Abstract:

Objective To colorectal cancer patients for laparoscopic colorectal cancer radical, discuss the therapeutic effect and its influence on the immune function, serum inflammatory factors. Method Retrospective analysis the clinical data of 80 patients with colorectal cancer, according to the operation method of divided into open and laparoscopic group, open colorectal surgery treatment group received laparotomy, a total of 40 cases, treated by laparoscopic colorectal cancer radical laparoscopic group, a total of 40 cases. Compared to two groups of immune function in patients with [cellular immune index (CD3+, CD4+, CD8+ , CD4+/CD8+), humoral immune index (IgA, IgM and IgG)], serum inflammatory factors [serum tumor necrosis factor alpha (TNF alpha), interleukin 6 (IL-6), C reactive protein (CRP)] and complications. Result The laparoscopic group after treatment of CD3+, CD4+ group and CD4+/CD8+is significantly higher than laparotomy, CD8+, significantly lower than laparotomy group, the differences are significant (P ＜ 0.05). After treatment, there was no significant difference in IgA and IgG levels between the laparoscopic group and the open group (P ＞ 0.05), but IgM levels were higher than those in the open group, with a significant difference (P ＜ 0.05). After treatment, the TNF-α of both groups of patients, the levels of IL-6 and CRP were significantly increased compared to before treatment, with significant differences (P ＜ 0.05). The incidence of complications in the laparoscopic group was significantly lower than that in the open group (P ＜ 0.05). Conclusion For patients with colorectal cancer can reduce inflammation in patients with laparoscopic colorectal cancer radical stress reaction, on the immune function of patients with smaller, less complications.

Key words: Laparoscopic colorectal cancer radical, Colorectal cancer, Serum levels of inflammatory cytokines, Effect