乳腺浸润性导管/ 小叶混合癌与浸润性小叶癌、导管癌的临床病理特征及预后差异

临床普外科电子杂志 ›› 2021, Vol. 9 ›› Issue (1): 24-.

乳腺浸润性导管/ 小叶混合癌与浸润性小叶癌、导管癌的临床病理特征及预后差异

1. 深圳市龙华区中心医院病理科，广东深圳 518110； 2. 深圳市龙华区中心医院普通外科，广东深圳 518110

出版日期:2021-01-01 发布日期:2021-05-07

Clinicopathological characteristics and prognosis of invasive ductal/lobular mixed carcinoma, invasive lobular carcinoma and invasive ductal carcinoma of breast

1. Pathology department, Shenzhen Longhua District Central Hospital, Shenzhen 518110, Guangdong;
2. General surgery, Shenzhen Longhua District Central Hospital, Shenzhen 518110, Guangdong

Online:2021-01-01 Published:2021-05-07

摘要/Abstract

摘要： 摘要：目的研究乳腺浸润性导管/ 小叶混合癌（infiltrative ductal/lobular mixed carcinoma,IDC-L）与浸润性小叶癌（infiltrative lobular carcinoma,ILC）及浸润性导管癌（infiltrative ductal carcinoma,IDC）病理特征及预后差异。方法选择深圳市龙华区中心医院2011 年9 月至2020 年9 月收入的254 例乳腺癌患者，其中IDC-L 18 例，ILC 20 例，IDC 216 例，观察患者临床病理特征预后情况。结果 IDC-L、ILC 及IDC 患者在年龄、肿瘤大小、多中心病灶、脉管浸润、HER2 状态、Ki-67 表达方面具有明显差异，IDC-L 患者发病年龄较小、肿瘤直径>2.0cm 较多，而IDC 患者多中心病灶及脉管浸润较少，IDC-L 与ILC 患者的HER2 阳性及Ki-67 高表达比例均低于IDC，差异有显著性（P<0.05）。年龄、更年期状态、肿瘤大小、淋巴结状态、多中心病变、淋巴血管侵犯、HER2 状态、Ki-67 表达均是临床病理特征差异的影响因素。无乳腺癌间期(breast cancer-free interval,BCFi)、总生存期（overall survival,OS）与患者肿瘤大小、淋巴结状态、淋巴血管侵犯、Ki-67 表达之间是存在一定关系（P<0.05）。结论在乳腺癌患者中，ILC 与IDC-L 之间
临床病理特征存在一定相似，但三者有明显差异，临床可加以区分，以便对患者更好地进行治疗。

关键词: 关键词：乳腺浸润性导管/ 小叶混合癌, 浸润性小叶癌, 浸润性导管癌, 病理, 预后

Abstract: Abstracts: Objective To study the pathological characteristics of breast infiltrative ductal / lobular mixed carcinoma(IDC-L), infiltrative lobular carcinoma(ILC) and infiltrative ductal carcinoma(IDC). Methods From September 2011 to September 2020,254 breast cancer patients were selected, Among them, there were 18 cases of IDC-L, 20 cases of ILC and 216 cases of IDC. The prognosis of the three groups of patients was observed. Results IDC- L, ILC and IDC patients had significant differences in age, tumor size, multicentric lesions, vascular invasion, HER2 status, Ki-67 expression. IDC-L patients had younger onset age, more tumor diameter>2.0 cm, while IDC patients had less multicentric lesions and vascular invasion, while HER2 positive rate and Ki-67 high expression ratio in IDC-L and ILC patients were lower than IDC, the difference was statistically significant(P<0.05). Age, climacteric state, tumor size, lymph node state, multicentric lesions, lymphatic vessel invasion, HER2 state and Ki-67 expression were all the influencing factors of clinic pathological differences. Breast cancer-free interval and overall survival were related to tumor size, lymph node status, lymphatic vessel invasion and Ki-67 expression (P<0.05). Conclusion In breast cancer patients, the clinicopathological characteristics of ILC and IDC-L are similar to each other, but there are obvious differences among ILC, IDC-L and IDC. The breast cancer patients can be differentiated clinically and treated better.

Key words: Key words: Invasive ductal/lobular mixed carcinoma of breast, Invasive lobular carcinoma, Invasive ductal carcinoma, Pathology, Prognosis

冷敏芳, 程文德, 肖小琴, 刘峰. 乳腺浸润性导管/ 小叶混合癌与浸润性小叶癌、导管癌的临床病理特征及预后差异[J]. 临床普外科电子杂志, 2021, 9(1): 24-.

LENG Minfang, CHENG Wende, XIAO Xiaoqin, LIU Feng. Clinicopathological characteristics and prognosis of invasive ductal/lobular mixed carcinoma, invasive lobular carcinoma and invasive ductal carcinoma of breast[J]. Journal of General Surgery for Clinicians, 2021, 9(1): 24-.