临床普外科电子杂志 ›› 2025, Vol. 13 ›› Issue (3): 18-.

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红细胞分布宽度与神经元特异性烯醇化酶在结肠癌中的诊断价值

  

  1. 1. 新疆医科大学第五附属医院 肝胆胰腺外科,新疆 乌鲁木齐 830000;2. 新疆生产建设兵团医院 消化内科,新疆 乌鲁木齐 830000
  • 出版日期:2025-07-01 发布日期:2025-11-17

Diagnostic value of erythrocyte distribution width and neuronal enolase in colon cancer

  1. 1. Hepatobiliary Pancreatic Surgery Department of The Fifth Affi liated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China; 2. Gastroenterology Department of Xinjiang Production and Construction Corps Hospital, Xinjiang Urumqi 830000, China
  • Online:2025-07-01 Published:2025-11-17

摘要:

目的 探讨红细胞分布宽度 (red blood cell distribution width,RDW) 与血清神经元特异性烯醇化酶(neuron specifi c enolase,NSE)在结肠恶性肿瘤中的诊断价值。方法 选取新疆医科大学第五附属医院2018 年 1 月至 2021 年 1 月临床明确诊断为结肠癌患者 154 例(结肠癌组)和健康者 150 例 ( 对照组 ),比较两组患者的血常规指标,包括红细胞计数、血小板计数、淋巴细胞比值、RDW,以及肿瘤标志物,包括癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原 125(carbohydrate antigen 125,CA125)、糖类抗原19-9(carbohydrate antigen 125,CA19-9)、NSE 水平,并比较结肠癌患者的 RDW、NSE 水平。通过应用受试者操作特征(receiver operating characteristic,ROC) 曲线分析 RDW、NSE、CEA、CA19-9 对结肠癌的诊断价值。结果 血常规中红细胞计数、淋巴细胞比值、RDW,肿瘤标志物中 NSE、CEA、CA125、CA19-9与对照组比较差异有显著性,血清 RDW 阳性表达与肿瘤病理分期和是否发生淋巴结转移有显著相关性,通过 ROC 曲线得出 RDW、NSE 及其联合 CEA、CA19-9 对结肠癌具有较高诊断价值。结论 RDW、NSE水平升高与结肠癌发生发展可能存在密切关系,两者可能成为结肠癌早期诊断及病情判断的一个重要指标。

关键词: 结肠癌, 红细胞分布宽度, 血清神经元特异性烯醇化酶, 肿瘤标志物, 早期诊断

Abstract:

Objective To explore the diagnostic value of red blood cell distribution width (RDW) and serum neuron specific enolase (NSE) in colon malignant tumors. Method 154 cases of patients with a clear clinical diagnosis of colon cancer (colon cancer group) and 150 cases of healthy people (control group) were selected from The Fifth Affiliated Hospital of Xinjiang Medical University from 2018 January to 2021 January, and the blood routine indexes of the two groups were compared, including red blood cell (RBC), platelet (PLT), lymphocyte ratio (LY%), RDW and tumor We compared the levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA-125), carbohydrate antigen 125 (CA-199), and NSE in colon cancer patients with diff erent clinical data. RDW and NSE levels in colon cancer patients with diff erent clinical data. The diagnostic value of RDW, NSE, CEA and CA19-9 for colon cancer was analyzed by applying receiver operating characteristic (ROC) curve. Result RBC, LY%, RDW in blood routine, NSE, CEA, CA125, CA19-9 in tumor markers were statistically significant compared with the control group, and there was a significant correlation between the positive expression of serum RDW and the pathological stage of the tumor and whether lymph node metastasis had occurred, and it was concluded that RDW, NSE and its combination with CEA and CA19-9 had high diagnostic value in colon cancer by ROC curve. The ROC curve showed that RDW, NSE and their combination with CEA and CA19-9 had high diagnostic value for colon cancer. Conclusion Elevated levels of RDW and NSE may have a close relationship with the development of colon cancer, and both of them may become an important indicator for the early diagnosis and judgment of colon cancer.

Key words: Colon cancer, Red blood cell distribution width, Serum neuron-specific enolase, Tumor markers, Early diagnosis