关键词: 慢性创面, 中药贴敷, 三氧, 氧化应激, 炎性因子

Abstract:

Objective To study the clinical curative effect of trioxygen combined with traditional Chinese medicine sticking for the treatment of the patients with chronic wounds. Method 80 patients with chronic wounds in Jiaozhou Hospital of Tongji University from January 2021 to September 2022 were randomly divided into two groups according to the random number table method. Forty cases in the control group were treated with the method of routine debridement, anti-infection and dressing change. Forty cases in the study group were treated with the method of trioxygen combined with traditional Chinese medicine stricking on the basis of routine curative method treatment with a curative time 3 weeks in these two groups. The wound healing time, symptom score, clinical

efficacy, inflammatory factors and oxidative stress indexes of the two groups were observed and the treatment safety of the two groups was also evaluated. Result The total effective rate in the study group (95.00%) was higher than those of the control group (72.50%), but the wound healing time in the study group was shorter than those of the control group (P ＜ 0.05). After 3 weeks of treatment, The levels of various parameters including edema, pain, hemorrhage, secretion score, serum interleukin-1, interleukin -6, tumor necrosis factor-α, malondialdehyde, advanced oxidation protein products were significantly decreased, especially in the study group , the level of superoxide dismutase was significantly higher in the study group (P ＜ 0.05). There were no adverse reactions and abnormal laboratory indexes in both groups. Conclusion Trioxygen combined with traditional Chinese medicine was effective in treating chronic wounds and could effectively promote wound healing, relieve symptoms, inhibit

inflammatory reaction and reduce oxidative stress.

Key words: Chronic wound, Traditional Chinese medicine sticking, Trioxygen, Oxidative stress, Inflammatory factor