Abstract:

Objective To investigate the effect of propofol combined with etomidate anesthesia induction on hemodynamics and inflammatory factors in patients undergoing laparoscopic cholecystectomy. Method 80 cases of laparoscopic cholecystectomy patients admitted to Qinghai Tibetan Hospital from January 2020 to January 2022 were selected and divided into two groups with 40 cases each according to the method of numerical random table. The control group was anesthetized with propofol, and the observation group was anesthetized with propofol and etomidate. The hemodynamic changes at different time points during the operation were compared between the two groups, the changes of inflammatory factors were detected in the two groups, and the adverse reactions of anesthetic drugs were evaluated. Result After induction, the heart rate and mean arterial pressure in the observation group were significantly higher than those in the control group (P ＜ 0.05); the level of inflammatory indicators in the

observation group was lower than that in the control group on the first day after operation, and the recovery time of eye opening, catheter removal and directional force was shorter than that in the control group, with significant differences (P ＜ 0.05). There was no significant difference in the incidence of adverse reaction to anesthesia between the two groups (P ＞ 0.05). Conclusion Propofol combined with etomidate anesthesia induction for laparoscopic cholecystectomy has good effect, stable hemodynamics and high safety.

Key words: Propofol, Etomidate, Induction of anesthesia, Laparoscopic cholecystectomy, Hemodynamics, Inflammatory factors