临床普外科电子杂志 ›› 2025, Vol. 13 ›› Issue (3): 71-.

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贞芪扶正颗粒联合益生菌对早期胃癌术后营养支持患者肠黏膜屏障功能的影响

  

  1. 1. 南京医科大学附属淮安第一医院 肿瘤内科,江苏 淮安 223300;2. 扬州大学附属淮安医院 胃肠外科,江苏 淮安 223300
  • 出版日期:2025-07-01 发布日期:2025-11-20

Effect of zhenqi fuzheng granules combined with probiotics on intestinal mucosal barrier function in patients with early gastric cancer after nutritional support

  1. 1. Oncology Department of Huai’an First Hospital Affiliated to Nanjing Medical University, Jiangsu Huai’an 223300, China;  2. Gastrointestinal Surgery Department of Huai’an Hospital Affiliated to Yangzhou University, Jiangsu Huai’an 223300, China
  • Online:2025-07-01 Published:2025-11-20

摘要:

目的 探讨贞芪扶正颗粒联合益生菌对早期胃癌术后营养支持患者肠黏膜屏障功能的影响。方法 选取 2021 年 8 月至 2023 年 8 月南京医科大学附属淮安第一医院收治的 100 例早期胃癌患者,根据随机抽签方式分为观察组和对照组,各 50 例。对照组采取术后早期肠内营养联合益生菌治疗,观察组则基于此加用贞芪扶正颗粒,比较两组患者术后恢复指标,干预前后患者营养状态、肠黏膜屏障功能变化。结果 观察组患者的肠鸣音恢复时间、首次排气时间、住院时间均短于对照组,差异有显著性(P < 0.01),但两组患者导管留置时间及首次下床活动时间比较无显著差异(P > 0.05)。干预前,两组患者的营养指标水平、肠黏膜屏障功能相关指标水平比较无显著差异(P > 0.05)。干预后,两组患者的营养指标水平均较干预前改善,且观察组患者的转铁蛋白、白蛋白、前白蛋白水平均高于对照组;两组肠黏膜屏障功能相关指标水平较干预前改善,且观察组肠型脂肪酸结合蛋白、降钙素原、D- 乳酸水平均低于对照组,差异均有显著性(P < 0.001)。结论 贞芪扶正颗粒联合益生菌对早期胃癌术后患者营养、肠黏膜屏障功能具有积极意义。

关键词: 贞芪扶正颗粒, 益生菌, 肠内营养, 早期胃癌, 肠黏膜

Abstract:

Objective To explore the impact of zhenqi fuzheng granules combined with probiotics on intestinal mucosal barrier function in patients undergoing nutritional support following early gastric cancer surgery. Method From August 2021 to August 2023, 100 patients with early gastric cancer in Huai'an First Hospital Affiliated to Nanjing Medical University were selected and randomly divided into two groups, 50 cases in each group. The control group was treated with early postoperative enteral nutrition combined with probiotics, while the observation group was treated with zhenqi fuzheng granules based on this. The postoperative recovery indexes of the two groups were compared, and the changes of nutritional status and intestinal mucosal barrier function before and after intervention were compared. Result The recovery time of bowel sounds, the first exhaust time and the hospitalization time of the observation group were shorter than those of the control group, the difference was significant (P < 0.01), but there was no significant difference in the indwelling time of catheter and the first ambulation time between the two groups (P > 0.05). Before intervention, there was no significant difference in the levels of nutritional indicators and intestinal mucosal barrier function related indicators between the two groups (P > 0.05). After the intervention, the nutritional index levels of the two groups were improved, and the levels of transferrin, albumin and prealbumin in the observation group were higher than those in the control group; The levels of intestinal mucosal barrier function related indicators in the two groups were improved, and the levels of intestinal fatty acid binding protein, procalcitonin and D-lactic acid in the observation group were lower than those in the control group, with significant differences (P < 0.001). Conclusion Zhenqi fuzheng granules combined with  probiotics has positive significance on nutrition and intestinal mucosal barrier function in patients with early gastric cancer after operation.

Key words: Zhenqi fuzheng granules, Probiotics, Enteral nutrition, Early gastric cancer, Intestinal mucosa