The model of AS desulfurization process is established with Aspen Plus.Simulation is done by adopting Box-Behnken method to test the absorption effect of the AS desulfurization column.The correlation between H2S content at gas outlet and process parameter is analyzed.The process parameters are also optimized.After the optimization，the H2S concentration at the gas outlet can meet the requirement of production，which demonstrates that the model is accurate and the optimization is viable.