临床普外科电子杂志 ›› 2024, Vol. 12 ›› Issue (3): 32-.

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腹腔镜胆囊切除术对胆囊结石合并胆总管结石患者的胃肠道生活质量的影响

  

  1. 吴川市人民医院 普通外科二区,广东 湛江 524500
  • 出版日期:2024-07-01 发布日期:2024-10-17

The impact of laparoscopic cholecystectomy on gastrointestinal quality of life in patients with gallstones and choledocholithiasis

  1. General Surgery Zone 2 of Wuchuan People's Hospital, Guangdong Zhanjiang 524500, China
  • Online:2024-07-01 Published:2024-10-17

摘要:

目的 探讨应用腹腔镜胆囊切除术对胆囊结石合并胆总管结石患者的胃肠道生活质量的影响。方法 选取 2022 年 3 月至 2024 年 3 月于吴川市人民医院接受治疗的胆囊结石合并胆总管结石患者 100 例,根据随机数字表法分为对照组和观察组,各 50 例。对照组采用传统手术方式治疗,观察组采用腹腔镜胆囊切除术治疗,比较两组患者术前、术后 3d 的胃肠道生活质量、炎症指标及肝功能。结果 术前,两组患者的胃肠道生活质量评分无显著差异 [ 对照组(79.25±4.73)分比观察组(80.21±4.77)分,t=1.011,P=0.315]。术后 3d,观察组的胃肠道生活质量得分为(137.86±6.33),显著高于对照组(122.19±6.48),差异有显著性(t=12.233,P < 0.001)。术后 3d,两组患者的 C 反应蛋白、肿瘤坏死因子 -α、白细胞计数水平均较术前升高,但观察组的各项数值均低于对照组,差异有显著性(P < 0.001)。术后 3d,两组患者的 γ- 谷氨酰转移酶、谷丙转氨酶、谷草转氨酶水平均较术前降低,观察组的各项数值均高于对照组,差异有显著性(P < 0.001)。结论 应用腹腔镜胆囊切除术治疗胆囊结石合并胆总管结石患者,可改善患者术后的胃肠道生活质量,减轻患者术后的炎症反应,减轻手术对患者肝功能的影响。

关键词: 腹腔镜胆囊切除术, 胆囊结石, 胆总管结石, 胃肠道生活质量

Abstract:

Objective To explore the impact of laparoscopic cholecystectomy on the gastrointestinal quality of life in patients with gallstones and common bile duct stones. Method 100 patients with gallstones and choledocholithiasis who received treatment at Wuchuan People's Hospital from March 2022 to March 2024 were selected and randomly divided into a control group and an observation group, with 50 cases in each group, using a random number table. The control group was treated with traditional surgical methods, while the observation group was treated with laparoscopic cholecystectomy. The gastrointestinal quality of life, infl ammatory indicators, and liver function of the two groups of patients were compared before and 3 days after surgery. Result Before surgery, there was no signifi cant diff erence in the gastrointestinal quality of life scores between the two groups of patients [the control group (79.25±4.73) points compared to the observation group (80.21±4.77) points, t=1.011,P=0.315]. On postoperative day 3, the gastrointestinal quality of life score of the observation group was (137.86±6.33), signifi cantly higher than that of the control group (122.19±6.48), and the diff erence was signifi cant (t=12.233, P < 0.001). On postoperative day 3, the levels of CRP, TNF-α, and white blood cell count in both groups increased compared to preoperative levels, but the values in the observation group were lower than those in the control group, and the difference was significant (P < 0.001). On postoperative day 3, the levels of γ-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase in both groups decreased compared to preoperative levels, and the values in the observation group were higher than those in the control group, with signifi cant diff erences (P < 0.001). Conclusion The application of laparoscopic cholecystectomy in the treatment of patients with gallstones and common bile duct stones can improve their postoperative gastrointestinal quality of life, reduce their postoperative infl ammatory response, and alleviate the impact of surgery on their liver function.

Key words: Laparoscopic cholecystectomy, Gallstones, Choledocholithiasis, Gastrointestinal quality of life