Abstract:

As an important digestive organ of human body, the intestinal microenvironment is a very complex environment, which plays an important role in regulating intestinal metabolism, immunity and protecting intestinal epithelial barrier. Tumor microenvironment (TME) of intestinal tumors is highly complex, which is composed of stromal cells, tumor cells, immune cells, fibroblasts and microorganisms, and deeply affects the occurrence, development and metastasis of tumors. This paper summarizes the relationship between immune cells (T cells, macrophages, neutrophils, natural killer cells) in TME and tumor cells, and analyzes the role of immune cells in TME in tumor (anti-tumor, promoting tumor growth, etc.) in order to fully understand the relationship between immune cells and tumors in TME and provide new strategies for clinical treatment of colorectal cancer patients.

Key words: Colorectal cancer, Immune cell, Intestines, Macrophage, Microenvironment