Abstract:

Objective To investigate the clinical effi cacy and safety of endoscopic mucosal dissection in the treatment of early colorectal cancer and precancerous lesions. Method Sixty patients with early colorectal cancer and precancerous lesions admitted to Nanjing Anal Tai Traditional Chinese Medicine Hospital from January 2022 to December 2023 were randomly divided into two groups using a random number table. The control group (n=30) underwent endoscopic mucosal resection, while the observation group (n=30) underwent endoscopic submucosal dissection. The perioperative indicators, levels of infl ammatory factors, stress response indicators, and biochemical indicators before and after surgery were compared between the two groups of patients. Result The surgical time, re-covery time, analgesia time, hospitalization time, and incision length of the observation group were all shorter than those of the control group, and the intraoperative blood loss was less than that of the control group, with signifi cant

differences (P ＜ 0.05). Before surgery, there were no signifi cant diff erences in the levels of infl ammatory factors, stress response indicators, and biochemical indicators between the two groups of patients (P ＞ 0.05). After surgery, the levels of infl ammatory factors and stress response indicators in the observation group were signifi cantly low-er than those in the control group (P ＜ 0.05); After surgery, the levels of motilin, somatostatin, and vascular cell adhesion molecule-1 in the observation group were signifi cantly lower than those in the control group (P ＜ 0.05). Conclusion Early stage colon cancer and precancerous lesions can be treated with submucosal dissection under di-gestive endoscopy to improve their infl ammatory factors and stress response.

Key words: Endoscopic submucosal dissection, Precancerous lesions, Degree of stress response, Infl ammatory factors