodules
    YANG Xiaoyun, TIAN Ye, ZHANG Wei, JIANG Jue, WANG Juan, ZHOU Qi
    Journal of General Surgery for Clinicians    2021, 9 (1): 12-.  
    Abstract136)            Save
    Abstract: Objective To explore the diagnostic value of artificial intelligence computer aided system (AI-CAD) in benign and malignant thyroid nodules. Methods To analyzed 473 patients with 517 thyroid nodule in Xi 'an Jiaotong University the second affiliated hospital from June 2019 to December 2019, all nodules were confirmed by pathology, based on AI-CAD, the judgment standard is divided into three groups, the AI score of benign group was 0~0.40, the AI score of suspicious group score was
    0.41~0.60 and the AI score of malignant group was 0.61~1.00. The distribution of scores in each group was observed by boxplot, and the diagnostic accuracy was compared among the three groups with pathological results as the gold standard. Results The diagnostic accuracy rates of benign and malignant thyroid nodules were respectively 88.94%, 69.75% and 84.53%. There was significant difference between groups (P<0.001). Conclusion Artificial intelligence assisted system has high value for the differential diagnosis of benign and malignant thyroid nodules, especially for the determination of benign nodules, which is beneficial to help beginners to improve their confidence in diagnosis.

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    Progress of traditional Chinese and western medicine for wound repair after hemorrhoids surgery
    LI Yikun, GUO Xiutian
    Journal of General Surgery for Clinicians    2022, 10 (4): 31-.  
    Abstract136)            Save

    Due to the particularity of the operation site, the operation of mixed hemorrhoids often adopts open treatment after the operation. The risk of wound contamination is high. The poor growth of wound granulation tissue, edema, and slow wound healing are common problems that anorectal surgeons have when treating patients. In recent years, the understanding of related mechanisms of wound repair has been deepened, especially the application of new materials and technologies, providing more clinical options. Traditional Chinese medicine has the advantages of precise curative effect, high safety and low price in the treatment of wounds, and is widely used in clinical practice. This paper reviews the research progress of traditional Chinese and western medicine on wound repair.

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