Abstract:

Objective To observe the effect of using ceftriaxone combined with metronidazole for anti-infective treatment of patients with acute suppurative appendicitis during the perioperative period. Method A retrospective analysis was conducted on the clinical data of 80 patients with acute suppurative appendicitis who underwent routine postoperative anti-infective treatment (tranexamic acid+metronidazole) at Guilin Integrated Traditional Chinese and Western Medicine Hospital from May 2023 to May 2024 (control group). The clinical data of 80 patients with acute suppurative appendicitis who underwent postoperative anti-infective treatment with ceftriaxone+metronidazole (observation group) were also reviewed during the same period. Statistics were conducted on the incidence of adverse reactions, levels of inflammatory factors before and after 5d of treatment, body temperature, and length of hospital stay for two groups. Result On the day of surgery, there was no significant difference in body temperature levels between the two groups of patients (P ＞ 0.05). On postoperative day 1, 3, and 5, the temperature levels of patients in the observation group were lower than those in the control group, and the hospitalization time was shorter than that in the control group, with significant differences (P ＜ 0.001). Before treatment, there was no significant difference in the levels of C-reactive protein, tumor necrosis factor alpha, and interleukin-6 between the two groups of patients (P ＞ 0.05). After treatment, the levels of inflammatory factors in both groups of patients improved compared to before treatment, and the levels of C-reactive protein, tumor necrosis factor alpha, and interleukin-6 in the observation group were significantly lower than those in the control group (P ＜ 0.01). The incidence of postoperative adverse reactions in the observation group was lower than that in the control group (3.75% vs. 12.50%), and the difference was significant (P ＜ 0.05). Conclusion The combination of ceftriaxone and metronidazole for anti-infective treatment of patients with acute suppurative appendicitis during the perioperative period can reduce the risk of postoperative adverse reactions, lower levels of inflammatory factors, and shorten hospital stay.

Key words: Metronidazole, Cefatriaxone, Acute suppurative appendicitis, Perioperative period, Anti-infection