关键词: 腹腔镜结直肠癌根治术, 个体化膳食营养干预, 免疫功能

Abstract:

Objective To investigate the effect of individualized dietary nutrition intervention on the immune function of patients after laparoscopic radical resection of colorectal cancer. Method: Sixty patients with colorectal cancer admitted to Rudong Hospital Affiliated to Nantong University Xinglin College from January 2023 to June 2024 were selected as the research subjects. Divided into an observation group and a control group using envelope method, with 30 cases in each group. The control group received routine nutritional intervention, while the observation group received personalized dietary nutrition intervention on the basis of the control group. The immune function, inflammatory factors, and levels of adverse events were compared between the two groups. Result Before surgery, there was no significant difference in immune function indicators between the two groups of patients (P ＞ 0.05). On postoperative day 7, the levels of CD3⁺and CD4⁺T cells in both groups increased compared to preoperative levels, and the levels of CD3⁺and CD4⁺T cells in the observation group were higher than those in the control group, with significant differences (P ＜ 0.05). On postoperative day 7, the levels of CD8⁺T cells in both groups decreased compared to preoperative levels (P ＜ 0.05); And the observation group was lower than the control group, but there was no significant difference between the groups (P ＞ 0.05). Before surgery, there was no significant difference in the levels of inflammatory factors between the two groups of patients (P ＞ 0.05). On postoperative day 7, the levels of interleukin-6, tumor necrosis factor-α, and C reactive protein in both groups of patients increased compared to preoperative levels, and the observation group was lower than the control group, with significant differences (P ＜ 0.05). The incidence of adverse events in the observation group was lower than that in the control group (6.67% vs. 26.67%), and the difference was significant (χ2=4.320, P=0.038). Conclusion Individualized dietary and nutritional intervention for laparoscopic radical resection of colorectal cancer patients can effectively improve their immune function, reduce inflammatory reactions, and improve prognosis.

Key words: Laparoscopic radical resection for colorectal cancer, Individualized dietary nutrition intervention, Immune function