多种血清肿瘤标志物联合检测在原发性肝癌诊断中的应用研究

临床普外科电子杂志 ›› 2022, Vol. 10 ›› Issue (4): 23-.

多种血清肿瘤标志物联合检测在原发性肝癌诊断中的应用研究

梧州市工人医院普外科一区，广西梧州 543000

出版日期:2022-10-01 发布日期:2023-01-13
基金资助:
梧州市科技计划项目（201902076）

Application of multiple serum tumor markers in the diagnosis of primary liver cancer

General Surgery Division Ⅰ of Wuzhou Workers' Hospital, Guangxi Wuzhou 543000, China

Online:2022-10-01 Published:2023-01-13

摘要/Abstract

摘要：

目的探究多种血清肿瘤标志物联合检测在原发性肝癌诊断中的应用效果。方法选取2019年1 月至2021 年12 月在梧州市工人医院接受治疗的原发性肝癌、良性肝脏疾病及非肝脏疾病患者105 例，根据疾病不同分别纳入肝癌组、良性肝病组、对照组各35 例。检测三组患者血清中异常凝血酶原（Desg-carboxyl prothrombin，DCP）、甲胎蛋白（alpha-fetoprotein，AFP）、α-L- 岩藻糖苷酶(α-L-fucosidase，AFU）、糖类抗原19-9（carbohydrate antigen 19-9，CA19-9）的水平，评价以上指标单独与联合诊断价值。

结果肝癌组患者的DCP、AFP、AFU、CA19-9 水平均高于其他两组，且组间对比存在显著差异（P ＜ 0.05）。经受试者操作特征曲线分析，血清DCP、AFP、AFU、CA19-9 的最佳诊断界值分别为39.38mAU/ml、48.35μg/L、25.93U/L、50.54U/ml，AFP+AFU 与DCP+AFP+AFU 的串联试验的约登指数最大，为0.757。结论血清DCP、AFP、AFU、CA19-9 单独检测与不同联合检测方式中，AFP 联合AFU 诊断原发性肝癌的效能最高。

关键词: 原发性肝癌, 甲胎蛋白, α-L- 岩藻糖苷酶, 联合检测

Abstract:

Objective To explore the application of multiple serum tumor markers in the diagnosis of primary liver cancer. Method 105 patients with primary liver cancer, benign liver disease and non liver disease who were treated in Wuzhou Workers' Hospital from January 2019 to December 2021 were selected, and 35 patients were included in the liver cancer group, the benign liver disease group and the control group respectively according to different diseases. Detect the abnormal prothrombin (DCP), alpha fetoprotein (AFP) α- L-fucosylase(AFU), carbohydrate antigen 19-9 (CA19-9), and evaluate the diagnostic value of the above indicators alone and in

combination. Result The DCP, AFP, AFU, CA19-9 water of patients with liver cancer were higher than those of the other two groups on average, and there was significant difference between the two groups (P<0.05). According to the analysis of the working characteristic curve of the subjects, the best diagnostic thresholds of serum DCP, AFP, AFU and CA19-9 were 39.38mAU/ml, 48.35μg/L, 25.93U/L and 50.54U/ml, respectively. The Jordan index of the tandem test of AFP+AFU and DCP+AFP+AFU was the largest, 0.757. Conclusion Among serum DCP, AFP, AFU and CA19-9, AFP combined with AFU has the highest diagnostic efficacy.

Key words: Primary liver cancer, Alpha-fetoprotein, α-L-fucosidase, Joint testing

蒙建源, 黄海, 朱刚健. 多种血清肿瘤标志物联合检测在原发性肝癌诊断中的应用研究 [J]. 临床普外科电子杂志, 2022, 10(4): 23-.

MENG Jianyuan, HUANG Hai, ZHU Gangjian. Application of multiple serum tumor markers in the diagnosis of primary liver cancer [J]. Journal of General Surgery for Clinicians, 2022, 10(4): 23-.