Abstract:

Objective To investigate the effect of single incision laparoscopic radical resection of colon cancer on postoperative immune ability and stress response in elderly patients with colorectal cancer. Method A total of 68 patients with colorectal cancer who received single incision laparoscopic treatment in the second geriatric hospital of Wuxi from May 2022 to May 2025 were selected and randomly divided into two groups, 34 cases in each group. The conventional group received conventional open surgery, and the experimental group received single incision laparoscopic radical resection of colon cancer. The physical signs, cellular immune function and stress response index levels of the two groups at different time points were compared. Result There were no signifi cant differences in heart rate, mean arterial pressure, pulse oxygen saturation (SpO2) and respiratory rate between the two groups before anesthesia, when anesthesia was successful and 72 hours after operation (P ＞ 0.05). At the end of operation and 24 hours after operation, the heart rate of the experimental group was lower than that of the conventional group, and the mean arterial pressure, SpO2 and respiratory rate of the experimental group were higher than those of the conventional group, with significant differences (P ＜ 0.05). There were no signifi cant diff erences in the percentages of CD3+T cells, CD4+T cells, cortisol and interleukin-6 between the two groups before and after anesthesia (P ＞ 0.05). At the end of operation, 24 hours and 72 hours after operation, the percentages of CD3+ T cells and CD4+ T cells in the experimental group were higher than those in the conventional group, and the levels of cortisol and interleukin-6 were lower than those in the conventional group, with significant differences (P ＜ 0.05). Conclusion Compared with traditional open surgery, single incision laparoscopic radical resection of colon cancer has less impact on elderly patients with colorectal cancer, can better stabilize the immune ability of patients, and the stress response is mild.

Key words: Colorectal cancer, Single-incision laparoscopic radical resection of colon cancer, Immunity, Stress response