Abstract:

Objective To explore the preventive effect of sufentanil on breakthrough pain after discontinuation of remifentanil in laparoscopic appendectomy. Method Seventy patients who underwent laparoscopic appendectomy and received remifentanil anesthesia at Jiaozhou Hospital Affiliated to Tongji University from November 2022 to May 2023 were selected. They were randomly divided into two groups, with 35 patients in each group. The study group and the control group were treated with different drugs to prevent breakthrough pain after remifentanil anesthesia. The study group received intravenous injection of 0.1mg/kg sufentanil 30 minutes

before skin suture, while the control group received intravenous injection of the same dose of physiological saline. Observe the pulse oxygen saturation (SpO2), heart rate, systolic blood pressure, diastolic blood pressure, and pain score of two groups of patients 5 minutes (T1), 15 minutes (T2), and 30 minutes (T3) after surgery, and record the postoperative complications such as nausea, vomiting, and irritability in both groups of patients. Result The pain scores of the study group at T1, T2, and T3 were significantly lower than those of the control group, while the heart rate, systolic blood pressure, and diastolic blood pressure were significantly lower than those of the control group, with significant differences (P ＜ 0.05). There was no significant difference in SpO2 levels between the two groups at different time points (P ＞ 0.05), and there was no significant difference in postoperative complications such as nausea, vomiting, irritability, and respiratory depression (P ＞ 0.05). Conclusion Intravenous injection of

0.1mg/kg sufentanil 30 minutes before the end of surgery can effectively prevent postoperative breakthrough pain after remifentanil anesthesia, with good analgesic effect and no impact on awakening quality.

Key words: Laparoscope, Sufentanil, Remifentanil, Breakthrough pain