Abstract:

Abstract: Objective Study application of M. O. I. S.T. theory in the clinical practice of stage 3 and stage 4 stress injury. Methods A total of 64 patients with stage 3 and stage 4 stress injury who were hospitalized in The Fourth Affiliated Hospital of Guangzhou Medical University from July 2019 to October 2019 were randomly divided into observation group and control group (32 cases in each group) . The control group was treated with vacuum-assisted closure (VAC) and the observation group was treated with VAC combined with continuous micro-oxygen therapy. Results After intervention, the wound shrinkage rate of the observation group was higher than that of the control group (P<0.05). After intervention, the observation group's granulation tissue coverage rate increased, the wound healing rate increased, the wound pain score decreased, the wound bacterial culture rate decreased, the difference was statistically significant (P<0.05) ; After intervention, there were significant differences in wound pH,CD34+T Cell and proliferating cell nuclear antigen (P<0.05). Conclusion VAC combined with microoxygen therapy can accelerate wound area reduction, promote granulation tissue growth and wound healing, reduce wound pain, and reduce wound bacterial residue in patients with pressure ulcer of stage 3 and 4, to improve the pH of the wound and the tissue immunology.

Key words: Vacuum-assisted closure, Continuous microoxygenation, Pressure injury, Wound reduction, Granulation tissue coverage