Abstract:

Objective To analyze the effect of ultrasound-guided regional block anesthesia(USRA) combined with general anesthesia(GA) on the stress and pain levels of patients undergoing laparoscopic radical resection of colon cancer. Method A retrospective analysis was conducted on 200 patients who underwent laparoscopic radical resection of colon cancer in Beijing Jiangong Hospital from December 2022 to December 2024. They were divided into two groups according to different anesthesia regimens, with 100 cases in each group. The control group was given GA, and the observation group was given USRA-GA. The levels of norepinephrine, angiotensin Ⅱ , cortisol, postoperative pain and adverse reactions in the two groups were analyzed. Result Before operation, there was no significant difference in the levels of angiotensin Ⅱ, norepinephrine and cortisol between the two groups (P＞0.05). At 24 hours after operation, the levels of stress response indexes in the two groups were increased compared with those before operation (P ＜ 0.05), and the levels of angiotensin Ⅱ , norepinephrine and cortisol in the observation group were lower than those in the control group, with significant differences (P ＜ 0.001). The visual analogue scale scores at 6h, 12h and 24h after operation in the observation group were significantly lower than those in the  control group (P ＜ 0.001). There was no significant difference in the total incidence of adverse events between the two groups (P ＞ 0.05). Conclusion USRA-GA helps reduce postoperative stress response and pain level in patients undergoing laparoscopic radical resection of colon cancer, and does not increase the risk of adverse events.

Key words: Ultrasound-guided regional block anesthesia, General anesthesia, Laparoscopic radical resection , of colon cancer, Stress response, Postoperative pain