Abstract:

Objective To investigate the effects of propofol combined with isoflurane inhalation anesthesia on stress response and pain level in patients undergoing neck thyroidectomy for thyroid cancer. Method Eighty patients with thyroid cancer who underwent elective cervical thyroidectomy at the branch of Huai'an First People's Hospital from January 2022 to January 2024 were selected and randomly divided into an observation group and a control group, with 40 patients in each group, using a random number table method. The control group received sufentanil combined with propofol anesthesia induction, while propofol combined with remifentanil was used to maintain anesthesia during surgery. The observation group received isofl urane inhalation to maintain anesthesia based on anesthesia induction and maintenance in the control group. Compare the stress responses of two groups of patients before surgery, 5 minutes after anesthesia, and at the end of surgery, as well as the degree of pain at diff erent time points after surgery. Result The levels of cortisol and C-reactive protein in both groups of patients increased 5 minutes after anesthesia and at the end of surgery compared to before surgery. However, the levels of cortisol and C-reactive protein in the postoperative observation group were lower than those in the control group, and the diff erences were signifi cant (P ＜ 0.05). After 2 hours postoperatively, the VAS scores of both groups of patients increased signifi cantly compared to 30 minutes postoperatively (P ＜ 0.05). At 4 and 12 hours postoperatively, the VAS scores of both groups of patients decreased signifi cantly compared to 2 hours postoperatively (P ＜ 0.05). The VAS scores of the observation group were signifi cantly lower than those of the control group at 30 minutes, 2 hours, and 4 hours after surgery (P ＜ 0.05), while there was no signifi cant diff erence in VAS scores between the two groups at 12 hours after surgery (P ＞ 0.05). Conclusion For thyroid cancer patients undergoing cervical thyroidectomy, propofol combined with isofl urane inhalation anesthesia can signifi cantly alleviate stress reactions and reduce postoperative pain.

Key words: Thyroid cancer, Cervical resection surgery, Propofol, Isoflurane inhalation anesthesia, Stress response