Abstract:

Objective To investigate the diagnostic value of leukocyte count and serum C reactive protein levels in the onset of acute appendicitis and changes in the condition. Method 150 patients with acute appendicitis treated in Guihang Guiyang Hospital from October 2018 to June 2021 were selected as the observation group, including 63 cases of simple appendicitis, 52 cases of suppurative appendicitis and 35 cases of gangrenous appendicitis according to the pathological type. 50 patients with abdominal pain suspected of appendicitis were selected as the control group. The leukocyte count and serum C reactive protein level of the two groups were compared, and the leukocyte count and serum C reactive protein level of patients with acute appendicitis of different pathological types were compared. The diagnostic efficacy of leukocyte count and serum C reactive protein level for acute appendicitis was calculated, and the receiver operating characteristic curve (ROC curve) was drawn. Result The leukocyte count and serum C reactive protein level in the observation group were significantly higher than those in the control group (P ＜ 0.01). The leukocyte count and serum C reactive protein level in patients with gangrenous appendicitis were significantly higher than those in patients with suppurative appendicitis and simple appendicitis. The leukocyte count and serum C reactive protein level in patients with suppurative appendicitis were significantly higher than those in patients with simple appendicitis (P ＜ 0.01). ROC curve analysis showed that the area under ROC curve (0.8952) of leukocyte count ＞ 10×109/L combined with C reactive protein ＞ 50mg/L was the highest in the diagnosis of acute appendicitis, which was significantly higher than that of other diagnostic methods (P＜ 0.05). Conclusion Leukocyte count and serum C reactive protein levels in patients with acute appendicitis are significantly increased and are closely related to the change of condition, which has certain diagnostic value for the onset and evaluation of acute appendicitis, while combined diagnosis can improve diagnostic efficacy and have high clinical significance.

Key words: Leukocyte count, C reactive protein, Acute appendicitis, Diagnostic value