Abstract:

Objective To explore the value of combined detection of serum tumor markers alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA125) in the diagnosis of hepatocellular carcinoma. Method 56 patients with hepatocellular carcinoma admitted to Suqian Integrated Traditional Chinese and Western Medicine Hospital from January 2023 to November 2024 were selected as the liver cancer group, 56 patients with benign liver disease (chronic hepatitis and cirrhosis) were selected as the benign liver disease group, and 56 healthy individuals who underwent physical examinations during the same period were selected as the control group. Detect the levels of serum tumor markers AFP, CEA, and CA125 in three groups, and evaluate the diagnostic efficacy of single and combined detection of AFP, CEA, and CA125. Result The levels of AFP, CEA, and CA125 in the liver cancer group were higher than those in the benign liver disease group and the control group (P ＜ 0.05); The working characteristic curve of the subjects showed that the area under the curve for the combined detection of AFP, CEA, and CA125 was 0.967, with a sensitivity of 91.07% and a specificity of 93.75%, all higher than the detection of AFP, CEA, and CA125 alone. Conclusion The combined detection of AFP, CEA, and CA125 can significantly improve the diagnostic efficacy of hepatocellular carcinoma. Compared with single biomarker detection, the combined detection has higher sensitivity and specificity.

Key words: Serum tumor markers, Alpha fetoprotein, Carcinoembryonic antigen, Carbohydrate antigen 125, Hepatocellular carcinoma, Diagnostic value