Abstract:

Objective To investigate the eff ects of laparoscopic cholecystectomy on the levels of infl ammatory factors, pain scores, and incidence of complications in patients with acute cholecystitis caused by stones. Method Eighty patients with acute calculous cholecystitis who visited Shantou Chaonan Minsheng Hospital from June 2023 to June 2024 were randomly divided into a control group (small incision cholecystectomy) and a study group (laparoscopic cholecystectomy) using a random number table, with 40 patients in each group. Compare the levels of infl ammatory factors, pain scores, oxidative stress indicators, and incidence of complications between two groups. Result Before surgery, there was no signifi cant diff erence in the levels of interleukin-6, interleukin-8, C-reactive protein, tumor necrosis factor - α, as well as serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels between the two groups of patients (P ＞ 0.05). After surgery, the levels of interleukin-6, interleukin-8, C-reactive protein, tumor necrosis factor - α, and serum MDA in the study group were lower than those in the control group, but the level of SOD was higher than that in the control group, and the diff erences were signifi cant (P ＜ 0.05). At 12 hours, 1 day, and 3 days after surgery, the pain scores of patients in the study group were signifi cantly lower than those in the control group (P ＜ 0.05). The total incidence of postoperative complications in the study group (3.33%) was lower than that in the control group (13.33%), and the diff erence was signifi cant (P ＜ 0.05). Conclusion Laparoscopic cholecystectomy for the treatment of acute calculous cholecystitis can inhibit the body's inflammatory response and postoperative pain, reduce surgical stress response, and lower the risk of complications. 

Key words: Acute calculous cholecystitis, Laparoscope, Cholecystectomy, Infl ammatory factors, Pain score, Complication