Abstract:

Objective To explore the anesthetic effect of ketamine combined with remifentanil on appendectomy and its impact on postoperative pain and adverse reactions in patients. Method 102 patients who underwent appendectomy at the Huai'an First People's Hospital Branch from January 2023 to March 2024 were selected and randomly divided into an observation group (n=51) and a control group (n=51) according to the principle of random number table. Both groups adopted the same anesthesia induction protocol, with the control group receiving remifentanil anesthesia during surgery and the observation group receiving a combination of ketamine and remifentanil anesthesia during surgery. Result Compare the perioperative vital signs, postoperative pain, and incidence of adverse reactions between two groups of patients. There was no signifi cant diff erence in heart rate and mean arterial pressure between the two groups of patients when they entered the operating room (P ＞ 0.05); The heart rate and mean arterial pressure at 1 minute and 5 minutes of anesthesia were lower than those at the time of entering the operating room (P ＜ 0.05), while there was no signifi cant diff erence at the end of the operation compared to entering the operating room (P ＞ 0.05). The heart rate and mean arterial pressure of the observation group patients were signifi cantly higher than those of the control group at 1 minute and 5 minutes of anesthesia (P ＜ 0.05). The VAS scores of the observation group were signifi cantly lower than those of the control group at 4, 8, and 12 hours after surgery (P ＜ 0.05), while there was no signifi cant diff erence in VAS scores between the two groups at 24 hours after surgery (P ＞ 0.05). There was no signifi cant diff erence in the occurrence of adverse reactions between the two groups of patients (P ＞ 0.05). Conclusion For patients undergoing appendectomy, the anesthesia eff ect of using ketamine combined with remifentanil is satisfactory, with mild postoperative pain and a lower incidence of adverse reactions.

Key words: Appendectomy, Ketamine, Remifentanil, Postoperative pain, Adverse reactions