乌司他丁联合低分子肝素治疗急性胰腺炎临床效果分析

临床普外科电子杂志 ›› 2022, Vol. 10 ›› Issue (1): 77-.

乌司他丁联合低分子肝素治疗急性胰腺炎临床效果分析

1. 北京中西医结合医院急诊科，北京 100038；2. 解放军总医院第四医学中心急诊科，北京 100048

出版日期:2022-01-01 发布日期:2022-03-22

Clinical effect of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis

1. Emergency Department of Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing 100038,China; 2. Emergency Department of the Fourth Medical Center of PLA General Hospital, Beijing 100048,China

Online:2022-01-01 Published:2022-03-22

摘要/Abstract

摘要：

目的探讨乌司他丁联合低分子肝素用于急性胰腺炎治疗的临床效果。方法选取2015 年2 月至2021 年3 月北京中西医结合医院就诊的急性胰腺炎患者160 例，按照随机数字表法分两组，每组各80 例，两组均常规给予胃肠减压、抑制胃酸及胰液分泌、抗炎、补液等治疗，对照组另加用低分子肝素钙，观察组另加用乌司他丁+ 低分子肝素钙。观察比较两组患者的炎症因子[ 白细胞介素（interleukin,IL）-1、IL-10 及肿瘤坏死因子（tumor necrosis factor,TNF)-α] 及肠道黏膜屏障相关指标[ 二胺氧化酶（diamine oxidase,DAO）、D- 乳酸及尿乳果糖/ 甘露醇]，以及疾病转归。结果观察组患者接受治疗7d 后IL-1、TNF-α 水平低于对照组，而IL-10 水平高于对照组（P ＜ 0.05）；观察组患者DAO、D- 乳酸及尿乳果糖/ 甘露醇水平低于对照组（P ＜ 0.05）；观察组患者疾病缓解率高于对照组（P ＜ 0.05）。结论乌司他丁联合低分子肝素治疗急性胰腺炎可有助于减轻机体炎症反应，改善肠黏膜受损情况，有利于疾病的缓解与良性转归。

关键词: 急性胰腺炎, 乌司他丁, 低分子肝素

Abstract:

Objective To investigate the clinical effect of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis. Method 160 patients with acute pancreatitis treated in Beijing Integrated Traditional Chinese and Western Medicine Hospital from February 2015 to March 2021 were randomly divided into two groups, 80 cases in each group. Both groups were routinely treated with gastrointestinal decompression, inhibition of gastric acid and pancreatic juice secretion, antiinflammatory

and rehydration. The control group was additionally treated with low molecular weight heparin calcium, and the observation group was additionally treated with ulinastatin+low molecular weight heparin calcium. The inflammatory factors [interleukin(IL)-1, IL-10, tumor necrosis factor (TNF)-α] and intestinal mucosal barrier related indexes [diamine oxidase (DAO), D-lactic acid and urinary lactulose / mannitol] were observed and compared between the two groups, and the outcome of the disease. Result The levels of IL-1 and TNF -α in the observation group were lower than those in the control group 7 days after treatment. The levels of IL-10 in the observation group were higher than those in the control group (P ＜ 0.05); The levels of Dao, D-lactic acid and urinary lactulose/mannitol in the observation group were lower than those in the control group (P ＜ 0.05); The disease remission rate in the observation group was higher than that in the control group (P ＜ 0.05). Conclusion Ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis can help to reduce the

inflammatory response, improve the damage of intestinal mucosa, and is conducive to the remission and benign prognosis of the disease.

Key words: Acute pancreatitis, Ulinastatin, Low molecular weight heparin

陈峥, 丁俊楠. 乌司他丁联合低分子肝素治疗急性胰腺炎临床效果分析 [J]. 临床普外科电子杂志, 2022, 10(1): 77-.

CHEN Zheng, DING Junnan. Clinical effect of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis [J]. Journal of General Surgery for Clinicians, 2022, 10(1): 77-.