临床普外科电子杂志 ›› 2025, Vol. 13 ›› Issue (4): 34-.

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腹腔镜下钬激光碎石术治疗胆管结石的临床效果及对创伤应激指标的影响

  

  1. 郴州市第四人民医院 肝胆外科,湖南 郴州 423000
  • 出版日期:2025-10-01 发布日期:2026-01-29
  • 基金资助:

    湘南学院 2023 年度校级科研项目医院联合项目(2023XJ146)

Clinical effect of laparoscopic holmium laser lithotripsy for the treatment of bile duct stones and its impact on trauma stress indicators

  1. Hepatobiliary Surgery Department of Fourth People’s Hospital of Chenzhou City, Hunan Chenzhou 423000, China
  • Online:2025-10-01 Published:2026-01-29

摘要:

目的 探讨腹腔镜下钬激光碎石术治疗胆管结石的临床效果及对创伤应激指标的影响。方法 选取 2023 年 10 月至 2024 年 9 月郴州市第四人民医院收治的 120 例胆管结石患者为研究对象,按照随机数字表法分为试验组和参照组,每组 60 例。参照组采用常规腹腔镜胆总管切开取石术治疗,试验组采用腹腔镜下钬激光碎石术治疗。比较两组取石成功率、手术相关指标及手术前后创伤应激指标,观察两组患者并发症。结果 试验组取石成功率 96.67%(58/60)高于参照组 83.33%(50/60),差异有显著性(P=0.015)。试验组的手术时间、首次排气时间和住院时间均短于参照组,术中出血量少于对照组,差异均有显著性(P< 0.001)。术前,两组患者的皮质醇、肾上腺素水平比较无显著差异(P > 0.05)。术后 1d,两组患者的皮质醇、肾上腺素水平较术前均有所升高,且试验组低于参照组,差异均有显著性(P < 0.001)。试验组并发症发生率为 1.67%(1/60),低于参照组 16.67%(10/60),差异有显著性(P=0.004)。结论 腹腔镜下钬激光碎石术可提高胆管结石取石成功率,降低创伤应激反应,减少并发症发生。

关键词: 腹腔镜, 钬激光碎石术, 胆管结石, 创伤应激, 肝功能

Abstract:

Objective To investigate the clinical efficacy of laparoscopic holmium laser lithotripsy in the treatment of bile duct stones and its impact on trauma stress indicators. Method 120 patients with bile duct stones admitted to the Fourth People’s Hospital of Chenzhou City from October 2023 to September 2024 were selected as the research subjects. They were randomly divided into an experimental group and a reference group using a random number table method, with 60 patients in each group. The reference group was treated with conventional laparoscopic choledochotomy for stone removal, while the experimental group was treated with laparoscopic holmium laser lithotripsy. Compare the success rate of stone extraction, surgical related indicators, and pre - and post-operative trauma stress indicators between two groups, and observe the complications of the two groups of patients. Result The success rate of stone removal in the experimental group was 96.67% (58/60), which was significantly higher than 83.33% (50/60) in the control group (P=0.015). The operation time, first exhaust time and hospitalization time of the experimental group were shorter than those of the control group, and the intraoperative blood loss of the experimental group was less than that of the control group, with significant differences (P < 0.001). There was no significant difference in the levels of cortisol and epinephrine between the two groups before operation (P > 0.05). One day after operation, the levels of cortisol and epinephrine in the two groups were higher than those before operation, and the levels in the experimental group were lower than those in the control group, with significant differences (P < 0.001). The incidence of complications in the experimental group was 1.67% (1/60), which was significantly lower than 16.67% (10/60) in the control group (P=0.004). Conclusion Laparoscopic holmium laser lithotripsy can improve the success rate of removing bile duct stones, reduce traumatic stress reactions, and minimize complications.

Key words: Laparoscope, Holmium laser lithotripsy, Bile duct stones, Traumatic stress, Liver function