临床普外科电子杂志 ›› 2022, Vol. 10 ›› Issue (3): 154-.

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右美托咪定对全身麻醉下行腹腔镜胆囊切除术治疗胆囊疾病的老年患者的应激反应的影响

  

  1. 南京医科大学附属江宁医院 麻醉科,江苏 南京 211000
  • 出版日期:2022-07-01 发布日期:2022-10-25

Effect of dexmedetomidine on stress response in elderly patients undergoing laparoscopic cholecystectomy under general anesthesia

  1. Anesthesiology Department of Jiangning Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 211000, China
  • Online:2022-07-01 Published:2022-10-25

摘要:

目的 探讨右美托咪定对全身麻醉下行腹腔镜胆囊切除术老年患者的应激反应的影响。方法 回顾性分析2021 年1 月至2022 年2 月南京医科大学附属江宁医院收治的全身麻醉下行腹腔镜胆囊切除术的老年患者70 例的临床资料,根据麻醉干预方式不同分为对照组和研究组各35 例,对照组患者采用丙泊酚干预,研究组患者采用盐酸右美托咪定注射液干预。比较两组患者麻醉诱导前(T0)、气管插管时(T1)、建立气腹时(T2)、气管导管拔管时(T3)、拔管5min 后(T4)血流动力学指标、应激指标以及手术情况。结果 研究组T0 ~ T3 时心率、平均动脉压均低于对照组(P < 0.05),且两组T4 时血流动力学指标无显著差异(P > 0.05)。研究组T0 ~ T3 时血浆皮质醇水平均低于对照组(P < 0.05),研究组T4 时,血管紧张素Ⅱ水平低于对照组(P < 0.05),且两组T4 时血浆皮质醇水平以及T0 ~ T3 时血管紧张素Ⅱ水平无显著差异(P > 0.05)。研究组患者疼痛持续时间、下床活动时间、腹腔引流管拔除时间、住院时间均短于对照组(P < 0.05)。结论 右美托咪定应用于全身麻醉下行腹腔镜胆囊切除术的老年患者,可改善患者血流动力学指标以及应激指标,缩短疼痛持续、下床及住院等时间,有利于患者术后恢复。

关键词: 右美托咪定, 老年患者, 腹腔镜胆囊切除术, 应激反应, 血流动力学

Abstract:

Objective To investigate the effect of dexmedetomidine on stress response in elderly patients undergoing laparoscopic cholecystectomy under general anesthesia. Method The clinical data of 70 elderly patients with laparoscopic cholecystectomy under general anesthesia treated in Jiangning Hospital Affiliated to Nanjing Medical University from January 2021 to February 2022 were retrospectively analyzed. According to different anesthesia intervention methods, they were divided into control group and study group, with 35 cases in each group. The patients in the control group were treated with propofol, and the patients in the study group were treated with dexmedetomidine hydrochloride injection. The hemodynamic indexes, stress indexes and operation conditions of the two groups were compared before anesthesia induction (T0), during tracheal intubation (T1), during pneumoperitoneum establishment (T2), during tracheal extubation (T3) and 5min after extubation (T4). Result The heart rate and mean arterial pressure of the study group at T0 ~ T3 were lower than those of the control group (P < 0.05), and there was no significant difference between the two groups at T4 (P > 0.05). The level of plasma cortisol in the study group at T0 ~ T3 was lower than that in the control group (P < 0.05), and the level of angiotensin Ⅱ in the study group at T4 was lower than that in the control group (P < 0.05), and there was no significant difference between the two groups at T4 and at T0 ~ T3 (P > 0.05). The duration of pain, time of getting out of bed, time of abdominal drainage tube removal and hospital s tay in the study group were shorter than those in the control group (P < 0.05). Conclusion Dexmedetomidine used in elderly patients undergoing laparoscopic cholecystectomy under general anesthesia can improve hemodynamic and stress indicators, shorten the duration of pain, out of bed and hospitalization, and is conducive to postoperative recovery.

Key words: Dexmedetomidine, Elderly patients, Laparoscopic cholecystectomy, Stress response, Hemodynamics