Abstract:

Objective To investigate the effect of neoadjuvant chemotherapy combined with laparoscopic radical resection of rectal cancer. Method 60 patients with rectal cancer from January 2018 to January 2020 were selected,30 patients in the control group received laparoscopic radical resection of colorectal cancer, and did not receive neoadjuvant chemotherapy before surgery. 30 patients in the observation group received neoadjuvant chemotherapy before laparoscopic radical resection of colorectal cancer, the resection effect and prognosis were compared between the two groups. Result The positive rate of peripheral incisal margin, the rate of abdominal implant metastasis, the rate of anastomotic recurrence and the rate of distant metastasis in the observation group were lower than those in the control group, and the progression-free survival and total survival were significantly higher than those in the control group (P ＜ 0.05); There was no significant difference in the levels of carcinoembryonic antigen, CA19-9 and CA242 between the two groups before treatment (P ＞ 0.05). The levels of carcinoembryonic antigen, CA19-9 and CA242 in the observation group were lower than those in the control group after treatment (P ＜ 0.05).Conclusion Neoadjuvant chemotherapy before laparoscopic radical resection of colorectal cancer can improve the resection effect, prolong the survival time of patients, and reduce the expression level of tumor markers.

Key words: Neoadjuvant chemotherapy, Laparoscopic radical resection of colorectal cancer, Colorectal cancer, Prognosis