关键词: 急性胃穿孔, 腹腔镜修补术, 开腹修补术, 炎症反应, 胃肠激素, 并发症

Abstract:

Objective To compare the therapeutic eff ects of laparoscopic repair and open repair for acute gas-tric perforation. Method 100 patients with acute gastric perforation admitted to Yunxi County People’s Hospital in Shiyan City from January 2021 to December 2023 were selected and randomly divided into two groups of 50 each using a random number table method. The control group underwent open abdominal repair surgery, while the obser-vation group underwent laparoscopic repair surgery. The clinical eff ects of the two groups were compared. Result The incision length of the observation group patients was shorter than that of the control group, the intraoperative blood loss was less than that of the control group, and the operation time, bed getting time, bowel sound recovery time, exhaust time, and hospitalization time were all shorter than those of the control group, with signifi cant dif-ferences (P ＜ 0.001). Before surgery, there was no signifi cant diff erence in the levels of gastrointestinal hormones and infl ammatory factors between the two groups of patients (P ＞ 0.05); After surgery, the levels of vasoactive intestinal peptide, gastrin, and motilin in the observation group were higher than those in the control group, while the levels of interleukin-6, tumor necrosis factor - α, and C-reactive protein were lower than those in the control group, with signifi cant diff erences (P ＜ 0.001). The total incidence of complications in the observation group was 2.00% (1/50), and the recurrence rate was 0, both lower than those in the control group [20.00% (10/50), 44.00% (6/50), respectively], with signifi cant diff erences (P ＜ 0.05). Conclusion Laparoscopic repair and open repair can both improve the condition of patients with acute gastric perforation to a certain extent. However, laparoscopic re-pair can reduce the trauma to the patient’s body, help alleviate the body’s infl ammatory response and lower the incidence of postoperative complications and recurrence.

Key words: Acute gastric perforation, Laparoscopic repair surgery, Open abdominal repair surgery, Infl ammatory response, Gastrointestinal hormones, Complication