Abstract:

Objective To investigate the value and safety of ultrasound-guided radiofrequency ablation in thyroid carcinoma. Method 78 patients with thyroid cancer treated in Nanjing Gaochun People's Hospital from November 2018 to June 2021 were selected and divided into the study group and the control group with 39 cases in each group according to the simple random number table method. The control group was treated with ultrasoundguided microwave ablation, and the study group was treated with ultrasound-guided radiofrequency ablation of thyroid gland. The tumor control effect, the level of inflammatory stress indexes before and after operation and the incidence of complications were analyzed. Result The lesion volume of the two groups decreased at 1 week, 1 month, 3 months and 6 months after operation (P ＜ 0.05), but there was no significant difference between the two groups at different time after operation (P ＞ 0.05). One day after operation, the levels of serum interleukin (IL)-6, tumor necrosis factor (TNF)-α and malondialdehyde (MDA) in the two groups were higher than those before operation, and the levels of superoxide dismutase (SOD) were lower than those before operation (P ＜ 0.05), but there was no significant difference between the study group and the control group (P ＞ 0.05). The incidence of fever (7.69%) and pain (5.13%) in the study group was lower than that in the control group (25.64% and 20.51%, respectively)(P ＜ 0.05). Conclusion Ultrasound-guided radiofrequency ablation is as effective as microwave ablation in the treatment of thyroid cancer. The inflammatory stress caused by operation is mild, and can reduce the incidence of fever and pain.

Key words: Ultrasound guided, Radiofrequency ablation, Thyroid cancer, Tumor control effect