Abstract:

Objective To explore the impact of zhenqi fuzheng granules combined with probiotics on intestinal mucosal barrier function in patients undergoing nutritional support following early gastric cancer surgery. Method From August 2021 to August 2023, 100 patients with early gastric cancer in Huai'an First Hospital Affiliated to Nanjing Medical University were selected and randomly divided into two groups, 50 cases in each group. The control group was treated with early postoperative enteral nutrition combined with probiotics, while the observation group was treated with zhenqi fuzheng granules based on this. The postoperative recovery indexes of the two groups were compared, and the changes of nutritional status and intestinal mucosal barrier function before and after intervention were compared. Result The recovery time of bowel sounds, the first exhaust time and the hospitalization time of the observation group were shorter than those of the control group, the difference was significant (P ＜ 0.01), but there was no significant difference in the indwelling time of catheter and the first ambulation time between the two groups (P ＞ 0.05). Before intervention, there was no significant difference in the levels of nutritional indicators and intestinal mucosal barrier function related indicators between the two groups (P ＞ 0.05). After the intervention, the nutritional index levels of the two groups were improved, and the levels of transferrin, albumin and prealbumin in the observation group were higher than those in the control group; The levels of intestinal mucosal barrier function related indicators in the two groups were improved, and the levels of intestinal fatty acid binding protein, procalcitonin and D-lactic acid in the observation group were lower than those in the control group, with significant differences (P ＜ 0.001). Conclusion Zhenqi fuzheng granules combined with  probiotics has positive significance on nutrition and intestinal mucosal barrier function in patients with early gastric cancer after operation.

Key words: Zhenqi fuzheng granules, Probiotics, Enteral nutrition, Early gastric cancer, Intestinal mucosa