临床普外科电子杂志 ›› 2022, Vol. 10 ›› Issue (3): 161-.

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白细胞计数与C 反应蛋白水平诊断急性阑尾炎的价值研究

  

  1. 贵航贵阳医院 胃肠外科,贵州 贵阳 550006
  • 出版日期:2022-07-01 发布日期:2022-10-25

Diagnostic value of leukocyte count and C reactive protein levels in acute appendicitis

  1. Gastrointestinal Surgery Department of Guihang Guiyang Hospital, Guizhou Guiyang 550006, China
  • Online:2022-07-01 Published:2022-10-25

摘要:

目的 研究白细胞计数与血清C 反应蛋白水平在急性阑尾炎发病及病情变化中诊断价值。方法选取贵航贵阳医院2018 年10 月至2021 年6 月收治的急性阑尾炎患者150 例作为观察组,其中根据病理类型分为单纯性阑尾炎63 例、化脓性阑尾炎52 例、坏疽性阑尾炎35 例,同期选取经诊断后非阑尾炎的腹痛患者50 例作为对照组。比较两组研究对象的白细胞计数和血清C 反应蛋白水平,同时比较不同病理类型急性阑尾炎患者的白细胞计数和血清C 反应蛋白水平。计算白细胞计数和血清C 反应蛋白水平对急性阑尾炎的诊断效能,并绘制受试者操作特征曲线(receiver operating characteristic curve,ROC 曲线)。结果 观察组患者的白细胞计数和血清C 反应蛋白水平均明显高于对照组,差异具有显著性(P < 0.01)。坏疽性阑尾炎患者的白细胞计数和血清C 反应蛋白水平明显高于化脓性阑尾炎和单纯性阑尾炎患者,化脓性阑尾炎患者的白细胞计数和血清C反应蛋白水平明显高于单纯性阑尾炎患者,三组间比较差异具有显著性(P < 0.01)。ROC 曲线分析显示,白细胞计数> 10×109/L 联合C 反应蛋白> 50mg/L 诊断急性阑尾炎的ROC 曲线下面积最高,为0.8952,明显高于其他诊断方法(P < 0.05)。结论 急性阑尾炎患者白细胞计数和血清C 反应蛋白水平明显升高,且与病情变化密切相关,对急性阑尾炎发病和病情评估具有一定诊断价值,而联合诊断可提高诊断效能,具有较高的临床意义。

关键词: 白细胞, C 反应蛋白, 急性阑尾炎, 诊断价值

Abstract:

Objective To investigate the diagnostic value of leukocyte count and serum C reactive protein levels in the onset of acute appendicitis and changes in the condition. Method 150 patients with acute appendicitis treated in Guihang Guiyang Hospital from October 2018 to June 2021 were selected as the observation group, including 63 cases of simple appendicitis, 52 cases of suppurative appendicitis and 35 cases of gangrenous appendicitis according to the pathological type. 50 patients with abdominal pain suspected of appendicitis were selected as the control group. The leukocyte count and serum C reactive protein level of the two groups were compared, and the leukocyte count and serum C reactive protein level of patients with acute appendicitis of different pathological types were compared. The diagnostic efficacy of leukocyte count and serum C reactive protein level for acute appendicitis was calculated, and the receiver operating characteristic curve (ROC curve) was drawn. Result The leukocyte count and serum C reactive protein level in the observation group were significantly higher than those in the control group (P < 0.01). The leukocyte count and serum C reactive protein level in patients with gangrenous appendicitis were significantly higher than those in patients with suppurative appendicitis and simple appendicitis. The leukocyte count and serum C reactive protein level in patients with suppurative appendicitis were significantly higher than those in patients with simple appendicitis (P < 0.01). ROC curve analysis showed that the area under ROC curve (0.8952) of leukocyte count > 10×109/L combined with C reactive protein > 50mg/L was the highest in the diagnosis of acute appendicitis, which was significantly higher than that of other diagnostic methods (P< 0.05). Conclusion Leukocyte count and serum C reactive protein levels in patients with acute appendicitis are significantly increased and are closely related to the change of condition, which has certain diagnostic value for the onset and evaluation of acute appendicitis, while combined diagnosis can improve diagnostic efficacy and have high clinical significance.

Key words: Leukocyte count, C reactive protein, Acute appendicitis, Diagnostic value