关键词: 粪菌移植, 慢性功能性便秘, 肠道菌群, 肠道动力

Abstract:

Objective To study the effect of fecal bacteria transplantation on intestinal flora and intestinal motility in patients with chronic functional constipation. Method A total of 30 patients diagnosed as chronic functional constipation in the Department of Gastroenterology of the Sixth Affiliated Hospital of South China University of Technology from January 2020 to December 2020 were included. The transplanted fecal bacteria were prepared by hand, the distribution of intestinal flora, gastrointestinal motility and quality of life before and after fecal bacteria transplantation treatment were compared. Result After fecal bacteria transplantation, intestinal flora richness (t=4.382, P ＜ 0.001), Shannon-Wiener index (t=2.948, P=0.006) and maximum Shannon-Wiener index (t=3.213, P=0.003) were significantly increased. However, there was no significant improvement in the uniformity of intestinal flora before and after treatment (t=1.303, P=0.203). The mean amplitude (t=21.283, P ＜ 0.01) and mean frequency (t=4.584, P ＜ 0.001) of preprandial electrointestinogram were significantly improved after fecal bacteria transplantation. There also showed statistically significant improvements in mean postprandial amplitude (t=12.394, P ＜ 0.001) and mean frequency (t=2.945, P=0.006). The gastrointestinal quality of life index (GIQLI) of gastrointestinal quality of life was (79.39±16.43) before treatment, and (120.48±22.14) after 1 month oftreatment, the difference was statistically significant compared with that before treatment (t=23.483, P ＜ 0.001). Conclusion Fecal bacteria transplantation can effectively improve the intestinal flora richness of patients with chronic functional constipation, improve intestinal motility, and improve the quality of life of patients, which is worthy of clinical promotion.

Key words: Fecal bacteria transplantation, Chronic functional constipation, Intestinal flora, Intestinal motility