Abstract:

Objective To explore the effect of laparoscopic D2 radical resection for elderly patients with locally advanced gastric cancer. Method 86 elderly patients with locally advanced gastric cancer admitted to Jinhua Hospital affiliated with Wenzhou Medical University from October 2022 to November 2024 were selected and divided into two groups using the coin toss method, with 43 patients in each group. The reference group underwent open D2 radical surgery for gastric cancer, while the study group underwent laparoscopic D2 radical surgery for gastric cancer. Observe and compare the levels of inflammatory factors, stress response indicators, immune function, and postoperative complications between two groups of patients before and after treatment. Result Before treatment, there was no significant difference in the levels of inflammatory factors, stress response indicators, and immune function between the two groups of patients (P ＞ 0.05). After treatment, the levels of inflammatory factors and stress response indicators in the study group were better than those in the control group, and the percentages and ratios of CD8+T cells and CD4+T cells were higher than those in the control group, with significant differences (P ＜ 0.05). The total incidence of postoperative complications in the study group was 2.33%, significantly lower than that in the control group (20.93%), with a significant difference (P=0.007). Conclusion Laparoscopic D2 radical resection for elderly patients with locally advanced gastric cancer can effectively improve the levels of inflammatory factors and stress response indicators, enhance the patient's immune function, and reduce the risk of postoperative complications.

Key words: Locally advanced gastric cancer, Laparoscopic D2 radical resection for gastric cancer, Infl ammatory factors, Stress response