Abstract:

Objective To explore the diagnostic value of red blood cell distribution width (RDW) and serum neuron specific enolase (NSE) in colon malignant tumors. Method 154 cases of patients with a clear clinical diagnosis of colon cancer (colon cancer group) and 150 cases of healthy people (control group) were selected from The Fifth Affiliated Hospital of Xinjiang Medical University from 2018 January to 2021 January, and the blood routine indexes of the two groups were compared, including red blood cell (RBC), platelet (PLT), lymphocyte ratio (LY%), RDW and tumor We compared the levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA-125), carbohydrate antigen 125 (CA-199), and NSE in colon cancer patients with diff erent clinical data. RDW and NSE levels in colon cancer patients with diff erent clinical data. The diagnostic value of RDW, NSE, CEA and CA19-9 for colon cancer was analyzed by applying receiver operating characteristic (ROC) curve. Result RBC, LY%, RDW in blood routine, NSE, CEA, CA125, CA19-9 in tumor markers were statistically significant compared with the control group, and there was a significant correlation between the positive expression of serum RDW and the pathological stage of the tumor and whether lymph node metastasis had occurred, and it was concluded that RDW, NSE and its combination with CEA and CA19-9 had high diagnostic value in colon cancer by ROC curve. The ROC curve showed that RDW, NSE and their combination with CEA and CA19-9 had high diagnostic value for colon cancer. Conclusion Elevated levels of RDW and NSE may have a close relationship with the development of colon cancer, and both of them may become an important indicator for the early diagnosis and judgment of colon cancer.

Key words: Colon cancer, Red blood cell distribution width, Serum neuron-specific enolase, Tumor markers, Early diagnosis