Abstract:

Objective To investigate the effect of lung protective ventilation strategy on oxygenation

function and serum inflammatory mediators in elderly patients undergoing laparoscopic colorectal

cancer surgery. Methods Seventy-six elderly patients undergoing laparoscopic colorectal cancer surgery

in Cancer Hospital of Nantong University from March 2020 to April 2021 were randomly divided into

observation group and control group, 38 cases in each group. Patients in the observation group were

treated with pulmonary protective ventilation strategy, and patients in the control group were treated with

conventional positive pressure ventilation strategy. The changes of parameters of oxygenation function

and serum inflammatory mediators during operation, as well as the incidence of complications, were

compared between the two groups. Results In the data comparison of oxygenation function between the two groups, the observation group was significantly better than the control group(P ＜ 0.05); In the

comparison of serum inflammatory mediators, the data of observation group was better than control

group(P ＜ 0.05); The incidence of complications in observation group was significantly lower than that

in control group(P ＜ 0.05). Conclusion Lung protective strategy has a significant effect on the clinical

treatment of elderly patients undergoing laparoscopic surgery for colorectal cancer, with high safety.

Key words: Laparoscopic colorectal surgery, Lung protective ventilation strategy, Oxygenation function, Serum inflammatory mediators, Elderly