Abstract:

Objective To explore the application of multiple serum tumor markers in the diagnosis of primary liver cancer. Method 105 patients with primary liver cancer, benign liver disease and non liver disease who were treated in Wuzhou Workers' Hospital from January 2019 to December 2021 were selected, and 35 patients were included in the liver cancer group, the benign liver disease group and the control group respectively according to different diseases. Detect the abnormal prothrombin (DCP), alpha fetoprotein (AFP) α- L-fucosylase(AFU), carbohydrate antigen 19-9 (CA19-9), and evaluate the diagnostic value of the above indicators alone and in

combination. Result The DCP, AFP, AFU, CA19-9 water of patients with liver cancer were higher than those of the other two groups on average, and there was significant difference between the two groups (P<0.05). According to the analysis of the working characteristic curve of the subjects, the best diagnostic thresholds of serum DCP, AFP, AFU and CA19-9 were 39.38mAU/ml, 48.35μg/L, 25.93U/L and 50.54U/ml, respectively. The Jordan index of the tandem test of AFP+AFU and DCP+AFP+AFU was the largest, 0.757. Conclusion Among serum DCP, AFP, AFU and CA19-9, AFP combined with AFU has the highest diagnostic efficacy.

Key words: Primary liver cancer, Alpha-fetoprotein, α-L-fucosidase, Joint testing