微小核糖核酸在肝细胞癌中的作用研究进展

临床普外科电子杂志 ›› 2024, Vol. 12 ›› Issue (1): 18-.

微小核糖核酸在肝细胞癌中的作用研究进展

滨州医学院附属医院肝胆外科，山东滨州 256603

出版日期:2024-01-01 发布日期:2024-04-16
基金资助:
山东省省级临床重点肝胆胰肿瘤专科学科建设项目（SLCZDZK-2401）；

2023 年大学生创新创业训练计划省级项目（S202310440033）

Research progress on the role of micro ribonucleic acid in hepatocellular carcinoma

Hepatobiliary Department of Binzhou Medical College Affiliated Hospital， Shandong Binzhou 256603, China

Online:2024-01-01 Published:2024-04-16

摘要/Abstract

摘要：

微小核糖核酸（micro ribonucleic acid，miRNA）是指一类具有约22 个核苷酸的高度保守的内源性非编码RNA。大量研究表明，其在肝细胞癌的发生发展进程中扮演了极为重要的角色，可作为肝细胞癌相关基因表达的调控分子，部分也参与激活细胞信号转导通路来影响肝细胞癌发生发展。本文就miRNA在肝细胞癌中的作用研究进展作一综述，以期能够为寻找肝细胞癌的诊断标志物以及研究分子靶向药物提供思路。

关键词: 核糖核酸, 肝细胞癌, 靶向调控, 生物标志物

Abstract:

Micro ribonucleic acid (miRNA) refer to a highly conserved class of endogenous non-coding RNA, each composed of approximately 22 nucleotides. Numerous studies have demonstrated that miRNAs play a crucial role in the initiation and progression of hepatocellular carcinoma (HCC). MiRNAs function as regulatory molecules in the context of gene expression related to HCC. Some miRNAs also participate in the activation of cellular signaling pathways, and these pathways contribute to the occurrence and development of hepatocellular carcinoma. The review provides an overview of the research progress on the role of miRNAs in hepatocellular carcinoma, aiming to contribute insights into the identification of diagnostic markers for HCC and the exploration of moleculartargeted therapies.

Key words: Ribonucleic acid, Hepatocellular carcinoma, Targeted regulation, Biomarkers

张阳, 范钟辰, 辛凯轩, 张兴元. 微小核糖核酸在肝细胞癌中的作用研究进展 [J]. 临床普外科电子杂志, 2024, 12(1): 18-.

Zhang Yang, Fan Zhongchen, Xin Kaixuan, Zhang Xingyuan. Research progress on the role of micro ribonucleic acid in hepatocellular carcinoma [J]. Journal of General Surgery for Clinicians, 2024, 12(1): 18-.