Abstract: Abstract: Objective To analyze the efficacy and safety of endoscopic retrograde appendicitis treatment for acute uncomplicated appendicitis. Methods The subjects of this study were 80 patients with acute uncomplicated appendicitis admitted to Foshan Women and Children Hospital from July 2018 to May 2020. They were divided into conventional groups (laparoscopic appendectomy) according to different treatment methods. Study group (retrograde endoscopic appendicitis treatment), 40 cases in
each group. Compare the levels of serum tumor necrosis factor (TNF-α), C-reactive protein (CRP), and interleukin (IL) -6 before and after treatment in the two groups, as well as the time in bed, hospitalization time, operation time, and incidence of complications , To explore the efficacy and safety of endoscopic retrograde appendicitis treatment. Results Before treatment, the levels of TNF-α, CRP and IL-6 of the two groups were not statistically different (P>0.05). After treatment, the levels of TNF-α, CRP,
and IL-6 in the study group were lower than those in the conventional group (P<0.05); the bed time, hospital stay, and operation time of the study group were shorter than those in the conventional group (P<0.05); The complication rate of the group was 2.50%, which was lower than that of the conventional group (15.00%,P<0.05). Conclusion The use of endoscopic retrograde appendicitis treatment for acute uncomplicated appendicitis is less invasive, can reduce surgical stress response, is very conducive to the rapid recovery of patients after surgery, and has good safety.